Navigation Links
Relmada Therapeutics Announces LevoCap ER Development Progress
Date:3/4/2013

BLUE BELL, Pa., March 4, 2013 /PRNewswire/ -- Relmada Therapeutics, Inc., a clinical-stage company developing novel therapies for the treatment of chronic pain, today announced the approval of the application of a Clinical Trial Authorization (CTA) that was submitted with the Medicine and Health Regulatory Agency (MHRA) to conduct a Phase I pharmacokinetic study with the development product abuse-deterrent LevoCap extended release (ER) capsules.  The MHRA is the UK government agency which is responsible for ensuring that medicines and medical devices work and are acceptably safe.

This Phase I safety study is designed to assess the bioavailability and dose proportionality of three levorphanol extended release (ER) formulations, how these compare with a marketed IR (immediate release) product available in the US, and whether there are any differences under fed and fasted conditions.

"This significant progress is in line with the development plan of LevoCap ER. If this study shows positive results, then we will be on track to enter the phase III program in the fourth quarter," said Sergio Traversa , CEO of Relmada.

LevoCap ER, Relmada's lead product is intended to add a powerful new tool to treat pain where opioids alone or non-opioids alone do not provide adequate relief.  Unlike other opioids, levorphanol, the active ingredient in LevoCap ER modulates pain through both opioid pathways and noradrenergic pathways thereby providing pain relief through multiple mechanisms in one capsule. Levorphanol has also been shown to partially reverse analgesic tolerance to morphine and may therefore benefit patients who are tolerant to the analgesic effects of their current opioid. 

Based on its pharmacological profile, LevoCap alone should demonstrate improved efficacy in a broader patient population compared to other opioids.  This includes the vast category of patients affected by chronic pain with combined nociceptive and neuropathic components, which frequently require treatment with two or more pain medications to achieve efficacy. 

About Relmada Therapeutics

Relmada Therapeutics, Inc. is a clinical stage, private biopharmaceutical company focused on developing both novel versions of proven drugs and new molecules that potentially address high unmet medical needs in the treatment of chronic pain.  The Company has a deep and diversified portfolio of four lead products at different stages of development and an early stage pipeline of an additional three products. 

For more information, contact:

Visit our website at www.relmada.com



'/>"/>
SOURCE Relmada Therapeutics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Related medicine technology :

1. Acquired Orphan Blood Diseases Therapeutics Market to 2019 - Search for Disease Modifying Drugs Central to Unlocking Premium Pricing Potential
2. Autoinjectors to 2018 - Devices, Therapeutics, Markets, Strategies and Prospects
3. Nektar Therapeutics to Present at the 33rd Annual Cowen and Company Healthcare Conference in Boston
4. ADVENTRX Announces Corporate Name Change To "Mast Therapeutics, Inc."; Ticker Symbol Change To "MSTX"
5. Nektar Therapeutics Reports Fourth Quarter and Year-End 2012 Financial Results
6. Orexigen Therapeutics Announces Webcast of Upcoming Presentation at the Cowen & Co. Annual Health Care Conference
7. Takeda and Resolve Therapeutics Enter Autoimmune Partnership
8. Frost & Sullivan Recognizes KAERs Game-Changing Innovating Aerosol Drug Delivery Methods for High-Dose Respiratory Disease Therapeutics
9. United Therapeutics Corporation Reports 2012 Fourth Quarter and Annual Financial Results
10. iBio And Caliber Biotherapeutics Establish License And Collaboration Relationship
11. Elcelyx Therapeutics Completes $20 Million Series C Financing to Advance NewMet and Lovidia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... Quebec , Dec. 8, 2016  Valeant ... and TSX: VRX) ("Valeant") today announced positive results ... clinical study to assess the safety and efficacy ... the treatment of plaque psoriasis. ... subjects with moderate to severe psoriasis, IDP-118 showed ...
(Date:12/8/2016)... CAMBRIDGE, Mass. , Dec. 8, 2016 /PRNewswire/ ... that it has obtained proof-of-mechanism for neflamapimod (previously ... recently completed Phase 2a clinical trials that demonstrated ... from Study 302 (12-week treatment) and Study 303 ... the Clinical Trials in Alzheimer,s Disease (CTAD) scientific ...
(Date:12/8/2016)... -- A Small Business Innovative Research (SBIR) grant has ... to Phoenix -based NeuroEM Therapeutics, Inc. ... will seek to determine an optimal set of treatment ... to treat Alzheimer,s Disease. The grant will also investigate ... other neurologic disorders such as Parkinson,s Disease and PTSD. ...
Breaking Medicine Technology:
(Date:12/8/2016)... ... ... California Senate Bill (SB) 863, signed into law in 2012, may have contributed ... to CompScope™ Medical Benchmarks for California, 17th Edition , a study by the ... per claim in California decreased 4 percent in 2013 and then 3 percent in ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... services from offices headquartered in Little Rock, has initiated a charity drive to ... the National Foundation to End Senior Hunger, Arkansas ranks first in senior hunger ...
(Date:12/8/2016)... ... December 08, 2016 , ... Coppin Insurance Agency, an insurance and ... and around the Cape Coral area, is embarking on a charity drive with the ... Florida. , The Harry Chapin Food Bank of Southwest Florida works to provide fresh ...
(Date:12/7/2016)... ... December 07, 2016 , ... DrugDev again ... that it is one of the early adopters completing EU-U.S. Privacy Shield Certification from ... to provide companies on both sides of the Atlantic with a mechanism to comply ...
(Date:12/7/2016)... ... December 07, 2016 , ... Children ... bodies, a researcher at the Icahn School of Medicine at Mount Sinai has ... found that when young children are exposed to secondhand marijuana smoke, measurable amounts ...
Breaking Medicine News(10 mins):