Date:9/7/2010

otal CNS market and the share of drug delivery technologies. Starting with the market values for the year 2009, projections are made to the years 2014 and 2019. The markets values are tabulated according to therapeutic areas, technologies and geographical areas. Unmet needs for further development in CNS drug delivery technologies are identified according to the important methods of delivery of therapeutic substances to the CNS. Finally suggestions are made for strategies to expand CNS delivery markets. Besides development of new products, these include application of innovative methods of delivery to older drugs to improve their action and extend their patent life.

Profiles of 71 companies involved in drug delivery for CNS disorders are presented along with their technologies, products and 69 collaborations. These include pharmaceutical companies that develop CNS drugs and biotechnology companies that provide technologies for drug delivery. A number of cell and gene therapy companies with products in development for CNS disorders are included. References contains over 400 publications that are cited in the report. The report is supplemented with 51 tables and 9 figures.

TABLE OF CONTENTS0.Executive Summary 15

1.Basics of Drug Delivery to the Central Nervous System 17

Introduction 17

Historical evolution of drug delivery for CNS disorders 17

Neuroanatomical and neurophysiological basis of drug delivery 18

The cerebrospinal fluid 18

The extracellular space in the brain 19

Neurotransmitters 19

Neuropharmacology relevant to drug delivery 21

Introduction to neuropharmacology 21

Pharmacokinetics 21

Absorption and distribution of drugs 21

Drug metabolism and elimination 22

Pharmacodynamics 22

Receptors 22

Sites of drug action in the CNS 22

Receptors coupled to guanine nucleotide binding proteins 23

Acetylcholine receptor channels 23

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