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Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Date:8/31/2010

Chris Adams, Senior R&D Manager/Epigenetics, Life Technologies 15. 15

Next generation sequencing.....16

Table 1: Platforms for next generation sequencing 16

Table 2: Third generation sequencing platforms..... 17

DNA methylation.....17

Table 3: Methods for studying DNA methylation and their limitations ........... 17

Table 4: Suppliers of research tools for the study of DNA methylation............ 18

Chromatin structure and histone modifications............19

Figure 4: Schematic of a chromatin immunoprecipitation experiment ......... 19

Table 5: Suppliers of research tools for the study of histone and chromatin modifications ................... 20

microRNA................. 20

Table 6: Suppliers of research tools for the study of miRNA........ 21

Conclusion.................21

Chapter 3 - Epigenetics in Drug Discovery & Development 23

Executive Summary.24

Epigenetics in drug discovery & development.............24

Epigenetics in drug discover y & development............. 25

Introduction............. 25

Figure 5: Proteins involved in the modification of histones......... 25

Figure 6: Number of drugs targeting epigenetic mechanisms by mechanism and stage of development ................ 26

Epigenetics in cancer...................26

Epigenetic drug targets in cancer: DNA methyltransferases

Table 7: Approved drugs targeting DNMTs.............. 27

Epigenetic drug targets in cancer: HDAC inhibitors.....28

Non-selective HDAC inhibitors...................28

Table of Contents

Espicom Business Intelligence iv August 2010

Table of Contents Epigenetics: Current and Future Applications

Table 8: Pan-HDAC inhibitors in clinical development ............... 28

EXPERT COMMENTARY: Dr Bernd Hentsch, Chief Development Officer, 4SC AG

Selective HDAC inhibitors.......3
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