Navigation Links
Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Date:8/31/2010

Chris Adams, Senior R&D Manager/Epigenetics, Life Technologies 15. 15

Next generation sequencing.....16

Table 1: Platforms for next generation sequencing 16

Table 2: Third generation sequencing platforms..... 17

DNA methylation.....17

Table 3: Methods for studying DNA methylation and their limitations ........... 17

Table 4: Suppliers of research tools for the study of DNA methylation............ 18

Chromatin structure and histone modifications............19

Figure 4: Schematic of a chromatin immunoprecipitation experiment ......... 19

Table 5: Suppliers of research tools for the study of histone and chromatin modifications ................... 20

microRNA................. 20

Table 6: Suppliers of research tools for the study of miRNA........ 21

Conclusion.................21

Chapter 3 - Epigenetics in Drug Discovery & Development 23

Executive Summary.24

Epigenetics in drug discovery & development.............24

Epigenetics in drug discover y & development............. 25

Introduction............. 25

Figure 5: Proteins involved in the modification of histones......... 25

Figure 6: Number of drugs targeting epigenetic mechanisms by mechanism and stage of development ................ 26

Epigenetics in cancer...................26

Epigenetic drug targets in cancer: DNA methyltransferases

Table 7: Approved drugs targeting DNMTs.............. 27

Epigenetic drug targets in cancer: HDAC inhibitors.....28

Non-selective HDAC inhibitors...................28

Table of Contents

Espicom Business Intelligence iv August 2010

Table of Contents Epigenetics: Current and Future Applications

Table 8: Pan-HDAC inhibitors in clinical development ............... 28

EXPERT COMMENTARY: Dr Bernd Hentsch, Chief Development Officer, 4SC AG

Selective HDAC inhibitors.......3
'/>"/>

SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Reportlinker Adds Clinical Laboratory Testing Volume 1: Reagents and Instruments
2. Reportlinker Adds Portable and Transport Ventilator Market Shares, Strategies, and Forecasts, Worldwide, 2010 to 2016
3. Reportlinker Adds Pharmaceutical M&A in the Asia-Pacific Region - India and China drive regional activity but Japan still dominates high value transactions
4. Reportlinker Adds Strategic Analysis of End-user Preferences in the U.S. Stem Cell Research Tools Markets
5. Reportlinker Adds Production and Market of Xylose in China
6. Reportlinker Adds Advances in Large Scale BioManufacturing and Scale-Up Production, 2nd ED
7. Reportlinker Adds European Markets for Small Joint Reconstructive Devices 2010 (15 Countries)
8. Reportlinker Adds Japanese Market for Small Joint Reconstructive Devices 2010
9. Reportlinker Adds Effective Social Media Marketing Strategies for Pharmaceutical Market
10. Reportlinker Adds Wireless Medical Technologies 2007-2010
11. Reportlinker Adds European Market for Ventilation and Airway Management Devices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 2014 This September leading clinicians in orthodontics ... Vegas for DOCtalk 2014 —a "Dynamic ... thinker and private practitioner Dr. David Sarver , ... discuss clinical and practice management efficiency and high quality ... opportunity to welcome fresh thinking and join a community ...
(Date:7/23/2014)... SUNNYVALE, Calif. , July 23, 2014 /PRNewswire/ ... devices for the transcarotid treatment of intra- and ... Michael P. Wallace to the position ... Michael will lead the company,s Research and Development ... treatment devices. Prior to joining ...
(Date:7/23/2014)... , July 23, 2014  MiMedx Group, ... developer, processor and marketer of patent-protected regenerative biomaterials ... today it has filed its initial Investigational New ... Administration ("FDA").   The IND submission, ... the Company,s initial submission for certain indications of ...
Breaking Medicine Technology:2014 DOCtalk Registration Now Open 22014 DOCtalk Registration Now Open 3Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 2Silk Road Medical Appoints Ground Breaking Innovator as Chief Technology Officer 3MiMedx Files Its Initial Investigational New Drug Application 2MiMedx Files Its Initial Investigational New Drug Application 3
... A study published in the journal ... health system, has achieved remarkable results in eliminating preventable ... keeping patients safe.  In 2003, Ascension Health set a ... Health has seen consistent improvement over the eight years ...
... AT&T * today announced that the Arkansas Department of Health ... clinic solution to help the agency more efficiently transmit flu ... the use of the application to other year-round immunization and ... As an important part of its mission to protect and ...
Cached Medicine Technology:Study Highlights Successes of Ascension Health Quality Initiative 2Arkansas Department of Health Chooses AT&T to Streamline Delivery of Public Health Programs 2Arkansas Department of Health Chooses AT&T to Streamline Delivery of Public Health Programs 3Arkansas Department of Health Chooses AT&T to Streamline Delivery of Public Health Programs 4
(Date:7/23/2014)... (PRWEB) July 23, 2014 “Unlike most ... focus on developing your own unique gifts, talents and ... and clichéd sales verbiage, “says Ja Marr Brown. ... Sales Story?" which chronicles Brown’s transformation from nearly getting ... of The Year, winning every sales contest offered and ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 The ... ratified today a robust trial for a defined ... of risk adjusting relevant quality measures for sociodemographic ... NQF policy.     , Sociodemographic factors can be socioeconomic, ... race, ethnicity, and primary language. Growing evidence ...
(Date:7/23/2014)... 23, 2014 In preparation for National ... Millennium Treatment Group is providing tips on choosing a ... society ever since man first figured out the process ... has existed since shortly thereafter. Its basis lies in ... then developing a way to combat that problem while ...
(Date:7/23/2014)... HealthDay Reporter WEDNESDAY, ... overweight American children and teens look in the mirror ... officials reported Wednesday. "Being overweight or obese is ... pressure, high cholesterol and diabetes," said lead researcher Neda ... Disease Control and Prevention,s National Center for Health Statistics. ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Inventor and ... From football games to the gas pump – sharing ... on Wednesday, July 30 at Noon. , With 24 ... has more patents than anyone in the General Assembly ... superimposed yellow line yard marker as seen on television, ...
Breaking Medicine News(10 mins):Health News:Using Your Story and Not Technique to Achieve Sales Success 2Health News:NQF Board Approves Trial Period to Test Impact of Risk Adjustment of Performance Measures for Sociodemographic Factors 2Health News:Millennium Treatment Group Offers Tips on Choosing a Reputable Treatment Center 2Health News:Millennium Treatment Group Offers Tips on Choosing a Reputable Treatment Center 3Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 2Health News:Many Obese U.S. Kids Think They're Thinner Than They Are 3Health News:Celebrating Innovation and Invention 2
... synthetic bone matrix offers hope for babies born with craniosynostosis, ... fuse too soon. Implants replacing some of the infant,s bone ... currently used to treat the condition. "The remarkable thing ... matrix changes what the cells around it do. Cells begin ...
... disease, stroke more likely for organ recipients with sleep ... News) -- Kidney transplant patients with sleep apnea are ... and stroke, Hungarian researchers say. , The study of ... moderate to severe sleep apnea, a rate similar to ...
... and costs, study finds , THURSDAY, Nov. 19 (HealthDay ... angiography is quicker, more accurate and much less expensive ... to moderate enzyme and EKG scores, according to a ... pain patients at 16 emergency rooms who were randomly ...
... 19 2009 has been a monumental year for ... from QUITPLAN Services, QuitCash Challenge, helped the 31-year-old Columbia ... The Challenge. Nearly 2,000 Minnesotans, including Doug, attempted to ... win the $5,000 grand prize. , On Thursday, November ...
... Official Statement by Teamsters General President Jim Hoffa ... Jim Hoffa issued the following statement today about the Senate ... health plans that will mean a huge middle-class tax hike ... would impose an excise tax on insurers for higher-cost health ...
... Nov. 19 Monogram Energy, Inc. ("Monogram") (Pink Sheets: ... of Triad Therapeutics, Inc. ("Triad"), which was effective as ... the Stock Purchase and Recapitalization Agreement, shareholders of Monogram ... exchange for approximately 95% ownership to the Triad shareholders ...
Cached Medicine News:Health News:Bone implant offers hope for skull deformities 2Health News:Kidney Transplant, Sleep Disorder May Add Up to Trouble 2Health News:First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM) 2Health News:First-Time Father-to-Be Quits Smoking, Wins $5,000 in The QuitCash Challenge(TM) 3Health News:Monogram Energy, Inc. Acquires Triad Therapeutics, Inc. 2
... a surgical approach to glaucoma management that ... The ciliary body (which produces aqueous humour) ... anterior or posterior segment, through the endoscope ... easily and accurately identified utilizing endoscopy. This ...
... Endoscopic CycloPhotocoagulation (ECP) is a surgical ... endoscopy and visualized laser application. The ciliary ... by the surgeon, from the anterior or ... time. The target tissues are easily and ...
... surgical approach to glaucoma management that employs ... ciliary body (which produces aqueous humour) is ... or posterior segment, through the endoscope in ... and accurately identified utilizing endoscopy. This allows ...
... a surgical approach to glaucoma management that ... The ciliary body (which produces aqueous humour) ... anterior or posterior segment, through the endoscope ... easily and accurately identified utilizing endoscopy. This ...
Medicine Products: