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Reportlinker Adds Drug Delivery in Central Nervous System Diseases - technologies,markets and companies
Date:9/7/2010

44

Central nervous system injuries 44

Epilepsy 45

Cerebrovascular disease 45

Infections 46

Autoimmune disorders 46

BBB and primary brain tumors 46

BBB and cerebral metastases 47

Testing permeability of the BBB 47

In vitro models of BBB 47

In vivo study of BBB 48

Brain imaging 48

In silico prediction of BBB 49

Relevance of the BBB penetration to pharmacological action 50

BBB penetration and CNS drug screening 51

CERENSESM 51

Transthyretin monomer as a marker of blood-CSF barrier disruption 51

Evaluation of BBB permeability by brain imaging 51

Biomarkers of disruption of blood-brain barrier 52

Future directions for research on the BBB 52

Application of genomics and proteomics to the study of BBB 53

Use of neural stem cells to construct the blood brain barrier 53

Strategies to cross the BBB 54

3.Methods of Drug Delivery to the CNS 55

Introduction 55

Routes of drug delivery to the brain 56

Delivery of drugs to the brain via the nasal route 56

Nasal delivery of insulin-like growth factor-I 57

Nasal delivery of midazolam 57

Nasal delivery of hypocretin 58

Intranasal administration of IFN beta-1b 58

Nasal delivery of thyrotropin-releasing hormone by nanoconstructs 58

Nasal delivery of neuroprotective drugs for stroke 59

Transdermal drug delivery for neurological disorders 59

Drug delivery to the brain via inner ear 60

Invasive neurosurgical approaches 60

Intraarterial drug delivery to the brain 60

Direct injection into the CNS substance or CNS lesions 61

Intraventricular injection of drugs 61

Intrathecal drug delivery 62

Retrograde delivery to the brain via the epidural venous system 63

Devices for drug delivery to the CNS 63

Strategies for drug delivery to the CNS across the BBB 64<
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