Navigation Links
Renova Therapeutics enters into agreement to receive stresscopin investigational new drug file from Janssen
Date:2/6/2017

SAN DIEGO, Calif., Feb. 6, 2017 /PRNewswire-USNewswire/ -- Renova™ Therapeutics, Inc., a biotechnology company developing gene therapy treatments for congestive heart failure and type 2 diabetes, announced today that it has entered into an agreement with Janssen Pharmaceuticals, Inc., whereby the investigational new drug (IND) file for stresscopin – a hormone involved in responses to physiological stress – will be transferred from Janssen, where it was previously under development. Renova Therapeutics plans to advance development of the stresscopin program as RT-400, a peptide infusion treatment for episodes of Acute Decompensated Heart Failure (ADHF).

In the United States, ADHF accounts for approximately half of all heart failure-related causes of hospitalization.1 From 2005 to 2010, the average estimated number of ADHF hospitalizations in the U.S. was 1.76 million.2 Annual mortality following an ADHF hospitalization is about 30%.3

"Obtaining this stresscopin program IND helps propel forward the development of our peptide infusion product candidate, RT-400," said Jack W. Reich, Ph.D., CEO and Co-founder of Renova Therapeutics. "With this data, we hope to see promising results as we initiate pivotal trials."

In addition, Renova Therapeutics holds an exclusive license to the stresscopin peptide from the nonprofit Research Development Foundation.

About Acute Decompensated Heart Failure
Acute Decompensated Heart Failure (ADHF) is a severe episode of acute respiratory distress in which a heart failure patient experiences a sudden or gradual onset of the signs of heart failure that requires either initiation or escalation of treatment to relieve symptoms and prevent death. ADHF is caused by severe fluid congestion of the body's organs, especially the lungs, due to the failing heart providing inadequate circulation.

Symptoms of ADHF can include difficulty breathing, waking up from sleep gasping for air, fatigue, swelling of the legs or feet, as well as chest pain and pressure. Most episodes require immediate emergency room visits or hospitalizations for treatment.

Current treatment options for ADHF primarily involve reducing the organ fluid levels with diuretics, delivered intravenously, and stabilizing heart function with vasodilators such as nitroglycerin. Additional treatments can include providing breathing support using a face mask or breathing tube, as well as an ultrafiltration process to remove fluids in people with ADHF associated with kidney failure.

About Renova Therapeutics
Renova Therapeutics is developing definitive, one-time gene therapies and peptide infusion treatments to restore the health of people suffering from chronic diseases. The first indications the company is pursuing are gene therapy treatments for congestive heart failure (CHF) and type 2 diabetes, two of the most common and devastating chronic diseases in the world. The company's lead product, RT-100, is a treatment that delivers a therapeutic gene directly to the heart during a routine outpatient procedure and has the potential to increase heart function in millions of patients with CHF. The company's product pipeline also includes a groundbreaking gene therapy in preclinical stage for sufferers of type 2 diabetes, as well as a peptide infusion therapy for the treatment of acute decompensated heart failure. Renova Therapeutics was founded in 2009 and is led by an experienced management team in biopharmaceuticals and gene therapy. For additional information about the company, please visit www.renovatherapeutics.com.

References
1 Chang PP, Chambless LE, Shahar E, et al. Incidence and Survival of Hospitalized Acute Decompensated Heart Failure in Four US Communities (from the Atherosclerosis Risk in Communities Study). The American journal of cardiology. 2014;113(3):504-510. doi:10.1016/j.amjcard.2013.10.032.
2 Agarwal SK, Wruck L, Quibrera M, et al. Temporal Trends in Hospitalization for Acute Decompensated Heart Failure in the United States, 1998–201. Am. J. Epidemiol. 2016; 183(5):462-470.
3 Dhingra A, Garg A, Kaur S, et al. Epidemiology of heart failure with preserved ejection fraction. Curr Heart Fail Rep. 2014; 11(4):354–365.

 

To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/renova-therapeutics-enters-into-agreement-to-receive-stresscopin-investigational-new-drug-file-from-janssen-300402057.html


'/>"/>
SOURCE Renova Therapeutics
Copyright©2017 PR Newswire.
All rights reserved


Related medicine technology :

1. Renova Therapeutics receives additional NIH grant to continue paracrine gene therapy research for congestive heart failure
2. Lonza and Renova Therapeutics Announce Manufacturing Agreement for Clinical Supply of RT-100 Gene Therapy
3. CEO and Co-Founder of Renova Therapeutics receives Entrepreneur of the Year award from Washington & Jefferson College
4. Renova Therapeutics appoints Richard Mac McCloskey to head companys clinical development efforts
5. Renova Therapeutics expands robust gene therapy intellectual property portfolio for cardiovascular and metabolic disease treatments
6. Renova Therapeutics recruits seasoned expert to lead companys regulatory and quality efforts
7. ViveBio, LLC Enters Worldwide Exclusive Licensing Agreement with Renovar Inc. for Novel Urine Based Biomarker Technologies Covering Kidney Disease and Transplant Monitoring
8. Renova Therapeutics welcomes new board member, raises $7.52 million in Series C financing round
9. Entest BioMedical Inc.s Subsidiary Zander Therapeutics Makes Key Additions to Management Team as the Company Prepares to Move Forward in the $63 Billion Veterinary / Pet Market Niche
10. The Biotech Market Grows as Demand for New Therapeutics Increases
11. SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in TG Therapeutics, Inc. of Class Action Lawsuit and Upcoming Deadline - TGTX
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2017)... CAESAREA, Israel , May 4, 2017  DarioHealth ... with mobile health and big data solutions, today announced ... an A&D Company, and STI Technologies Limited to lower ... effective immediately. Through STI,s innoviCares card, which is available ... , DarioHealth customers will be eligible for additional ...
(Date:5/3/2017)... 2017  Kalorama Information notes that transplant diagnostics ... year and this is projected to continue to ... (HSCT) or bone marrow transplants require histocompatibility between ... for this task. This according to a new ... The various PCR-based methodologies, Sanger sequencing and NGS ...
(Date:5/2/2017)... 2017  George Clinical, a leading full-service CRO in ... Vector Oncology, a Memphis -based ... today that George Clinical has acquired Vector Oncology,s Pharma Services ... dual purpose of strengthening the ability of George ... solutions throughout the Asia-Pacific , ...
Breaking Medicine Technology:
(Date:5/21/2017)... ... 2017 , ... Pot. Reefer. Grass. Mary Jane. No matter what people call ... like never before. More than a map, new social marketplace Weedable goes ... – and for the first time – each other. A social marketplace like no ...
(Date:5/21/2017)... ... ... Following the tragic and widely publicized death of Rory Staunton, 12, from ... follow a protocol to quickly identify and treat the condition. , The mandate ... have saved Rory or anyone else’s life. , Now, five years after the ...
(Date:5/19/2017)... ... May 19, 2017 , ... DMG Productions is ... of Innovations with Ed Begley, Jr., airing fourth quarter 2017 on FOX Business. ... clean, organic dietary supplement made from naturally occurring ingredients. Innovations will enlighten viewers ...
(Date:5/19/2017)... , ... May 19, 2017 , ... ... services and retirement planning assistance to families and business owners in the region, ... to advocate for MS sufferers and their families. , Multiple sclerosis (MS) is ...
(Date:5/19/2017)... ... May 18, 2017 , ... ML Billing, 2016 Billing Company of the ... specializes in large group practices, is pleased to announce their 30th anniversary. Not only ... the standard in all aspects of full-service medical billing. This has allowed ML Billing ...
Breaking Medicine News(10 mins):