Navigation Links
Repligen Announces Plans to Initiate a Phase 2b Trial for RG2417 in Bipolar Disorder
Date:6/12/2008

Reports Full Assessment of Data from Positive Phase 2a Trial

WALTHAM, Mass., June 12 /PRNewswire-FirstCall/ -- Repligen Corporation (Nasdaq: RGEN) today announced that based on feedback from the Food and Drug Administration, the Company plans to initiate a Phase 2b clinical trial of RG2417, an oral formulation of uridine, in patients with bipolar disorder later this year. This will be a multi-center, parallel arm placebo-controlled, clinical trial in which approximately 150 patients with bipolar disorder will receive either RG2417 or a placebo twice a day for eight-weeks. This study is designed to assess the efficacy and safety of RG2417 on the symptom of depression as measured by the Montgomery-Asberg Depression Rating Scale (MADRS). Gary S. Sachs, M.D., founder and director of the Bipolar Clinic and Research Program at the Massachusetts General Hospital and an Associate Professor of Psychiatry at the Harvard Medical School will be the Principal Investigator of this study.

Repligen previously reported positive initial results from a Phase 2a clinical trial of RG2417 in patients with bipolar disorder. We have now completed our assessment of the data and have found that patients with a history of more frequent symptoms demonstrated greater improvements when treated with RG2417 than patients without a history of frequent symptoms. For example, patients with more than 5 episodes of depression over their entire life (n=50) demonstrated greater improvements in their symptoms of depression compared to patients with 5 or fewer lifetime episodes of depression. From weeks 2-6 of treatment, the patients with more than 5 lifetime episodes of depression who received RG2417 had an average improvement on MADRS of 5.5 points over place
'/>"/>

SOURCE Repligen Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Repligen Reports Positive Phase 2a Clinical Trial Results of RG2417 for Symptoms of Bipolar Disorder
2. Repligen Initiates Phase 3 Clinical Trial of RG1068 for Pancreatic MRI Imaging
3. Repligen Receives FDA Fast Track Designation for RG1068 for Pancreatic Imaging
4. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
5. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
6. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
7. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
8. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
9. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
10. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
11. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... -- CANTEL MEDICAL CORP. (NYSE: CMN ) will ... 2015 on Thursday, March 12 before the market opens, and ... AM ET. To participate in the conference ... the beginning of the call. If you are unable to ... from Thursday, March 12, 2015 through midnight on May 12, ...
(Date:3/5/2015)...  Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage ... chronic pain, today announced the appointment of several ... panel of experts will provide support for planning ... the company pipeline of novel investigational therapies to ... range of areas including opioid receptors, addiction, psychiatry, ...
(Date:3/5/2015)... 5, 2015 - Cross reference: ... http://www.epa.eu ) - Hitachi Medical Systems ... generazione di OASIS* all,ECR 2015. Si tratta di un ... da 1.2 T che migliora la capacità diagnostica dei ... al comfort del paziente. Le nuove funzionalità di OASIS ...
Breaking Medicine Technology:Cantel Medical Corp. To Hold Conference Call To Discuss Results For Its Second Quarter Ended January 31, 2015 2Relmada Therapeutics Names Leading Clinicians and Researchers in Pain Therapy Development to Advisory Roles 2Relmada Therapeutics Names Leading Clinicians and Researchers in Pain Therapy Development to Advisory Roles 3Relmada Therapeutics Names Leading Clinicians and Researchers in Pain Therapy Development to Advisory Roles 4Hitachi Medical Systems Europe lancia la nuova generazione di OASIS*: Il sistema di RM aperta ad alto campo da 1.2 T. Ancora più valore al paziente 2Hitachi Medical Systems Europe lancia la nuova generazione di OASIS*: Il sistema di RM aperta ad alto campo da 1.2 T. Ancora più valore al paziente 3Hitachi Medical Systems Europe lancia la nuova generazione di OASIS*: Il sistema di RM aperta ad alto campo da 1.2 T. Ancora più valore al paziente 4
... 2011 Watson Pharmaceuticals, Inc. (NYSE: WPI ), ... Watson,s President and Chief Executive Officer, will provide an overview ... Credit Suisse Health Care Conference on Wednesday, November 9, 2011 ... Biltmore Hotel in Phoenix. The presentation will be webcast live ...
... Oct. 28, 2011 Delcath Systems, Inc. (Nasdaq: ... and webcast to discuss its recent corporate developments and update ... ET.  Eamonn Hobbs, President and Chief Executive Officer will host ... conference call is 800-322-5044 for domestic participants and 617-614-4927 for ...
Cached Medicine Technology:Delcath Systems to Report Third Quarter Progress and Conduct Conference Call 2Delcath Systems to Report Third Quarter Progress and Conduct Conference Call 3
(Date:3/6/2015)... 2015 The Public Health Accreditation ... accreditation status to seven more health departments. This week’s ... million people can now be assured that their health ... health of their communities. , Public health departments play ... of people and communities. Across the nation, health departments ...
(Date:3/5/2015)... 2015 This week, 60 ... low-cost laminate flooring products, initiating widespread concern from ... building materials made primarily from bamboo, stands behind ... their flooring products for volatile organic compounds (VOCs) ... International (BMH). Results from formaldehyde emissions testing ...
(Date:3/5/2015)... Central Nebraska Imaging (CNI) is pleased ... brand’s new logo and optimized website. , ... approach to expert diagnostic imaging, centered on patient care. ... to be a resource for Nebraska patients and a ... communication and referral functionality, video content and resources to ...
(Date:3/5/2015)... March 05, 2015 SuperCloset has released a ... The series aims to teach viewers everything they need to ... Grow Like a SuperPro takes you from seed all the ... to clone, to how to prune Grow Like a SuperPro ... offering the whole series for download for a special introductory ...
(Date:3/5/2015)... Anaheim, Calif. (PRWEB) March 05, 2015 ... plant-powered beverages, today announced at Natural Products Expo West ... drinks are now 100 percent soy and dairy free. ... 10.5-ounce single serve bottle and are packed with six ... rice protein that includes fiber, B vitamins and magnesium. ...
Breaking Medicine News(10 mins):Health News:Nearly 113 Million U.S. Residents Now Reaping Benefits of National Public Health Department Accreditation 2Health News:Nearly 113 Million U.S. Residents Now Reaping Benefits of National Public Health Department Accreditation 3Health News:With Homeowners Concerned About Formaldehyde, Cali Bamboo Puts Safety Above Bottom Line 2Health News:Central Nebraska Imaging Center Gets Rebranding 2Health News:Califia Farms Vegan Protein and New Single Serve Almondmilks to Hit Supermarket Shelves this Month 2Health News:Califia Farms Vegan Protein and New Single Serve Almondmilks to Hit Supermarket Shelves this Month 3
... Older adults may be better able to comply ... out simple paper tables that track what they take ... use of a "medtable" may help to prevent medication-related ... Journal of Experimental Psychology: Applied, published ...
... Sept. 9 Governor Edward G.,Rendell today announced ... has,served as Secretary of the Pennsylvania Department of ... a passionate voice for protecting and improving,the health ... himself as an effective leader, addressing a variety ...
... in Past Year ... Display Ads, RESTON, Va., Sept. 9 comScore, Inc. ... results of a,study showing that the health information site category ... four times the growth rate of the,total U.S. Internet population., ...
... the most obese, new research finds , , TUESDAY, Sept. 9 ... you are to have a heart attack earlier in life, ... as people got progressively more obese, the rate at which ... Eric D. Peterson, a professor of medicine at Duke University ...
... Delta Dental funding pioneer studies to improve oral health for youngsters ... ... Mich., Sept. 9 The affiliated companies of,Delta Dental of Michigan, ... if sugarless lollipops containing,licorice extract can reduce the bacteria that causes ...
... Media Network on ... October 1, 2008, ... of the popular children,s program "The Wumblers" to its schedule,of digital ... programming, Health Media Network is a perfect,home for the cartoon series, ...
Cached Medicine News:Health News:Older adults can take medicines more safely and effectively by charting their daily routines 2Health News:Older adults can take medicines more safely and effectively by charting their daily routines 3Health News:Governor Rendell Announces Resignation of Health Secretary Dr. Calvin Johnson 2Health News:Online Health Information Category Grows at Rate Four Times Faster Than Total Internet 2Health News:Online Health Information Category Grows at Rate Four Times Faster Than Total Internet 3Health News:Online Health Information Category Grows at Rate Four Times Faster Than Total Internet 4Health News:Heavier People Have Heart Attacks Earlier 2Health News:Heavier People Have Heart Attacks Earlier 3Health News:How Many Licks Does it Take to Reduce Tooth Decay? 2Health News:How Many Licks Does it Take to Reduce Tooth Decay? 3Health News:How Many Licks Does it Take to Reduce Tooth Decay? 4Health News:Health Media Network Broadcasts 'The Wumblers' 2
... Matrix Perimeter utilizes Welch Allyn Frequency ... breakthrough in visual field testing by ... to characterize glaucoma and basic glaucoma ... Perimeter, the Matrix doubles as an ...
... complete solution. , Increased requirements for quality ... These are just some of the daily ... can impact the amount of time spent ... , You can't afford to waste ...
imEXPRESS uses the control panel and setup wizard concept (familiar to any Windows user) allowing you to quickly and easily connect and control your instruments....
This is a reduced form of the 100 Hue test and L'Anthony New Color Test. The 40 Hue test is obviously quicker to administer. It provides extensive chromatic sensitivity and gives a quantitative score...
Medicine Products: