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Regulus Announces Significant Progress in Strategic Alliance with AstraZeneca and Selection of a New Pre-Clinically Validated microRNA Oncology Target
Date:10/28/2013

LA JOLLA, Calif., Oct. 28, 2013 /PRNewswire/ -- Regulus Therapeutics Inc. (NASDAQ: RGLS), a biopharmaceutical company leading the discovery and development of innovative medicines targeting microRNAs, announced today the selection of an undisclosed oncology target by AstraZeneca under the strategic alliance to discover, develop, and commercialize microRNA therapeutics.  Regulus and AstraZeneca continue to collaborate on three exclusive microRNA targets in cardiovascular and metabolic diseases and oncology.

"We are very pleased with the successful relationship we have built with AstraZeneca and their selection of a validated microRNA target for oncology indications," said Neil W. Gibson, Ph.D., Chief Scientific Officer of Regulus.  "In the last year, we have made significant progress in advancing our drug discovery efforts against the portfolio of AstraZeneca targets.  With the support of AstraZeneca's drug development expertise and commitment to the RNA therapeutics field, we continue to harness our microRNA expertise to develop innovative, first-in-class treatment options for patients in need." 

In August 2012, Regulus and AstraZeneca formed a strategic alliance focused on three exclusive microRNA targets for cardiovascular and metabolic diseases and oncology, which includes Regulus' program targeting microRNA-33 for the treatment of atherosclerosis.  Under the terms of the alliance, Regulus will lead preclinical development and, if successful, could receive preclinical milestone payments.  AstraZeneca will lead and fund the clinical development and commercialization of these programs.  In addition, Regulus could also receive clinical milestones based on the successful development of microRNA therapies in each target area. Regulus is also eligible to receive significant launch
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SOURCE Regulus Therapeutics Inc.
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