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Regeneron to Webcast Investor Briefing on VEGF Trap-Eye Clinical Program on Sunday, February 13th at 9 am ET
Date:2/9/2011

able differences in non-ocular adverse events among the study arms.

Trials in other indications such as CRVO and DME are currently underway or in preparation.

About Wet Age-Related Macular Degeneration (wet AMD)Age-related macular degeneration (AMD) is a leading cause of acquired blindness.  Macular degeneration is diagnosed as either dry (non-exudative) or wet (exudative).  In wet AMD, new blood vessels grow beneath the retina and leak blood and fluid.  This leakage causes disruption and dysfunction of the retina creating distortion and/or blind spots in central vision, and it can account for blindness in wet AMD patients.  Wet AMD is the leading cause of blindness for people over the age of 65 in the U.S. and Europe.  It is estimated that more than 210,000 Americans are newly diagnosed with and treated for wet AMD each year.

About Central Retinal Vein Occlusion (CRVO)Over 100,000 people in the United States and more than 66,000 people in key European countries are estimated to suffer from central retinal vein occlusion (CRVO).  CRVO is caused by obstruction of the central retinal vein that leads to a back up of blood and fluid in the retina.  This causes retinal injury and loss of vision.  The retina can also become "ischemic" (starved for oxygen), resulting in the growth of new, inappropriate blood vessels that can cause further vision loss and more serious complications.  Release of vascular endothelial growth factor (VEGF) contributes to increased vascular permeability in the eye and inappropriate new vessel growth.  It is believed that anti-VEGF treatment may help decrease vascular permeability and edema and prevent the inappropriate growth of new blood vessels in the retina in patients with CRVO.

About Diabetic Macular Edema (DME)Diabetic macular edema (DME) is the most prevalent cause of moderate vision loss in patients with diabetes.  DME is a common complica
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SOURCE Regeneron Pharmaceuticals, Inc.
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Related medicine technology :

1. Regeneron Announces Presentation at the ISI Annual Conference
2. Regeneron and Bayer Report Positive Results for VEGF Trap-Eye in Phase 3 Study in Central Retinal Vein Occlusion (CRVO) and in Phase 2 Study in Diabetic Macular Edema (DME)
3. Regeneron Schedules December 20, 2010 Teleconference and Webcast to Discuss Results of VEGF Trap-Eye Phase 3 Study in Central Retinal Vein Occlusion (CRVO) and Phase 2 Study in Diabetic Macular Edema (DME)
4. Christine A. Poon Elected to Regeneron Board of Directors
5. Regeneron Announces Presentation at the 2010 Credit Suisse Annual Healthcare Conference
6. Regeneron Announces Presentation at the 17th Annual NewsMakers in the Biotech Industry Conference
7. Regeneron Announces Exercise of Over-Allotment Option and Closing of Underwritten Offering of Common Stock
8. Regeneron Increases Size of Public Offering of Common Stock
9. Regeneron Pharmaceuticals, Inc. Announces The Sale of 4,500,000 Shares of Common Stock
10. Regeneron Announces Panel Discussion at Citis 5th Annual Biotech Day
11. Regeneron Announces Presentation at the UBS Global Life Sciences Conference
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