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Reportlinker Adds Epigenetics: Current and future applications that are driving novel drug discovery
Date:8/31/2010

the company's aims and its areas of focus

Products

Core product areas, key brands, product approvals and launches

Research and Development

How much has been invested in R&D?

Where is the research based?

What alliances and agreements does the company have and with whom?

Manufacturing and Distribution

Identifying the company's manufacturing locations

Sales and marketing facilities

Agreements

With whom has the company reached agreements and what do they involve?

Key contracts awarded

Mergers, Acquisitions and Divestments

Litigation

Key Corporate Events

Contents

The Business Implications............1

Chapter 1 - Epigenetics Defined 3

Executive Summary...4

Epigenetics defined..................4

Epigenetics de fined ..... 5

Epigenetic mechanisms................6

DNA methylation...6

Figure 1: Schematic showing the epigenetic mechanisms of DNA methylation and histone modification .................. 6

Chromatin remodelling and histone modifications .......7

Figure 2: Examples of covalent histone post-translational modifications ....... 7

Non-coding RNA....8

Figure 3: miRNA processing pathway... 8

Unravelling the power of epigenetics............9

EXPERT COMMENTARY: Professor Stephan Beck, University College London Cancer Institute

Consortia for the study of epigenomics.........10

Which epigenomes and what to study? .....10

Applications of epigenomic data..................10

New opportunities for biomarker discovery and drug targeting

Conclusion and report outline...................11

Chapter 2 - Technical Challenges in Epigenetic R&D 13

Executive Summary.14

Technical challenges in epigenetic R&D....14

Technical challenges in epigenetic R&D..... 15

EXPERT COMMENTARY: Dr
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SOURCE Reportlinker
Copyright©2010 PR Newswire.
All rights reserved

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