Navigation Links
Regulus Presents Positive Preclinical Data Demonstrating that microRNA-21 Plays an Important Role in Alport Syndrome
Date:11/8/2013

ser toward the selection of an anti-miR-21 clinical development candidate and we remain excited about the potential to bring this innovative treatment to patients with this devastating disease." 

Additionally, microRNA therapeutics will be discussed in two oral presentations at the meeting:

  • On Friday, November 8, 2013 at 2:00 p.m. EST, Jeremy Duffield M.D., Ph.D., Regulus' collaborator at the University of Washington, will give an oral presentation titled "MicroRNAs Are Novel Therapeutic Targets to Treat Kidney Injury and Fibrosis"; and  
  • On Saturday, November 9, 2013 at 5:42 p.m. EST, Regulus scientists and representatives from its collaborator at the University of Washington will give an oral presentation titled "Anti-miR21 Protects Collagen 4A3 Deficient Mice from Progression of Alport Disease by Decreasing Oxidative Stress"

About miR-21 and Alport Syndrome

According to the National Institutes of Health, Alport Syndrome occurs in approximately 1 in 50,000 newborns.  Alport syndrome is a genetic condition characterized by kidney disease, hearing loss, and eye abnormalities.  The kidneys become less able to function as this condition progresses, resulting in end-stage renal disease (ESRD).

Mutations in the COL4A3, COL4A4, and COL4A5 genes cause Alport Syndrome. These genes provide instructions for making one component of a protein called type IV collagen. This protein plays an important role in the kidneys, specifically in structures called glomeruli. Glomeruli are clusters of specialized blood vessels that remove water and waste products from blood and create urine. Mutations in these genes result in abnormalities of the type IV collagen in glomeruli, which prevents the kidneys from properly filtering the blood and allows blood and protein to pass into the urine.

miR-21 is a 2
'/>"/>

SOURCE Regulus Therapeutics Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Regulus Announces Timing for Third Quarter 2013 Financial Results Webcast and Conference Call
2. Regulus Announces Significant Progress in Strategic Alliance with AstraZeneca and Selection of a New Pre-Clinically Validated microRNA Oncology Target
3. Regulus Reports Second Quarter 2013 Financial Results and Recent Highlights
4. Regulus Announces Timing for Second Quarter 2013 Financial Results Webcast and Conference Call
5. Regulus Names Stelios Papadopoulos, Ph.D. as Chairman of its Board of Directors
6. Regulus to Present at Deutsche Bank 38th Annual Healthcare Conference
7. Regulus Provides Update on Road to the Clinic Strategy and Reports First Quarter 2013 Financial Results and Recent Highlights
8. Regulus Announces Timing for First Quarter 2013 Financial Results Webcast and Conference Call
9. Regulus Appoints William H. Rastetter, Ph.D. to its Board of Directors
10. Regulus to Present at Future Leaders in the Biotech Industry Conference
11. Regulus to Present at Cowen and Company 33rd Annual Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... MADRID , June 2, 2015 ... annuale della American Society of Clinical Oncology    ... di fase 3 SAR3007, resi noti dal dipartimento Ricerca ... evidenziato un significativo miglioramento della sopravvivenza libera da progressione ... rispetto al trattamento con dacarbazina in pazienti con liposarcoma ...
(Date:6/1/2015)... , June 1, 2015  LaunchPad Medical, ... a definitive agreement to license Stryker Corporation,s (NYSE: ... based on a unique synthetic biomaterial.  Under the ... exclusive worldwide license from Stryker for this technology ... pending U.S. patents and includes data from multiple ...
(Date:6/1/2015)... , June 1, 2015  Research Solutions, Inc. (OTCQB: ... and medical (STM) information for life science companies, academic ... to present at the LD Micro Invitational being held ... in Los Angeles . ... on Wednesday, June 3rd at 9:30 a.m. Pacific time, ...
Breaking Medicine Technology:PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 2PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 3PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 4PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 5PharmaMar annuncia che lo studio di Janssen ha evidenziato che la trabectedina migliora il controllo della malattia in pazienti con sarcoma dei tessuti molli in stato avanzato 6LaunchPad Medical Executes Definitive License Agreement with Stryker for Novel Bone Adhesive Technology 2Research Solutions to Present at the LD Micro Invitational on June 3, 2015 2Research Solutions to Present at the LD Micro Invitational on June 3, 2015 3
... LLC has launched a full line of non-prescription, topical ... relief of nerve pain caused by diabetes, post-shingles, chemotherapy, ... the only full line of skin care and pain ... developed from the ground up in oils, lotions and ...
... cites in its newly published " Medical Imaging ... medical imaging equipment exceeded $21 billion in ... Medical imaging can ... computed tomography (CT), positron emission tomography (PET), single ...
Cached Medicine Technology:Affordable Nerve Pain Treatment Now Available in the U.S. 2Global Spending on Medical Imaging Equipment Exceeded $21 Billion in 2010 2Global Spending on Medical Imaging Equipment Exceeded $21 Billion in 2010 3
(Date:6/2/2015)... TheCelebrityDresses.com, a popular online store selling ... their summer fashion cocktail dresses. The company carries more ... would be suitable for a wide variety of summer ... designs and make high quality trendy special occasion ... high quality satin, chiffon and cotton. Their products feature ...
(Date:6/2/2015)... 2015 First Choice Emergency Room ... in the United States, named Kenneth Alan Totz, D.O.as ... Road facility. , “We are pleased to announce ... facility,” said Dr. James M. Muzzarelli, Executive Medical Director ... received his undergraduate degree from St. Edwards University in ...
(Date:6/2/2015)... Thermi, formerly ThermiAesthetics, a fast ... transitioned into its new company headquarters in Irving, ... continued rapid worldwide expansion and houses the corporate ... Thermi employees, including those of the warehousing, shipping ... one of the fastest growing aesthetic companies in ...
(Date:6/2/2015)... Join us for a new event in Westwood, ... Rhonda Martin , who overcame her brain aneurysm during the ... to raising awareness and funds for brain aneurysm research. ... that there will be one less case of someone suffering ... to join the 1st Anniversary Awareness Walk in Honor ...
(Date:6/1/2015)... City, NY (PRWEB) June 02, 2015 ... honors Miriam Wirski as a 2015-2016 inductee ... is recognized with this prestigious distinction for leadership in ... for professional women, boasting more than 700,000 members and ... present Miriam with this prestigious honor,” said NAPW President ...
Breaking Medicine News(10 mins):Health News:First Choice Emergency Room Announces Dr. Kenneth Alan Totz as New Medical Director of Houston – Jones Road Facility 2Health News:Thermi Moves to New Corporate Headquarters as Rapid Company Expansion Continues 2Health News:New Awareness Raising Event in Westwood, NJ to Benefit Renowned Brain Aneurysm Foundation 2Health News:National Association of Professional Women Inducts Miriam Wirski, Holistic Life Coach, Into its VIP Woman of the Year Circle 2
... a region of a human chromosome that is associated ... People with EoE frequently have difficulty eating or may ... further suggests that a suspected so-called master allergy gene ... rare but debilitating disorder. EoE is characterized ...
... between stress and death risk, researchers say , SUNDAY, March ... misery and death has helped researchers identify a gene variant ... U.S. research team focused on a gene called IL6, which ... to cardiovascular disease, neurodegeneration and some types of cancer. , ...
... ... , ... 2010 -- On Saturday, March 6 Yvonne’s Day Spa opened at Market Square at Potomac ... known in the Middle East and Asia as “doctor fish”, are minnow-like and toothless, and ...
... ... ... ... ...
... Louis, MO - Breast cancer patients with early stage disease ... benefit from radiation after mastectomy, because of the low present-day ... finding that could one day change the course of treatment ... at The University of Texas M. D. Anderson Cancer. ...
... ... Abelson says proposed curbs address an illusion instead of the real problem — doctors ... ... injury lawyer in Maryland and Washington, DC, says proposed limits on damage awards in ...
Cached Medicine News:Health News:NIAID media availability: Food allergy-related disorder linked to master allergy gene 2Health News:Gene Variant May Help Some Overcome Adversity 2Health News:Nibble Fish Arrive in Arlington Just in Time for Beautiful Toes for Oscar Night 2Health News:The Pentagon Tragedy: Mental Illness, Violence and What Reporters Should Ask 2Health News:The Pentagon Tragedy: Mental Illness, Violence and What Reporters Should Ask 3Health News:The Pentagon Tragedy: Mental Illness, Violence and What Reporters Should Ask 4Health News:The Pentagon Tragedy: Mental Illness, Violence and What Reporters Should Ask 5Health News:Most early-stage breast cancer patients may not need radiation after mastectomy 2Health News:Most early-stage breast cancer patients may not need radiation after mastectomy 3Health News:Congressional Concession On Medical Malpractice Awards Will Not Lower Health Care Costs And Will Hurt Patients' Rights, Washington, DC Attorney Says 2Health News:Congressional Concession On Medical Malpractice Awards Will Not Lower Health Care Costs And Will Hurt Patients' Rights, Washington, DC Attorney Says 3
...
...
...
Open blade speculum designed for both temporal and superior approach ocular surgery. Thumb screw adjusting mechanism. Manufactured in titanium....
Medicine Products: