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Reportlinker Adds Ophthalmology DrugFutures
Date:4/21/2011

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The current standard of care for wet AMD is Lucentis (ranibizumab), marketed by Roche in the US and Novartis elsewhere. Growth has been impressive since its launch in 2006; global sales amounted to US$3 billion in 2010. The cost of treatment is high, however, and there is some competition from off-label use of Roche's Avastin (bevacizumab), which is significantly cheaper. In the US, the National Eye Institute is conducting a major Phase III comparative study of Avastin and Lucentis for the treatment of AMD.

But there is new competition expected on the market. The most advanced developmental treatment for AMD is Bayer and Regeneron's VEGF Trap-Eye. Following positive top-line results from Phase III trials, regulatory filings have been planned in the US and EU in 2011. If approved, it is expected that this product will be quickly taken up in the market-place. It appears to have similar efficacy to Lucentis with less frequent dosing, which is likely to prove popular among patients and healthcare providers alike.

The report covers

Market analysis

What is macular degeneration?

How is it treated?

Photodynamic Therapy

Anti-VEGF

Why are new treatments needed?

What is in development?

AMD prevalence

Launched products

Lucentis (ranibizumab)

Macugen (pegaptanib)

Visudyne (verteporfin)

Phase III

VEGF Trap-Eye

Phase II

ACU-4429

PF-4523655

GLAUCOMA

Glaucoma affects around 65-70 million people worldwide and is the second leading cause of blindness, after cataracts. The WHO estimates that glaucoma was responsible for around 12.3% of world blindness in 2002, affecting around five million people.

Undoubtedly, generic companies will claim a significant share of the US$4.9 billion glaucoma market over the next few years. Pfizer's US patent for the market leader, Xalatan (latanoprost) expired in March 2011
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