Navigation Links
Repligen Announces Plans to Initiate a Phase 2b Trial for RG2417 in Bipolar Disorder
Date:6/12/2008

Reports Full Assessment of Data from Positive Phase 2a Trial

WALTHAM, Mass., June 12 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN) today announced that based on feedback from the Food and Drug Administration, the Company plans to initiate a Phase 2b clinical trial of RG2417, an oral formulation of uridine, in patients with bipolar disorder later this year. This will be a multi-center, parallel arm placebo-controlled, clinical trial in which approximately 150 patients with bipolar disorder will receive either RG2417 or a placebo twice a day for eight-weeks. This study is designed to assess the efficacy and safety of RG2417 on the symptom of depression as measured by the Montgomery-Asberg Depression Rating Scale (MADRS). Gary S. Sachs, M.D., founder and director of the Bipolar Clinic and Research Program at the Massachusetts General Hospital and an Associate Professor of Psychiatry at the Harvard Medical School will be the Principal Investigator of this study.

Repligen previously reported positive initial results from a Phase 2a clinical trial of RG2417 in patients with bipolar disorder. We have now completed our assessment of the data and have found that patients with a history of more frequent symptoms demonstrated greater improvements when treated with RG2417 than patients without a history of frequent symptoms. For example, patients with more than 5 episodes of depression over their entire life (n=50) demonstrated greater improvements in their symptoms of depression compared to patients with 5 or fewer lifetime episodes of depression. From weeks 2-6 of treatment, the patients with more than 5 lifetime episodes of depression who received RG2417 had an average improvement on MADRS of 5.5 points over place
'/>"/>

SOURCE Repligen Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Repligen Reports Positive Phase 2a Clinical Trial Results of RG2417 for Symptoms of Bipolar Disorder
2. Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging
3. Repligen Receives FDA Fast Track Designation for RG1068 for Pancreatic Imaging
4. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
5. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
6. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
7. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
8. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
9. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
10. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
11. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 16, 2014 Astellas announced today it ... Communications & Advocacy, Urology in the Americas. Noland will ... Advocacy Margaret Long. In this role, Noland will be ... patient and advocacy organizations, as well as collaborating ... initiatives. Noland,s appointment is the latest phase in ...
(Date:9/16/2014)... 2014 /PRNewswire-iReach/ -- Dan York has been ... of the RTD ® Advanced Wound Care Dressing, ... sales presence in the U.S. Under York,s leadership, GWM ... field sales representatives in new sales territories that will ... add up to 20 sales representatives in major metropolitan ...
(Date:9/16/2014)... DIEGO , Sept. 16, 2014  Denovo ... enzastaurin, a late-stage oncology drug, from Eli Lilly ... to develop, manufacture and commercialize enzastaurin globally, including ... data, and information. Lilly developed ... Phase 2 and Phase 3 clinical trials for ...
Breaking Medicine Technology:Christy Noland to Lead Urology Advocacy and Communications for Astellas 2GWM Products, LLC, announces U.S. market expansion. Dan York added as Director of Sales as part of nationwide growth initiative. 2Denovo Biopharma Acquires Late-Stage Oncology Drug From lilly For Development As A Personalized Medicine 2
... 2011 Reportlinker.com announces that a new market research ... Gastric Cancer Drug Discoveries: what the future holds ... Original analysis of the clinical potential ... candidates put into current market context Original ...
... 2011 Reportlinker.com announces that a new market research report ... Stent Market Outlook to 2016 http://www.reportlinker.com/p0483600/The-Drug-Eluting-Stent-Market-Outlook-to-2016.html ... DES market has seen tremendous growth since the introduction of ... on the release of clinical data that indicated a link ...
Cached Medicine Technology:Reportlinker Adds Gastric Cancer Drug Discoveries: what the future holds 2Reportlinker Adds Gastric Cancer Drug Discoveries: what the future holds 3Reportlinker Adds Gastric Cancer Drug Discoveries: what the future holds 4Reportlinker Adds Gastric Cancer Drug Discoveries: what the future holds 5Reportlinker Adds the Drug-Eluting Stent Market Outlook to 2016 2Reportlinker Adds the Drug-Eluting Stent Market Outlook to 2016 3Reportlinker Adds the Drug-Eluting Stent Market Outlook to 2016 4
(Date:9/16/2014)... 2014 Keep that sexy decolletage as you ... neck. , "The Face Whisperer Neck & Decollete Cream ... Heshelow, founder of Sublime Beauty®. "It contains rich ingredients to ... and arnica." , A special ingredient is Argireline, known as ... rich anti-aging cream comes in an airless pump bottle, and ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Today, ... published new information on transitioning employees to individual ... with the Affordable Care Act (ACA) in full ... be steering some or all of their employees ... surprise. With guaranteed issue plans, coverage for pre-existing ...
(Date:9/16/2014)... the well-known wedding dress manufacturer and retailer, has unveiled ... Additionally, the firm has launched a promotion for its ... up to 62 percent off. , All ... won a lot of positive reviews for its high-quality ... big savings on many other items, including corset bridesmaid ...
(Date:9/16/2014)... 16th, 2014; San Francisco) In a healthcare ... weighed against potential benefit, a Yale study has ... less-aggressive radiation procedures on elderly women with early-stage ... presented at the 56th annual conference of the ... (Abstract 131: Evaluating National Practice in Radiotherapy for ...
(Date:9/16/2014)... Recently, iFitDress.com, one of the most famous dress suppliers ... evening gown collection. According to the company’s sales manager, ... (up to 69% off) at present. Additionally, all the company’s ... am a frequent caller of your site. I like your ... feel quite happy. All items are of good quality. I ...
Breaking Medicine News(10 mins):Health News:15% Off Face Whisperer® Neck & Decollete Cream Now from Sublime Beauty; Care For This Delicate Skin That Shows Age Quickly 2Health News:Zane Benefits Publishes New Information on Transitioning Employees to Individual Health Insurance 2Health News:New Elegant Evening Wear Assortment Released By UWDress.com 2Health News:iFitDress.com: One Shoulder Evening Gown Collection Unveiled Online 2
... a 60-cm-long sword that had been thrust through the nose ... ear, news reports said Wednesday. ,Ronnachai Tiemsanguan, 16, ... sword's removal from his face in an operation that took ... newspaper. ,Ronnachai received his sword wound Saturday when ...
... in the field of conducting tasks that involve spatial ... light turns green. , Researcher Eric Schumacher, ... Technology and colleagues, were surprised when they conducted MRI ... ,The researchers were testing the notion that areas ...
... suggests that ovarian cancer cells form by hijacking a ... Scientists at the Georgia Institute of Technology and the ... involved in the development of fallopian tubes and is ... ovarian tissue. The discovery not only provides a new ...
... Barbara, California – March 6, 2007 -- A team ... Berkeley and StrataGent// Life Sciences, of Los Gatos, California, ... to deliver protein drugs into the skin without the ... The research was published online today in the Proceedings ...
... It's already been established that type 2 diabetes increases the ... also a link between type 1 diabetes and this type ... but still, those with type 1 diabetes have a likelihood ... in non-diabetics. This is similar to the risk those with ...
... International Narcotics Control Board (INCB) – an independent body ... control// standards – is calling for the danger of ... ,In its annual report, the Vienna-based organisation ... drugs are not illegally manufactured or diverted from authorised ...
Cached Medicine News:Health News:Same Areas of the Brain Prepare for and Respond to a Stimulus, Say Experts 2Health News:Ovarian Cancer May Mimic Fallopian Tube Formation 2Health News:Ovarian Cancer May Mimic Fallopian Tube Formation 3Health News:Researchers Design Pulsed Mircrojet System to Deliver Protein Drugs Without Pain or Bruising 2Health News:Flood of Fake Drugs Must Be Stopped, Warns UN 2
... The 50 psi MaxiCompressor, the ... to run 24 hours a ... It features a tamper-proof locking ... unintentional increases or decreases in ...
... popular and competitively priced SportNeb features ... Design enhancements include a neb kit ... black carry bag. The color SportNeb ... SportNeb also offers private labeling opportunities ...
... Treatment Compressor (230V). Same performance specifications as ... wide selection of adult and pediatric mask/nebulizer ... in a variety of international voltages and ... important part of managingthe disease state of ...
The 16 liter Laparoscopy Insufflator combines high safety and precise pressure control with simple operation....
Medicine Products: