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Reportlinker Adds Proteomics - Technologies, Markets and Companies
Date:11/9/2010

y . 193

Neurotoxicity .. 194

Protein/peptide therapeutics . 194

Peptide-based drugs . 194

Phylomer® peptides .. 195

Cryptein-based therapeutics .. 195

Synthetic proteins and peptides as pharmaceuticals .. 196

Genetic immunization and proteomics .. 196

Proteomics and gene therapy 197

Role of proteomics in clinical drug development .. 197

Pharmacoproteomics 197

Role of proteomics in clinical drug safety 198

7. Application of Proteomics in Human Healthcare 200

Introduction .. 200

Clinical proteomics . 201

Definition and standards . 201

Vermillion's Clinical Proteomics Program 201

Pathophysiology of human diseases .. 202

Diseases due to misfolding of proteins 202

Mechanism of protein folding .. 203

Nanoproteomics for study of misfolded proteins 204

Therapies for protein misfolding . 204

Intermediate filament proteins . 205

Significance of mitochondrial proteome in human disease 206

Proteome of Saccharomyces cerevisiae mitochondria .. 206

Rat mitochondrial proteome 206

Proteomic approaches to biomarker identification .. 207

The ideal biomarker . 207

Proteomic technologies for biomarker discovery .. 207

MALDI mass spectrometry for biomarker discovery . 208

BAMF Technology 208

Protein biochips/microarrays and biomarkers .. 209

Antibody-based biomarker discovery .. 209

Tumor-specific serum peptidome patterns . 209

Search for protein biomarkers in body fluids . 210

Challenges and strategies for discovery of protein biomarkers in plasma .. 210

3-D structure of CD38 as a biomarker . 211

BD™ Free Flow Electrophoresis System .. 211

Isotope tags for relative and absolute quantification 212

N-terminal peptide isolation from human plasma . 212 - 9 -

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