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Reportlinker Adds Drug Delivery in Central Nervous System Diseases - technologies,markets and companies
Date:9/7/2010

p>Dopamine receptors 23

GABA receptor channels 24

Glutamate receptor channels 24

Non-competitive NMDA antagonists 24

Serotonin receptors 25

G-protein coupled receptors 25

In vivo study of drug action in the CNS in human patients 25

Electroencephalography 25

Brain imaging 26

Chronopharmacology as applied to the CNS 26

2.Blood Brain Barrier 29

Introduction 29

Features of the blood-brain barrier relevant to CNS drug delivery 29

The neurovascular unit 29

Functions of the BBB 30

BBB as an anatomical as well as physiological barrier 30

BBB as a biochemical barrier 31

Genomics and proteomics of BBB 31

Other neural barriers 32

Blood-cerebrospinal fluid barrier 32

Blood nerve barrier 32

Blood-retinal barrier 32

Blood-labyrinth barrier 32

Passage of substances across the blood-brain barrier 33

Transporters localized in the BBB 33

Glucose transporter 34

Amino acid transporters 35

Ionic transporter 35

Efflux transport systems 35

BBB-specific enzymes 36

Receptor-mediated transcytosis 37

Lysophosphatidic acid-mediated increade in BBB permeability 37

Folate transport system 38

Molecular biology of the BBB 38

Transport of peptides and proteins across the BBB 38

Passage of leptin across the BBB 38

Passage of cytokines across the BBB 39

Passage of hormones across the BBB 39

Passage of enzymes across the BBB 40

Drugs that cross the BBB by binding to plasma proteins 40

Current concepts of the permeability of the BBB 40

Factors that increase the permeability of the BBB 41

BBB disruption as adverse effect of vaccines for CNS disorders 41

CNS disorders that affect the permeability of BBB 42

Neurodegenerative disorders 43

Mitochondrial encephalopathies 44

Multiple sclerosis
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