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Reportlinker Adds 2010 Pharmaceuticals Research Review
Date:12/14/2010

LMOLOGY DISEASE 9

Established Drug Classes in Ophthalmology 10

Emerging Drug Classes 10

VEGF-Trap Eye 10

Combination Therapies 11

Competition between VEGF Inhibitors in Wet AMD 11

TABLE 2 NOTABLE EVENTS IN LUCENTIS VERSUS AVASTIN: PREVIOUS AND EXPECTED 12

Expected Outcome of CATT trial: Avastin v. Lucentis 12

Genetic Specifications of Ophthalmic Disease 13

TABLE 3 SUMMARY OF KNOWN GENES INFLUENCING DISEASE 14

Summary Pipeline of Drugs in Development 14

TABLE 4 RECENTLY APPROVED DRUGS, 2009 15

TABLE 5 SUMMARY PIPELINE FORECAST, 2012-2014 15

INDUSTRY STRUCTURE AND COMPETITIVE ANALYSIS 15

INDUSTRY STRUCTURE 15

Market Concentration and Price Sensitivity 16

TABLE 6 COMPANY BY DISEASE CLASS, 2009 REVENUE ($ MILLIONS) 17

Competitive Factors 17

TABLE 7 LARGE REVENUE, BRANDED DRUG SALES COMING OFF PATENT, 2009 18

Chapter-3: GLOBAL MARKETS FOR ORPHAN DRUGS (PHM038C)

INTRODUCTION 19

STUDY GOAL AND OBJECTIVES 19

REASONS FOR DOING THE STUDY 20

INTENDED AUDIENCE 20

SCOPE OF REPORT 21

INFORMATION SOURCES AND METHODOLOGY 21

AUTHOR'S CREDENTIALS 22

RELATED REPORTS FROM BCC RESEARCH 22

SUMMARY 23

TABLE 8
GLOBAL ORPHAN DRUGS DEMAND BY VALUE, THROUGH 2014 ($ MILLIONS) 24

FIGURE 2 GLOBAL ORPHAN DRUGS DEMAND BY VALUE, 2008-2014 ($ MILLIONS) 25

OVERVIEW 25

DEFINITION OF AN ORPHAN DRUG 25

HISTORY OF ORPHAN DRUG LEGISLATION 26

First Legislation on Orphan Drugs 26

Amendments to the ODA 26

Bills Passed in 2002 Increased Funding and Established the Office of Rare Diseases 26

Orphan Drug Legislation — Global Status 26

INCENTIVES FOR ORPHAN DRUG DEVELOPMENT 27

THE NEED FOR INCENTIVES 27

TABLE 9 NUMBER OF ORPHAN DRUG DESIGNATIONS AND APPROVALS PER YEAR BY U.S. FD
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