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Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development
Date:10/26/2009

tly the greatest barrier to successful development of ion channel modulators?

Question 12. Do you think that the low conductance of many types of ion channels has been a major barrier to both their study and the

identification of selective modulators?

Question 13. How has your organization's level of activity changed in the past five years in terms of developing ion channel modulators?

Question 14. Does your organization plan to change its level of involvement with ion channels over the next three years?

Question 15. Do you have any additional observations about the discovery and development of ion channel modulators?

REFERENCES 133

COMPANY INDEX WITH WEB ADDRESSES 149

Tables

Table 2.1. Families of Ion Channels

Table 2.2. Voltage-Gated Calcium Channels

Table 2.3. Old and New Nomenclatures of Glutamate-Gated Ion Channels

Table 4.1. L-Type Calcium Channel Blockers and 2007 Sales

Table 4.2. KATP Channel Modulators and 2007 Sales

Table 4.3. GABAA Channel Modulators and 2007 Sales

Table 4.4. Class I Antiarrhythmic Agents (Sodium Channel Blockers)

Table 4.5. Class III Antiarrhythmic Agents (Potassium Channel Blockers)

Table 4.6. Anticonvulsant Agents and 2007 Sales

Table 4.7. 5-HT3 Antagonists and 2007 Sales

Table 5.1. Ion Channel Modulators Awaiting Regulatory Approval

Table 5.2. Ion Channel Modulators in Phase III Studies

Table 5.3. Ion Channel Modulators in Phase II Studies for CNS Disorders

Table 5.4. Ion Channel Modulators for Non-CNS Conditions in Phase II Studies

Table 5.5. Ion Channel Modulators in Phase I Studies

Figures

Figure 5.1. Ion Channels Modulators in Development by Major Pharmaceutical Companies

Figure 5.2. Ion Channel Modulators in Development by Target
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