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Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Date:8/31/2010

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Table 9: Selective HDAC inhibitors....... 30

EXPERT COMMENTARY: Dr David Simmons (CSO) & Dr Gitte Neubauer (VP Research Operations), Cellzome 31. 31

Beyond DNMT and HDAC inhibition: New targets .......32

Table 10: Companies developing drugs for novel epigenetic targets.............. 33

EXPERT COMMENTARY: Dr Robert Gould, CEO, Epizyme Inc

EXPERT COMMENTARY: Martin Bonde, CEO, EpiTherapeutics

Cancer the first frontier, where next?...........35

Table 11: Companies developing therapeutics for epigenetic mechanisms in diseases other than cancer ................. 35

Non-coding RNAs....35

Table 12: Companies developing therapeutic strategies related to miRNAs... 35

Table 13: Therapeutic areas for miRNA-based therapeutic discovery............. 36

EXPERT COMMENTARY: Dr. Andreas G. Bader, Associate Director of Research, Mirna Therapeutics, Inc.37. 37

The future................. 38

Chapter 4 - Epigenetics in Clinical Diagnostics 39

Executive Summary 40

Epigenetics in clinical diagnostics.............40

Epigenetics in clinica l diagnostics.............. 41

Introduction..............41

DNA methylation patterns.........41

Table 14: Companies developing diagnostics to detect aberrant DNA methylation patterns ............... 41

Epigenomics AG...42

Figure 7: Epigenomics' development programme.. 42

OncoMethylome Sciences......43

Figure 8: OncoMethylome Sciences' development programme.. 43

Orion Genomics...44

Figure 9: Orion Genomics' product development pipeline.......... 44

Histone modifications................ 45

miRNAs. 45

Rosetta Genomics45

Table 15: Approved and developmental diagnostic products from Rosetta Genomics ..... 45

Asuragen Diagnostics.............46

Exiqon A/S............46

Table 16: Exiqon's miRNA-based diagnostic pipeline.........
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