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Regado Biosciences, Inc. Presents Two Abstracts on the Subcutaneous Depot Formulation of Pegnivacogin, a Nuclease-Stabilized RNA Aptamer, Direct Factor IXa Inhibitor and Part of the REG2 Anticoagulant System, at the American Heart Association (AHA)
Date:11/15/2010

BASKING RIDGE, N.J., Nov. 15, 2010 /PRNewswire/ -- Regado Biosciences, Inc., a privately held company leading the development of antithrombotic aptamers with active control agents, announced today two abstract presentations evaluating the potency and duration of a subcutaneous depot formulation of pegnivacogin (a.k.a. RB006), a nuclease-stabilized aptamer and direct Factor IXa inhibitor.  The studies were presented at the American Heart Association (AHA) Scientific Sessions meeting, on November 15, 2010.  

At 9:15 a.m. CST, Christopher Rusconi, Ph.D., Senior Vice President and Chief Scientific Officer, presented an abstract titled "Subcutaneous Administration of the Direct FIXa Inhibitor RB006 Provides Persistent Inhibition of Thrombin Generation."  The study examined the effects of RB006 in 28 healthy volunteers who received a single dose of 0.5, 1.0 or 3mg/kg RB006 or placebo administered subcutaneously. Results demonstrated potent, dose dependent inhibition of thrombin generation, which persisted through seven days, supporting dosing of no more than once a week.

At 11:00 a.m. CST, Steven L. Zelenkofske, D.O, F.A.C.C., Senior Vice President and Chief Medical Officer, presented an abstract titled "RB006 a Direct FIXa Inhibitor Provides Potent Concentration Dependent Suppression of Thrombin Generation."  This study was intended to better define potential dosing ranges of RB006 for future venous thromboembolism (VTE) studies.  Results revealed that while very low plasma concentrations of RB006 were needed to substantially affect the kinetics and extent of thrombin generation, very high levels of thrombin suppression could be achieved at higher plasma concentrations

The data from both abstracts are promising for future development of Regado's REG2 anticoagulant system, which consists of a subcutaneously administered depot formulation of RB006 paired with its matched active control agent, an IV bolus formulation of aniva
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SOURCE Regado Biosciences, Inc.
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