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Reportlinker Adds Drug Delivery in Central Nervous System Diseases - technologies,markets and companies
Date:9/7/2010

S 100

Animal models for testing drug delivery 100

Screening for drug-P-gp interaction at BBB 101

4.Delivery of Cell, Gene and Antisense Therapies to the CNS 103

Introduction 103

Cell therapy of neurological disorders 103

Methods for delivering cell therapies in CNS disorders 103

Encapsulated cells 104

Genetically modified stem cells for metachromatic leukodystrophy 105

CNS neotissue implant 105

CNS delivery of cells by catheters 105

Subarachnoid delivery of stem cells 106

Intravascular administration 106

Gene therapy techniques for the nervous system 107

Introduction 107

Methods of gene transfer to the nervous system 108

AAV vector mediated gene therapy for neurogenetic disorders 109

Ideal vector for gene therapy of neurological disorders 109

Promoters of gene transfer 109

Routes of delivery of genes to the nervous system 110

Direct injection into CNS 110

Introduction of the genes into cerebral circulation 111

Introduction of genes into cerebrospinal fluid 111

Intravenous administration of vectors 111

Delivery of gene therapy to the peripheral nervous system 112

Cell-mediated gene therapy of neurological disorders 112

Neuronal cells 112

Neural stem cells and progenitor cells 112

Astrocytes 112

Cerebral endothelial cells 113

Implantation of genetically modified encapsulated cells into the brain 113

Genetically modified bone marrow cells 113

Nanoparticles as non-viral vectors for CNS gene therapy 114

Applications of gene therapy for neurological disorders 114

Companies involved in cell/gene therapy of neurological disorders 115

Antisense therapy of CNS disorders 116

Delivery of antisense oligonucleotides to the CNS 117

Delivery of oligonucleotides cross the BBB 118

Cellular delivery systems for oligonucleot
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