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Reportlinker Adds Drug Delivery in Central Nervous System Diseases - technologies,markets and companies
Date:9/7/2010

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Increasing the permeability (opening) of the BBB 65

Osmotic opening of the BBB 65

Focal disruption of BBB by ultrasound 65

Chemical opening of the BBB 66

Cerebral vasodilatation to open the BBB 66

Use of nitric oxide donors to open the BBB 66

Manipulation of the sphingosine 1-phosphate receptor system 67

Pharmacological strategies to facilitate transport across the BBB 67

2B-Trans™ technology 67

ABC afflux transporters and penetration of the BBB 68

Carrier-mediated drug delivery across the BBB 68

G-Technology® 69

Glycosylation Independent Lysosomal Targeting 70

Inhibition of P-glycoprotein to enhance drug delivery across the BBB 70

Modification of the drug to enhance its lipid solubility 70

Monoclonal antibody fusion proteins 71

Neuroimmunophilins 72

Peptide-mediated transport across the BBB 72

Prodrug bioconversion strategies and their CNS selectivity 73

Role of the transferrin-receptor system in CNS drug delivery 74

Transport of small molecules across the BBB 74

Transport across the BBB by short chain oligoglycerolipids 74

Transvascular delivery across the BBB 75

Trojan horse approach 75

Use of receptor-mediated transocytosis to cross the BBB 76

Cell-based drug delivery to the CNS 77

Activated T lymphocytes 78

Microglial cells 78

Neural stem cells 78

Drug delivery to the CNS by using novel formulations 78

Crystalline formulations 78

Liposomes 79

Monoclonal antibodies 80

Microspheres 80

Microbeads 81

Brain-targeted chemical delivery systems 81

Nanotechnology-based drug delivery to CNS 82

Nanoparticles for drug delivery across the BBB 82

Penetration of BBB by nanoparticles coated with polysorbate 80 83

NanoDel? technology for crossing the BBB 83

Masking BBB-limiting charact
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