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Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Date:8/31/2010

nces, acquisitions and mergers in the field of epigenetics since 2007 ......... 59

Table 20: Areas of focus for companies developing diagnostic tests based on epigenetics ...................60

Asuragen Inc, Austin, TX.........60

Epigenomics AG, Berlin, Germany.............60

Exiqon, Copenhagen, Denmark.................60

OncoMethylome Sciences, Durham, NC....61

Orion Genomics, Saint Louis, MO ..............61

Rosetta Genomics, Rehovot, Israel ...........61

Alliances with market leaders – Diagnostics..................61

Conclusion................ 62

Chapter 6 - Outlook & Future of Epigenetic Research 63

Executive Summary 64

Outlook & future of epigenetic research. 65

Epigenetics research now ......... 65

Figure 10: Progress in epigenetics related therapeutics and diagnostics over the next 5 years ............ 65

Therapeutic launches and new indications over the next 5 years 66

Table 21: Revenues generated by Vidaza, Dacogen and Zolinza in 2009........ 66

New combinations and a changing therapeutic paradigm in cancer 67

Table 22: Examples of clinical trials of combinations of DNMTi, HDACi and chemotherapy .................. 67

Table 23: Examples of clinical trials of drug combinations including panobinostat .........68

New diagnostic products........69

Table 24: New diagnostic products identifying epigenetic biomarkers that will be launched to the market over the next few years 69. 69

Next generation sequencing..69

Epigenetics research in 5 to 10 years time..70

Figure 11: Progress in epigenetics related therapeutics and diagnostics over the next 5 to 10 years ..... 70

Therapeutic launches..............70

Therapeutics and companion diagnostics for novel epigenetic targets 71

Epigenetics research more than 10 years from now.... 72

Figure 12: Progress in epigenetic
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