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Reportlinker Adds 2010 Pharmaceuticals Research Review
Date:12/14/2010

E, AND OTHER DRUG COMPANIES, 2009 (%) 148

FIGURE 15 (CONTINUED) 149

OVERVIEW OF SCIENTIFIC BACKGROUND, AND SIGNIFICANCE OF UPS RESEARCH 149

UBIQUITINATION PHENOMENA AND ITS MAJOR COMPONENTS 149

Enzymatic Components as Possible Drug Targets 149

TABLE 47 ENZYMATIC COMPONENTS OF UBIQTUINATION/ DEUBIQUITINATION REACTION 150

FIGURE 16 ENZYMATIC STEPS IN UBIQUITINATION REACTION 150

FIGURE 17 HIERARCHICAL STRUCTURE OF UPS 151

Chain Topology as a Signaling Pathway 151

PROTEASOME MACHINERY 152

STRUCTURE AND FUNCTION 152

PROTEASOME AS A TARGET FOR DRUG DISCOVERY 153

UBIQUITIN-LIKE MODIFIERS (UBLS) 153

TABLE 48 UBLS, THEIR FUNCTION AND ASSOCIATED PATHOLOGY WITH THEIR DYSFUNCTION 154

MAJOR DRUG DEVELOPMENT AND PRODUCTS IN THE UPS RESEARCH FIELD 155

INDUSTRY OVERVIEW 155

Proteasome as a Drug Discovery 155

Velcade: The First UPS Product 155

Chemical Structure of Velcade and Its Mechanism of Action 156

FIGURE 18 CHEMICAL STRUCTURE OF BORTEZOMIB 156

Pharmacodynamics, Administration, and Side Effects 156

Velcade Sales Market 157

Overview 157

TABLE 49 U.S. STATISTICS FOR HEMATOLOGICAL MALIGNANCIES, 2009 (NUMBER) 157

MM Symptoms and Treatment 158

General Treatment for MM Today 158

TABLE 50 PROJECTED SIZE OF THE WORLDWIDE MM DRUG MARKET, 2009 AND 2018 ($ BILLIONS) 159

NHL and Mantle Cell Lymphoma 159

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Treatments for Mantle Cell Lymphoma and Other NHL 159

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CHOP Therapy 159

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MabThera/Rituxan 159

Current Major Market Participants in MM Treatment and Sales Forecast 160

Millennium Pharmaceuticals (a Subsidiary of Takeda) 160

TABLE 51 U.S. AND WORLDWIDE NET SALES OF VELCADE, THROUGH 2015 ($ MILLIONS) 160

FIGURE 19 U.S. AND WORLDWIDE NET SALES OF VELCADE, 2007-2015 ($ MIL
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