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Reportlinker Adds Ophthalmology DrugFutures
Date:4/21/2011

and the first generics have been approved.

Others in this segment are also set to lose exclusivity over the next few years. Dependent on the outcome of patent litigation, Alcon's Travatan Z (travoprost) could face generic competition in the US as early as December 2011. Allergan's US patents for Lumigan (bimatoprost) will expire in 2012 and 2014, while the European patents are set to expire in various markets between 2013 and 2017.

In the short term, there may be new competition in the US if Merck & Co is successful in gaining approval for Saflutan (tafluprost). Merck & Co has a licensing agreement for the product with Santen Pharmaceutical who market it in some Asian/European markets. Beyond new formulations and combination products in Phase III, the most advanced novel agents have yet to progress beyond Phase II.

The report covers

Market analysis

What is glaucoma?

How is it treated?

Why are new treatments needed?

What is in development?

Glaucoma prevalence

Launched products

Alphagan (brimonidine)

Trusopt (dorzolamide)

Azopt (brinzolamide)

Xalatan (latanoprost)

Lumigan (bimatoprost)

Travatan (travoprost)

Saflutan (tafluprost)

Phase II

BOL-303259-X

AR-12286

Phase I/II

INO-8875

DRY EYE SYNDROME

Alongside glaucoma and AMD, dry eye is a growing problem and one that also increases with age. While this condition is widely treated with artificial tear products that are available over the counter, the prescription market is currently worth around US$1.5 billion.

There are relatively few prescription pharmaceuticals to treat more severe cases; in the US, Allergan's Restasis (ciclosporin) ophthalmic emulsion is currently the only product approved to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation. Compet
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SOURCE S ....... 118
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