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Reportlinker Adds Global Anti-CD20 Monoclonal Antibodies Industry

ntibodies II-2

Clinical Trial Failures Trouble Drug Makers, Retracts Market

Growth II-3

Safety Issues Marr Penetration of Radiolabelled CD20 Antibodies II-3

Oncologists Resort to Zevalin and Bexxar As a Last Resort II-3

Novel Action Mechanisms Bode Potential for New CD20 mAbs II-4

Future of mAbs – Smaller and Inexpensive to Produce II-4

Structurally Modified Full-Size mAbs – Next Type of mAbs to

Hit the Market II-5

MAb Fragments II-5

Major Companies in the Chase for New-Generation Technologies II-5

Next Generation CD20 mABs II-6

Comparison of Marketed and Pipeline CD20 Antibodies Based on

Action Mechanism II-6

Second Generation CD20 Antibodies II-6

Ofatumumab II-6

Veltuzumab II-7

Ocrelizumab II-7

Third Generation CD20 Antibodies II-7

AME133v II-7

TRU-015 II-7

GA101/Obinutuzumab II-7

Incidence and Prevalence of Major Targeted Indications of CD20

mAbs II-8

Rheumatoid Arthritis – A Chronic, Debilitating Disease II-8

Incidence and Prevalence Higher in Urban and Developed Regions II-8

Lymphoma Incidence and Mortality Rates On the Rise II-9

Incidence of Hodgkin's Lymphoma - High in West Asia II-9

Table 1: Age-Standardized Incidence Rates for Hodgkin's

Lymphoma in Select Countries Worldwide (2002) (includes

corresponding Graph/Chart) II-9

Table 2: Age-Standardized Mortality Rates for Hodgkin's

Lymphoma in Select Countries Worldwide (2002) (includes

corresponding Graph/Chart) II-10


PML Risks Clipping Label Expansions of Rituxan II-11

Rituxan and Ocrelizumab Show Promise in RRMS Treatment II-11

Ocrelizumab's Ouster in RA Puts Development Partners in a

Quandary II-12

Zevalin and Bexxar Sales Remain in Obscurity II-13

The Road Ahead for Zevalin II-13


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