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Reportlinker Adds Proteomics - Technologies, Markets and Companies

interaction map of Drosophila melanogaster .. 177

Protein-interaction map of Wellcome Trust Sanger Institute 177

Protein-protein interactions as targets for therapeutic intervention 177

Inhibition of protein-protein interactions by peptide aptamers 178

Selective disruption of proteins by small molecules 178

Post-genomic combinatorial biology approach . 178 - 8 -

Differential proteomics . 179

Shotgun proteomics 179

Chemogenomics/chemoproteomics for drug discovery 180

Chemoproteomics-based drug discovery . 181

Companies involved in chemogenomics/chemoproteomics 182

Activity-based proteomics 183

Locus Discovery technology . 183

Automated ligand identification system 184

Expression proteomics: protein level quantification .. 184

Role of phage antibody libraries in target discovery .. 185

Analysis of posttranslational modification of proteins by MS . 185

Phosphoproteomics for drug discovery . 186

Application of glycoproteomics for drug discovery . 186

Role of carbohydrates in proteomics 186

Challenges of glycoproteomics .. 187

Companies involved in glycoproteomics . 187

Role of protein microarrays/ biochips for drug discovery 188

Protein microarrays vs DNA microarrays for high-throughput screening .. 188

BIA-MS biochip for protein-protein interactions 188

ProteinChip with Surface Enhanced Neat Desorption .. 189

Protein-domains microarrays . 189

Some limitations of protein biochips 189

Concluding remarks about role of proteomics in drug discovery .. 190

RNA versus protein profiling as guide to drug development .. 190

RNA as drug target .. 190

Combination of RNA and protein profiling .. 191

RNA binding proteins . 192

Toxicoproteomics. 192

Hepatotoxicity 192

Nephrotoxicity 193


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