Navigation Links
Reportlinker Adds Competitor Analysis: PI3K-AKT-mTOR Inhibitors
Date:10/16/2009

drugs targeted to the four PI3K class I isoforms would be too toxic for use in cancer therapy due to effects on physiologic signaling. Since that time, studies have delineated the roles of these four isoforms in nonpathologic signaling as well as their roles in cancer. An extensive effort has gone into developing agents that inhibit one or more PI3K isoforms, e.g. alpha and beta, as well as closely related proteins implicated in cancer. These agents have proved to be tolerable and therapeutically beneficial in animal studies, and a number are in clinical testing.

Numerous components of the PI3K pathway play an important role in the expression and activation of inflammatory mediators, inflammatory cell recruitment, immune cell function, airway remodelling and corticosteroid insensitivity in asthma. More recently studies exploring the specific roles of different PI3K catalytic subunit isoforms in asthma have been initiated. Several of these have highlighted the importance of the delta isoform as a novel target for therapeutic intervention in asthma.

Two mTOR complexes have been characterized, termed mTORC1 (mTOR complex-1) and mTORC2. mTORC1 phosphorylates the hydrophobic motif of S6K, whereas mTORC2 phosphorylates the hydrophobic motif of Akt and SGK. The central role of mTOR in controlling key cellular growth and survival pathways has sparked interest in discovering mTOR inhibitors that bind to the ATP site and therefore target both mTORC2 and mTORC1 (mTORC2 is resistant to rapamycin).

The report includes a compilation of current active projects in research and development of PI3K-AKT-mTOR inhibitors in oncology and other indications. In addition, the report lists company-specific R&D pipelines of PI3K-AKT-mTOR inhibitors. Competitor projects are listed in a tabular format providing information on:

  • Drug Codes,
  • Target / Mechanism of Action,
  • Class of Compound,
  • Company,
  • Product Categ
    '/>"/>

SOURCE Reportlinker
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Reportlinker Adds Chugai Pharmaceutical Co. Ltd: PharmaVitae Profile
2. Reportlinker Adds Allergan Inc.: PharmaVitae Profile
3. Reportlinker Adds Pharma 101: An Overview of the Life Sciences Industry (Analyst Insight)
4. Reportlinker Adds Global Top 10 Chemical Companies -- Industry, Financial and SWOT Analysis
5. Reportlinker Adds The Middle Eastern Pharmaceutical Market Outlook To 2014: Policy environment, market structure, competitive landscape, growth opportunities
6. Reportlinker Adds Global Anesthesia and Respiratory Devices Market Analysis and Forecasts to 2015
7. Reportlinker Adds Global Drug Manufacturing Industry Outlook to 2010: Marketing and Sales Strategies and the Impact of Recession and Recovery
8. Reportlinker Adds Computer Assisted Coding Of Medical Information Market Shares, Strategies, and Forecasts 2008 to 2014
9. Reportlinker Adds Reinventing Pharmaceutical Sales Forces
10. Reportlinker Adds Global Medical Devices Industry Outlook to 2010: Marketing And Sales Strategies And The Impact of Recession And Recovery
11. Reportlinker Adds Drug Delivery Partnering Agreements in Pharma and Biotech
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/28/2015)... 28, 2015  Based on its ongoing analysis ... recognizes Lexmark Healthcare with the 2015 ... of the Year in Healthcare Content Management. In ... next level of interoperability and cost efficiency, Lexmark ... up with large-scale product development and portfolio integration ...
(Date:5/28/2015)... , May 28, 2015  Freedom Meditech, Inc., a ... chronic diseases from current blood-based standards to early and ... $4.8 million in a Series C financing. The company ... $14 million since founded. The company has also appointed ... and a member of the company,s board of directors. ...
(Date:5/28/2015)... 2015   Clementia Pharmaceuticals, Inc. today ... second part (Part B) of its natural history ... a rare, severely disabling congenital myopathy characterized by ... that result in the formation of new, abnormal ... The multi-center, non-interventional, two-part longitudinal study ...
Breaking Medicine Technology:Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 2Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 3Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 4Frost & Sullivan Acknowledges Lexmark Healthcare's Energy, Creativity, and Diligence in Developing the Leading Next-Generation Healthcare Content Management Platform 5Freedom Meditech Raises $4.8 Million and Appoints John Gerace as Chief Executive Officer 2Freedom Meditech Raises $4.8 Million and Appoints John Gerace as Chief Executive Officer 3Freedom Meditech Raises $4.8 Million and Appoints John Gerace as Chief Executive Officer 4Clementia Advances Natural History Study of Patients with Fibrodysplasia Ossificans Progressiva 2Clementia Advances Natural History Study of Patients with Fibrodysplasia Ossificans Progressiva 3
... Reported Safety & Tolerability Profile,in Subjects with ... CHICAGO, June 25 /PRNewswire-FirstCall/ -- Phase III ... of the American Diabetes,Association demonstrated that saxagliptin, ... Bristol-Myers,Squibb Company (NYSE: BMY) and AstraZeneca (NYSE: ...
... Findings Reported Safety & Tolerability Profile,in Subjects ... --, CHICAGO, June 25, 2007 /PRNewswire-FirstCall/ -- ... annual meeting of the American Diabetes,Association demonstrated ... development by Bristol-Myers,Squibb Company and AstraZeneca , ...
Cached Medicine Technology:Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 2Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 3Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 4Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 5Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 6Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 2Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 3Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 4Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 5Data Demonstrated Saxagliptin Added to Metformin Improved Glycemic,Control in Subjects with Type 2 Diabetes Compared to Metformin,Alone 6
(Date:5/28/2015)... May 28, 2015 According to ... http://www.idataresearch.com ), the shoulder reconstruction device market, was ... bone & joint market in 2014. This trend ... procedures in the U.S. due to increased surgeon ... technology resulting in greater patient outcomes. Therefore, surgeons ...
(Date:5/28/2015)... The connected car is gaining more traction ... vehicles have some iteration of a connected offering in ... insurance companies as the data collected can be used ... insurance (UBI). This is the primary reason that 800+ ... 2015 Conference & Exhibition. , Andrew Pym, TU ...
(Date:5/28/2015)... lifeIMAGE announced today that ... led by Cambia Health Solutions (Portland, Ore.), ... health care by creating a person-focused and economically sustainable ... for exchanging medical imaging, will use this financing to ... breadth of its network capabilities and implement the next ...
(Date:5/28/2015)... A bucket list should include dreams, goals, destinations, ... the bucket list can be tiny, small, medium, large, ... owner wants to happen in their own lifetime. ... to making this list. Bucket list ideas might ... seeing the Grand Canyon on horseback, skydiving, visiting Scotland, ...
(Date:5/28/2015)... May 28, 2015 The MIT Sloan ... study featuring Healthcare IQ. Members of the MIT CISR ... management team to develop the case study about Healthcare ... analytics. , The case study, ‘Healthcare IQ: Competing as ... from its beginning as a hospital financial software provider ...
Breaking Medicine News(10 mins):Health News:DePuy Synthes and Biomet Lead Fastest Growing U.S. Shoulder Reconstruction Device Market 2Health News:DePuy Synthes and Biomet Lead Fastest Growing U.S. Shoulder Reconstruction Device Market 3Health News:TU-Automotive: North America’s Leading Insurers Head to Chicago as Connected Car Motor Insurance Shifts up a Gear 2Health News:TU-Automotive: North America’s Leading Insurers Head to Chicago as Connected Car Motor Insurance Shifts up a Gear 3Health News:Cambia Health Solutions Leads New Round of Investment in lifeIMAGE 2Health News:Cambia Health Solutions Leads New Round of Investment in lifeIMAGE 3Health News:Cambia Health Solutions Leads New Round of Investment in lifeIMAGE 4Health News:Healthcare IQ, the “Switzerland” of Healthcare Spend Analytics, Featured in MIT Case Study 2Health News:Healthcare IQ, the “Switzerland” of Healthcare Spend Analytics, Featured in MIT Case Study 3
... of Monte Carlo Dose Calculation Software Announced ... Radiation Oncology Meeting in Barcelona, BARCELONA, Spain, Sept. ... leader in the field of radiosurgery,announced today that its ... the U.S. Food and Drug Administration and is,now commercially ...
... Severe Bleeding, BETHESDA, Md., Sept. 10 A ... in moderate to severe wounds has received FDA clearance ... news for soldiers,and civilians alike, because the product is ... "The FDA,s speedy approval of WoundStat means that ...
... DaVita Inc.,(NYSE: DVA ) announced today that ... Partners, Inc. for approximately $65 million in cash.,HomeChoice, based ... services to patients with acute or chronic conditions that ... suite. HomeChoice has reported,approximately $37 million in trailing twelve ...
... healthcare,providers follow proven protocols could reduce the risks ... to a study reported in,a cardiovascular surgery supplement ... A study of the American Heart Association,s Get ... how hospitals carry out,many of the association,s secondary ...
... and MPRO Honor Hospital Excellence, KALAMAZOO, Mich., ... received the Governor,s Award for Improving Patient,Safety and ... addition, 29,Critical Access hospitals statewide received the Governor,s ... in the Critical Access,Hospital Setting. The Governor presents ...
... 10 Give an Hour, a,non-partisan, non-profit organization ... their loved ones, announces that there are 575,providers, ... Armed Forces,and their families., In an effort ... the military through the military health care system, ...
Cached Medicine News:Health News:Accuray Receives FDA Clearance for New Dose Calculation Technique for Body Radiosurgery 2Health News:Accuray Receives FDA Clearance for New Dose Calculation Technique for Body Radiosurgery 3Health News:Accuray Receives FDA Clearance for New Dose Calculation Technique for Body Radiosurgery 4Health News:Accuray Receives FDA Clearance for New Dose Calculation Technique for Body Radiosurgery 5Health News:Life-Saving News for Battlefield Soldiers & Wounded Civilians 2Health News:Life-Saving News for Battlefield Soldiers & Wounded Civilians 3Health News:DaVita Acquires Majority Stake in HomeChoice Partners, Inc. 2Health News:American Heart Association Surgical Supplement Journal Report: Appropriate Hospital Discharge System Can Prevent Future Cardiac Events 2Health News:American Heart Association Surgical Supplement Journal Report: Appropriate Hospital Discharge System Can Prevent Future Cardiac Events 3Health News:American Heart Association Surgical Supplement Journal Report: Appropriate Hospital Discharge System Can Prevent Future Cardiac Events 4Health News:Michigan Hospitals Receive Governor's Award 2Health News:Michigan Hospitals Receive Governor's Award 3Health News:National Non-Profit Organization Offers Free Mental Health Services to Military and Military Families 2
... Analyzer provides youwith new, exciting possibilities for ... WASCA Analyzeranalyzes the optical properties of the ... retina. In addition to refractive values, the ... which were largely ignored in the past. ...
... air flow modules are the economic solution ... work areas, which nevertheless present all the ... The modules can be easily installed in ... necessary to create sterile environment, without modifications ...
BRAT 2 Autologous Blood Recovery System gives performance, speed, versatility, and quality processing. , ,The BRAT 2 is now available with on-board Vacuum, programmability, plasma sequestration, Data...
The Wixson Hip Positioner is used for stable positioning of a patient during total hip and revision surgery. It is designed to be placed on top of the operating table....
Medicine Products: