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Regulus Reports Third Quarter 2013 Financial Results and Recent Highlights
Date:11/13/2013

Option Agreement with Sanofi. At the ASN Kidney Week 2013 meeting, Regulus and its strategic alliance partner, Sanofi, and its collaborator at the University of Washington, presented positive preclinical data in a poster and oral presentations demonstrating that miR-21 plays an important role in the disease progression of Alport Syndrome in collagen 4A3 deficient mice. According to the National Institutes of Health, Alport Syndrome occurs in approximately 1 in 50,000 newborns. Alport Syndrome is a genetic condition characterized by kidney disease, hearing loss, and eye abnormalities. The kidneys become less able to function as this condition progresses, resulting in end-stage renal disease. These results demonstrate that treatment with an anti-miR-21 candidate significantly improved renal function, significantly reversed regulated genes and pathways associated with renal pathology, and increased the lifespan of the mice by 20 percent.
Regulus and Sanofi entered into an Option Agreement to enable exclusive negotiation of a potential new co-development and commercialization agreement. Under the terms of the Option Agreement, Regulus has the exclusive right to negotiate with Sanofi to enter into a co-development and commercialization agreement for certain miR-21 anti-miRs in oncology and in Alport Syndrome. Regulus anticipates that the second microRNA candidate to be nominated for clinical development by the end of the year under its 'Road to the Clinic' strategy may come from the miR-21 fibrosis program.
  • Achieved Significant Progress in Strategic Alliance with AstraZeneca; New Pre-Clinically Validated microRNA Oncology Target Selected. Under Regulus' strategic alliance to discover, develop, and commercialize microRNA therapeutics with AstraZeneca, an undisclosed, pre-clinically validated oncology target was selected by AstraZeneca. The companies continue to collaborate on three exclusive microRNA targets in cardiovascular and metabolic
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  • SOURCE Regulus Therapeutics Inc.
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    1. Regulus Presents Positive Preclinical Data Demonstrating that microRNA-21 Plays an Important Role in Alport Syndrome
    2. Regulus Announces Timing for Third Quarter 2013 Financial Results Webcast and Conference Call
    3. Regulus Announces Significant Progress in Strategic Alliance with AstraZeneca and Selection of a New Pre-Clinically Validated microRNA Oncology Target
    4. Regulus Reports Second Quarter 2013 Financial Results and Recent Highlights
    5. Regulus Announces Timing for Second Quarter 2013 Financial Results Webcast and Conference Call
    6. Regulus Names Stelios Papadopoulos, Ph.D. as Chairman of its Board of Directors
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    8. Regulus Provides Update on Road to the Clinic Strategy and Reports First Quarter 2013 Financial Results and Recent Highlights
    9. Regulus Announces Timing for First Quarter 2013 Financial Results Webcast and Conference Call
    10. Regulus Appoints William H. Rastetter, Ph.D. to its Board of Directors
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