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Reportlinker Adds Ion Channel Modulator Pipelines: Targets and Agents in Development
Date:10/26/2009

gand-Gated

Voltage-Gated

Conformational States

Accessory Proteins and Subunits

Specificity and Function

1.3. Opportunity

CHAPTER 2 - TARGET CLASSES

2.1. Overview

2.2. Classification

2.3. Voltage-Gated Channels

Chloride

ClC Channels

Calcium

Potassium

KV Channels

KCa Channels

Kir Channels

K2P Channels

Degenerins

Non-Specific Cation Channels

2.4. Ligand-Gated Channels

Cyclic Nucleotide (CNGA, CNGB, and HCN)

Nicotinic Receptors

Glutamate

Kainate

Glycine

5-HT3 Receptors

Purinergic

Transient Receptor Potential Channels

TRPA

CHAPTER 3 - TECHNICAL CONSIDERATIONS

3.1. Introduction

3.2. Target Distribution

3.3. Ion Channel Structures

Structural Biology

3.4. What to Target

Multiple States

Accessory Proteins

The hERG Channel

3.5. Screening Issues

3.6. Non-Electrical Methods

FLIPR Assays

Isotopic Flux

3.7. High-Throughput Electrophysiology

CHAPTER 4 - COMMERCIALLY SUCCESSFUL ION CHANNEL MODULATORS

4.1. Overview

4.2. L-Type Calcium Channel Blockers

4.3. Antidiabetic KATP Modulators

4.5. GABA Analogs

4.6. Antiarrhythmic Agents (Potassium Channel Blockers)

4.7. Anticonvulsants (Sodium Channel Blockers)

4.8. 5-HT3 Antagonists

4.9. Nicotinic Receptors

4.10. Other Ion Channel Modulators

CHAPTER 5 - ION CHANNEL MODULATORS IN CLINICAL DEVELOPMENT

5.1. Overview

By Company


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