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Bioinformatic analysis of proteomics data for drug discovery 163
Drug design based on structural proteomics .. 163
Protein crystallography for determining 3D structure of proteins 163
Automated 3D protein modeling .. 164
Drug targeting of flexible dynamic proteins 164
Companies involved in structure-based drug-design .. 164
Integration of genomics and proteomics for drug discovery .. 165
Ligand-receptor binding .. 166
Role of proteomics in study of ligand-receptor binding .. 166
Aptamer protein binding . 167
Systematic Evolution of Ligands by Exponential Enrichment . 167
Aptamers and high-throughput screening 167
Nucleic Acid Biotools.. 168
Aptamer beacons 168
Peptide aptamers 169
Riboreporters for drug discovery . 169
Target identification and validation 169
Application of mass spectrometry for target identification 170
Gene knockout and gene suppression for validating protein targets .. 170
Laser-mediated protein knockout for target validation .. 170
Integrated proteomics for drug discovery .. 171
High-throughput proteomics .. 171
Companies involved in high-throughput proteomics 172
Drug discovery through protein-protein interaction studies .. 172
Protein-protein interaction as basis for drug target identification 173
Protein-PCNA interaction as basis for drug design .. 173
Two-hybrid protein interaction technology for target identification 174
Biosensors for detection of small molecule-protein interactions .. 174
Protein-protein interaction maps .. 175
ProNet (Myriad Genetics) . 175
Hybrigenics' maps of protein-protein interactions . 175
CellZome's functional map of protein-protein interactions . 176
Mapping of protein-protein interactions by mass spectrometry 176
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