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Regulus Therapeutics Forms Strategic Alliance for Discovery, Development and Commercialization of microRNA Therapeutics with AstraZeneca
Date:8/14/2012

LA JOLLA, Calif., Aug. 14, 2012 /PRNewswire/ -- Regulus Therapeutics Inc., a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today that it has entered into a strategic alliance with AstraZeneca to discover, develop, and commercialize microRNA therapeutics for three exclusive targets which are currently in pre-clinical development. These targets are focused on cardiovascular and metabolic diseases and oncology.  

Under the terms of the agreement, AstraZeneca will make a $28M payment which includes an equity investment and an upfront payment to Regulus. 

Regulus and AstraZeneca will collaborate on three microRNA targets, which include Regulus' lead cardiovascular/metabolic disease program targeting microRNA-33 for the treatment of atherosclerosis.

Regulus will lead preclinical development and, if successful, could receive pre-clinical milestone payments.  AstraZeneca will lead and fund the clinical development and commercialization of these programs.

In addition, Regulus could also receive clinical milestones based on the successful development of microRNA therapies in each target area. Regulus is also eligible to receive significant launch and commercial milestone payments and royalties contingent on the successful commercialization of microRNA therapeutic products by AstraZeneca.

Gunnar Olsson, Vice President and Head of AstraZeneca's Cardiovascular & Gastrointestinal Innovative Medicines Unit, said: "MicroRNA therapeutics have the potential to open up innovative and important treatment options for patients and AstraZeneca is pleased to collaborate with Regulus in this new and exciting area. Through this collaboration we will marry Regulus' expertise in the microRNA field with our own internal drug development experience with the goal of bringing new treatment options to patients with atherosclerosis-related disease, metabolic disturbance
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SOURCE Regulus Therapeutics Inc.
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