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Reportlinker Adds Drug Delivery in Central Nervous System Diseases - technologies,markets and companies

ides 118

High-flow microinfusion into the brain parenchyma 119

Systemic administration of peptide nucleic acids 119

Introduction of antisense compounds into the CSF Pathways 119

Intrathecal administration of antisense compounds 120

Intracerebroventricular administration of antisense oligonucleotides 120

Nanoparticle-based delivery of antisense therapy to the CNS 121

Methods of delivery of ribozymes 121

Delivery aspects of RNAi therapy of CNS disorders 122

Delivery of siRNA to the CNS 122

Future drug delivery strategies applicable to the CNS 122

5.Drug Delivery in the Treatment of CNS Disorders 125

Parkinson's disease 125

Drug delivery systems for Parkinson's disease 126

Duodenal levodopa infusion 128

Transdermal drug delivery for PD 128

Transdermal dopamine agonists for Parkinson's disease 128

Transdermal administration of other drugs for Parkinson's disease 130

Intracerebral administration of GDNF 130

Cell therapy for Parkinson's disease 130

Human dopaminergic neurons for PD 132

Graft survival-enhancing drugs 132

Xenografting porcine fetal neurons 132

Encapsulated cells for PD 133

Stem cells for PD 133

Engineered stem cells for drug delivery to the brain in PD 135

Human retinal pigment epithelium cells for PD 135

Delivery of cells for PD 136

Gene therapy for Parkinson disease 136

Rationale 136

Techniques of gene therapy for PD 137

Prospects of gene therapy for Parkinson's disease 140

Companies developing gene therapy for PD 141

RNAi therapy of Parkinson's disease 141

Alzheimer disease 142

Drug delivery for Alzheimer disease 142

Blood-brain partitioning of an AMPA receptor modulator 143

Clearing amyloid through the BBB 143

Delivery of the passive antibody directly to the brain 143

Delivery of thyro

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