Navigation Links
Regeneron Announces FDA Approval of EYLEA™ (aflibercept) Injection for the Treatment of Wet Age-Related Macular Degeneration
Date:11/18/2011

ts in EYLEA.

The recommended dose for EYLEA is 2 mg administered by intravitreal injection every four weeks (monthly) for the first 12 weeks (3 months), followed by 2 mg once every eight weeks (2 months).  Although EYLEA may be dosed as frequently as 2 mg every four weeks (monthly), additional efficacy was not demonstrated when EYLEA was dosed every four weeks compared to every eight weeks.

There is a potential risk of arterial thromboembolic events (ATEs) following use of intravitreal VEGF inhibitors, including EYLEA, defined as nonfatal stroke, nonfatal myocardial infarction, or vascular death (including deaths of unknown cause).  The incidence of ATEs with EYLEA in clinical trials was low (1.8%).

Serious adverse reactions related to the injection procedure have occurred in less than 0.1% of intravitreal injections with EYLEA and include endophthalmitis, traumatic cataract, and increased intraocular pressure.

About the VIEW 1 and VIEW 2 Clinical StudiesThe safety and efficacy of EYLEA were assessed in two randomized, multi-center, double-masked, active-controlled studies in patients with wet AMD.  A total of 2412 patients were treated and evaluable for efficacy (1817 with EYLEA) in the two studies (VIEW 1 and VIEW 2). In each study, patients were randomly assigned in a 1:1:1:1 ratio to one of four dosing regimens: 1) EYLEA administered 2 mg every eight weeks following three initial monthly doses (EYLEA 2Q8); 2) EYLEA administered 2 mg every four weeks (EYLEA 2Q4); 3) EYLEA 0.5 mg administered every four weeks (EYLEA 0.5Q4); and 4) ranibizumab administered 0.5 mg every four weeks (ranibizumab 0.5Q4).  Patient ages ranged from 49 to 99 years with a mean of 76 years.

In both studies, the primary efficacy endpoint was the proportion of patients who maintained vision, defined as losing fewer than 15 letters of visual acuity at week 52 compared to baseline.  Data are available through week 52.
'/>"/>

SOURCE Regeneron Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Sanofi and Regeneron Report Positive Preliminary Phase 2 Program Results for Anti-PCSK9 Antibody in Hypercholesterolemia
2. Regeneron Pharmaceuticals Announces Pricing of Offering of Convertible Senior Notes due October 1, 2016
3. Regeneron Ranked by Science Magazine as the #2 Employer in the Global Biopharmaceutical Industry
4. Regeneron Announces Clinical Presentations at ASRS 2011 Annual Meeting
5. Regeneron Reports Second Quarter 2011 Financial and Operating Results
6. Sanofi and Regeneron Report Positive Phase 2b Trial Results with Sarilumab in Rheumatoid Arthritis
7. Trading in Regeneron Common Stock Halted
8. Regeneron Reports First Quarter 2011 Financial and Operating Results
9. Regeneron Announces Presentation at the Bank of America Merrill Lynch 2011 Health Care Conference
10. Regeneron and Bayer Report Positive Results for VEGF Trap-Eye in Second Phase 3 Study in Central Retinal Vein Occlusion
11. Regeneron and Bayer Announce Start of Phase 3 Clinical Program in Diabetic Macular Edema
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... , July 7, 2015   ICD-10 Charts ... months of development, it has officially launched its ... Charts Training Academy and the new 4 Step ... well as all other ICD-10 Charts resources and ... in America, completely free-of-charge.  With the release of ...
(Date:7/7/2015)... 2015 Research and ... the "Elemental Analysis Market by Type (Organic, ... Application (Life Sciences, Food and Beverage Testing, Environment ... report to their offering. The ... types, technologies, and applications. By type, the market ...
(Date:7/7/2015)... and FREMONT, Calif. , July 7, ... South Korea and Velos, Inc. have entered into ... eResearch for cancer research nationally throughout South Korea ... The recent agreement signing was accompanied by a two day ... , South Korea.  National Cancer Center President ...
Breaking Medicine Technology:ICD-10 Charts Releases Revolutionary Free Solution for Complete ICD-10 Preparation 2ICD-10 Charts Releases Revolutionary Free Solution for Complete ICD-10 Preparation 3ICD-10 Charts Releases Revolutionary Free Solution for Complete ICD-10 Preparation 4Elemental Analysis (Organic, Inorganic) Market 2015 - Analysis & Global Forecasts to 2020 2National Cancer Center of South Korea and Velos Sign Long-Term Velos eResearch Agreement 2National Cancer Center of South Korea and Velos Sign Long-Term Velos eResearch Agreement 3
... Oct. 6 According to Millennium Research Group ... intelligence, growth in the $2 billion US cardiac ... the expanded approval of Boston Scientific,s chronic resynchronization ... I and II patients. The New ...
... Oct. 6 e-MDs, an industry leader in ... (EHRs) and practice management (PM) solutions,  congratulates  the ... Family Medicine of Fort Collins, CO, for their ... of Excellence recipients.  The Healthcare Information and Management ...
Cached Medicine Technology:Positive Results From the MADIT-CRT Trial Support the Expanding Approval of Cardiac Resynchronization Therapy Defibrillators 2Positive Results From the MADIT-CRT Trial Support the Expanding Approval of Cardiac Resynchronization Therapy Defibrillators 3e-MDs Clients Win HIMSS Davies Awards of Excellence 2e-MDs Clients Win HIMSS Davies Awards of Excellence 3e-MDs Clients Win HIMSS Davies Awards of Excellence 4
(Date:7/7/2015)... ... July 07, 2015 , ... Silverado today issues its first update on ... Summer 2015 on a four-acre site in Bellingham, Washington. Cordata Design Review Board approved ... officials and other members of the local community. , The new complex – located ...
(Date:7/7/2015)... ... 07, 2015 , ... Owners of Green Ladies Cleaning are very pleased to ... category. This honor can only be gained by votes from Madison Magazine readership. , ... products and methods they use daily. Having a home cleaned with all-natural products means ...
(Date:7/7/2015)... ... ... reputable source of authentic tickets for the 2015 CONCACAF Gold Cup Group A matches featuring ... , The 2015 CONCACAF Gold Cup is now upon us as Group A kicks ... will kick off in Frisco, CA from the Toyota Stadium and will feature two exciting ...
(Date:7/7/2015)... MA (PRWEB) , ... July 07, 2015 , ... The ... AIDS Action Committee of Massachusetts , and the Multicultural AIDS Coalition ... and other men who have sex with men (MSM) and transgender women, the ...
(Date:7/7/2015)... ... July 07, 2015 , ... Illinois cannabis ... is limited to permit holders. The Medical Cannabis Alliance of Illinois’ (MCAI) board ... forward and are committed to making sure patients have access to cannabis as ...
Breaking Medicine News(10 mins):Health News:New Silverado Memory Care Community Receives Unanimous Approval from Design Review Board 2Health News:Environmentally-Friendly House Cleaning Company Wins Best of Madison Magazine Award 2Health News:Panama vs Haiti & USA vs Honduras CONCACAF Group A Tickets at Toyota Stadium: Ticket Down Slashes Ticket Prices for Haiti vs Panama & USA vs Honduras in Frisco/Dallas 2Health News:Panama vs Haiti & USA vs Honduras CONCACAF Group A Tickets at Toyota Stadium: Ticket Down Slashes Ticket Prices for Haiti vs Panama & USA vs Honduras in Frisco/Dallas 3Health News:CDC Awards Fenway Health, AIDS Action, Multicultural AIDS Coalition $3.78m For ‘Getting To Zero’ HIV Prevention Partnership 2Health News:CDC Awards Fenway Health, AIDS Action, Multicultural AIDS Coalition $3.78m For ‘Getting To Zero’ HIV Prevention Partnership 3Health News:Cannabis Growers and Dispensaries Form Medical Cannabis Alliance of Illinois 2
... PHILADELPHIA, Feb. 27 New Jersey Senate Majority Leader Stephen ... scheduled to join Labor Leaders Charles Wowkanech , President of ... Atlantic-Cape May Counties Central Labor Council and Henry Nichola s, ... Employees at rallies in Deptford and Hammonton, N. J., in ...
... A-dec 300 Integrated System Contributes to a Healthier, ... 300 allows unprecedented integration of technology and is ... The new A-dec 300 system offers customers a ... the A-dec 500(R), yet maintains the high performance, ...
... Today ReportHARRISBURG, Pa., Feb. 27 The Department of ... of air pollutants or metals after extensively examining air ... acting Secretary John Hanger said that the results of ... in December 2008 that relied only on a ...
... Feb. 27 Dean Farms in New Castle, Lawrence ... and resumed sales of raw milk on Feb. 26, ... milk that has not been pasteurized. Pennsylvania farms selling ... their milk laboratory tested due to the health risks ...
... National Hospice and Palliative Care Organization released the ... Payment Advisory Commission,s (MedPAC) March report to Congress. ... hospice benefit.Each year, more than 1.4 million patients ... hospice benefit is responsible for millions of people ...
... findings from the nation,s largest study of diabetes in ... rise among every racial and ethnic group studied. Five ... Care provide a comprehensive picture of diabetes in ... in the United States, including non-Hispanic whites, Hispanics, blacks, ...
Cached Medicine News:Health News:Politicians and Labor Leaders Set to Lead Rallies Saturday (February 28) for Striking Innova Nurses 2Health News:New A-dec 300(TM) Offers Dentists an Innovative Equipment Solution 2Health News:PA DEP Finds Air Quality Around Schools to be Safe 2Health News:PA DEP Finds Air Quality Around Schools to be Safe 3Health News:Correction: Lawrence County Raw Milk Dairy Tests Negative for Campylobacter; Raw Milk Sales Resumed 2Health News:NHPCO Statement on MedPAC Recommendations to Congress 2Health News:NHPCO Statement on MedPAC Recommendations to Congress 3Health News:Many faces of diabetes in American youth: The SEARCH for diabetes in youth study 2Health News:Many faces of diabetes in American youth: The SEARCH for diabetes in youth study 3Health News:Many faces of diabetes in American youth: The SEARCH for diabetes in youth study 4
The 920M PLUS handheld pulseoximeter provides on-the-spot bloodoximetry and heart rate readings....
Rad-5 signal extraction pulse oximeter™...
... 3100 is a small, lightweight ... worn comfortably on the patients ... activities and for overnight studies, ... WristOx is intended to give ...
The pocket-size Invacare Digit finger pulse oximeter is a convenient and economical solution to fast, reliable SpO2, pulse rate and pulse strength measurements. Its compact size is ideal for home use...
Medicine Products: