Navigation Links
Regado Biosciences, Inc. Presents Two Abstracts on the Subcutaneous Depot Formulation of Pegnivacogin, a Nuclease-Stabilized RNA Aptamer, Direct Factor IXa Inhibitor and Part of the REG2 Anticoagulant System, at the American Heart Association (AHA)
Date:11/15/2010

BASKING RIDGE, N.J., Nov. 15, 2010 /PRNewswire/ -- Regado Biosciences, Inc., a privately held company leading the development of antithrombotic aptamers with active control agents, announced today two abstract presentations evaluating the potency and duration of a subcutaneous depot formulation of pegnivacogin (a.k.a. RB006), a nuclease-stabilized aptamer and direct Factor IXa inhibitor.  The studies were presented at the American Heart Association (AHA) Scientific Sessions meeting, on November 15, 2010.  

At 9:15 a.m. CST, Christopher Rusconi, Ph.D., Senior Vice President and Chief Scientific Officer, presented an abstract titled "Subcutaneous Administration of the Direct FIXa Inhibitor RB006 Provides Persistent Inhibition of Thrombin Generation."  The study examined the effects of RB006 in 28 healthy volunteers who received a single dose of 0.5, 1.0 or 3mg/kg RB006 or placebo administered subcutaneously. Results demonstrated potent, dose dependent inhibition of thrombin generation, which persisted through seven days, supporting dosing of no more than once a week.

At 11:00 a.m. CST, Steven L. Zelenkofske, D.O, F.A.C.C., Senior Vice President and Chief Medical Officer, presented an abstract titled "RB006 a Direct FIXa Inhibitor Provides Potent Concentration Dependent Suppression of Thrombin Generation."  This study was intended to better define potential dosing ranges of RB006 for future venous thromboembolism (VTE) studies.  Results revealed that while very low plasma concentrations of RB006 were needed to substantially affect the kinetics and extent of thrombin generation, very high levels of thrombin suppression could be achieved at higher plasma concentrations

The data from both abstracts are promising for future development of Regado's REG2 anticoagulant system, which consists of a subcutaneously administered depot formulation of RB006 paired with its matched active control agent, an IV bolus formulation of aniva
'/>"/>

SOURCE Regado Biosciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Regado Biosciences to Present at the IMPACT 2010 Conference in Philadelphia, Pennsylvania
2. Regado Biosciences, Inc. Presents the First-In-Human Clinical Experience with REG2 at the American College of Chest Physicians (ACCP) Coagulation and Heart Disease Sessions in Vancouver, BC, Canada on November 2, 2010
3. Regado Biosciences to Present at the Stifel Nicolaus Healthcare Conference 2010 on September 16, 2010 in Boston, Massachusetts
4. Regado Biosciences to Present at the 2010 Wells Fargo Healthcare Conference on June 24, 2010 in Boston, Massachusetts
5. Regado Biosciences, Inc. Introduces REG2, Its Second Product Candidate, at the American College of Cardiology Conference, 59th Annual Scientific Session, in Atlanta, Georgia on March 15, 2010
6. Regado Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference on December 1, 2009
7. Regado Biosciences to Present at the Ninth Annual Joint Symposium of BioNJ and Pennsylvania Bio on November 17, 2009
8. Regado Biosciences Releases Positive Phase 2a Data for the Reversible Anticoagulant System REG1 at the European Society of Cardiology Congress In Barcelona, Spain
9. Regado Biosciences Completes Patient Enrollment for Phase IIa Study of REG1 Anticoagulation System
10. Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008
11. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... , August 29, 2014 ... Oil Market by Extraction type (SFE, Cold Pressed, ... Personal Care, Pharmaceutical, Food Supplements, Fragrance, & Others) - ... MarketsandMarkets, defines and segments the Amaranth Seed Oil ... market size in terms of value. The Amaranth ...
(Date:8/29/2014)... 29, 2014   Vittamed Corporation , a neurodiagnostics medical ... today that T. (Teo) Forcht Dagi , MD, DmedSc, ... of Directors. " Teo Forcht Dagi ... medical innovation and venture capital," said Remis Bistras , ... add his clinical, strategic, and entrepreneurial expertise to our Board." ...
(Date:8/29/2014)... PITTSBURGH , Aug. 29, 2014 /PRNewswire-iReach/ -- ChemImage ... at the Australian and New Zealand Forensic Science ... Forensic Sciences in Adelaide, Australia ... discussion concerning the advancements that hyperspectral imaging can ... Jeffrey Beckstead , Director of Product Development ...
Breaking Medicine Technology:Amaranth Seed Oil Market worth $700.6 Million by 2019 2Amaranth Seed Oil Market worth $700.6 Million by 2019 3Amaranth Seed Oil Market worth $700.6 Million by 2019 4Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 2ChemImage to Discuss Hyperspectral Imaging for Forensic Investigation at the ANZFSS 22nd International Symposium on the Forensic Sciences 3
... (NASDAQ: IPHS ), the leading North American ... pharmaceutical, oral care and industrial end markets, today announced ... completed the acquisition of Kelatron Corporation. Kelatron ... of bioactive mineral nutrients. For over 30 years, the ...
... Filtrona Porous Technologies, a developer and manufacturer of custom ... will introduce a new range of hydrophilic, polyurethane foams ... COMPAMED trade fair in Dusseldorf, Germany from 16 to ... New innovations to be featured at ...
Cached Medicine Technology:Innophos Holdings, Inc. Announces Acquisition of Kelatron Corporation 2Filtrona Porous Technologies to Introduce New Hydrophilic Foam Products for Advanced Wound Care at the MEDICA / COMPAMED Trade Fair 2
(Date:9/1/2014)... 01, 2014 An operating theatre or ... for performing surgical operations. An operating room comprises a ... booms, operating room lights, imaging displays as well as ... by Transparency Market Research, a U.S.-based market research firm, ... USD 4.5 billion by 2019. , According to ...
(Date:9/1/2014)... "Women struggle with weight gain typically associated to ... early as 15, if not earlier. Women therefore ... downs of hormone related weight gain. The battle ... to rage against the hidden and ever-present hormones which ... begin to face menopause and related changes, these hormonal ...
(Date:9/1/2014)... By Dennis Thompson ... -- An experimental Ebola drug previously given to two American ... the deadly virus in laboratory tests, researchers report. The ... it, even if they didn,t get the medication until five ... cases of Ebola who were days or even hours away ...
(Date:9/1/2014)... atrial fibrillation (AF) doubles the risk of stroke compared ... 6 000 patients presented at ESC Congress today by ... a simple clinical assessment of the type of AF ... Ischaemic stroke is the second cause of death in ... many more disabled patients each year. Annual direct health ...
(Date:9/1/2014)... (PRWEB) September 01, 2014 The National ... to announce that Dawn Bazarko, DNP, MPH, RN, and ... of the American Academy of Nursing. They will be ... RN-BC, CCM, FACHE, whose induction we reported last May. ... 18, 2014, during the 2014 American Academy of Nursing ...
Breaking Medicine News(10 mins):Health News:Operating Room Equipment Market Study 2019 by Transparency Market Research 2Health News:Operating Room Equipment Market Study 2019 by Transparency Market Research 3Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 2Health News:Female Hormonal Imbalances - Can’t Seem to Shed Those Extra Pounds? Discussion with Medical Expert Dr. Clairborne on Dr. Carol Francis Talk Radio Today 3Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 2Health News:Monkey Trial Supports Ebola Drug That May Have Helped 2 Stricken Americans 3Health News:Permanent AF doubles risk of stroke compared to paroxysmal AF 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4
... go indoors, , , SATURDAY, July 12 (HealthDay News) -- Summer ... so it is also the time for them to be ... is, ,When thunder roars, go indoors," Mary Ann Cooper, director ... Illinois at Chicago, said in a prepared statement. "Decisions about ...
... Emageon Inc.,(Nasdaq: EMAG ), a leader ... networks and imaging facilities,announced today that the Strategic ... Jefferies and Company as Lead Advisor and SunTrust,Robinson ... it evaluates all,strategic options available to the company., ...
... MANHATTAN BEACH, Calif., July 11 A,democratic process involving ... July 14 with hearings to determine the best way ... have the greatest strength,to win for their families and ... step in a thorough, open, and democratic,discussion to make ...
... $500 million in cuts, WASHINGTON, July 11 ... and pay more out of pocket,for health care, while ... legislation approved this week by the U.S. Congress., ... from the,Medicare Advantage program over a five-year period, including ...
... Texas, July 11 Abuelo,s restaurants today,released the ... been linked to consumption of certain raw jalapeno ... recommendation of the Centers for Disease Control (CDC),Abuelo,s ... our recipes and,plate presentations at this time. We ...
... In New York, the majority of Medicaid LTC Funds ... A new report by AARP,s,Public Policy Institute finds mixed ... long-term care (LTC) options under Medicaid.,According to the report, ... Medicaid LTC dollars for older people providing home and ...
Cached Medicine News:Health News:Summer Is Peak Time for Lightning Strikes 2Health News:Florida Seniors' Medicare Advantage Benefits at Risk 2Health News:New AARP Report Finds Mixed Results Among State Governments' Efforts to Balance Long Term Care Services Under Medicaid 2Health News:New AARP Report Finds Mixed Results Among State Governments' Efforts to Balance Long Term Care Services Under Medicaid 3
... Eppendorf Reference Series 2000 Pipette is a ... a compact and robust design, and superior ... used to operate the measuring stroke and ... Product features:Eppendorf "pipette/tip" system ensures utmost accuracy ...
... Finnpipette Focus from Thermo Labsystems ... ergonomics with uncompromising performance. ... offers a custom fit for ... shorter tip cones allow easier ...
... Focus from Thermo Labsystems was ... with uncompromising performance. The ... a custom fit for different ... tip cones allow easier and ...
... Finnpipette Focus from Thermo Labsystems ... ergonomics with uncompromising performance. ... offers a custom fit for ... shorter tip cones allow easier ...
Medicine Products: