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Regeneron Reports Third Quarter 2009 Financial and Operating Results
Date:11/3/2009

.9 Recognition of revenue related to VelociGene((R)) agreement 0.7 0.5 2.2 0.5 --- --- --- --- Total antibody 59.0 32.6 149.9 80.8 ---- ---- ----- ---- Total sanofi-aventis contract research & development revenue $68.5 $42.0 $178.9 $116.3 ===== ===== ====== ======

Sanofi-aventis' reimbursement of Regeneron's aflibercept expenses decreased for the three and nine months ended September 30, 2009, compared to the same periods in 2008, primarily due to lower Company costs associated with internal research activities and, for the nine months ended September 30, 2009, lower costs related to manufacturing clinical drug supplies. Sanofi-aventis also incurs aflibercept development expenses directly, including costs related to the Phase 3 clinical trials sanofi-aventis is overseeing in the oncology program.

Sanofi-aventis' reimbursement of Regeneron's expenses under the antibody collaboration increased for the three and nine months ended September 30, 2009, compared to the same periods in 2008, due to an increase in research activities conducted under the collaboration's discovery agreement and increases in development activities for antibody candidates, including REGN88, REGN421, and REGN475, under the collaboration's license agreement.

For the three and nine months ended September 30, 2009 and 2008, contract research and development revenue from Bayer HealthCare consisted of the following:

                                   Three months ended   Nine months ended
                                      September 30,       September 30,
                                   ------------------  -----------------
    (In millions)          
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SOURCE Regeneron Pharmaceuticals, Inc.
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