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Regado Biosciences, Inc. Introduces REG2, Its Second Product Candidate, at the American College of Cardiology Conference, 59th Annual Scientific Session, in Atlanta, Georgia on March 15, 2010
Date:3/15/2010

BASKING RIDGE, N.J., March 15 /PRNewswire/ -- Regado Biosciences, Inc.,  a privately held company leading the development of antithrombotic aptamers with active control agents, announced that Chris Rusconi, PhD, Senior Vice President, Chief Scientific Officer and Steven Zelenkofske, DO, FACC, Senior Vice President , Chief Medical Officer presented an abstract at the American College of Cardiology on Monday, March 15, 2010 in Atlanta, Georgia.   The poster, entitled "Subcutaneous FIXa Inhibitor Provides Prolonged Anticoagulation: The First Successful Subcutaneous Application of an Aptamer," is the first presentation of data from Regado's pre-clinical study of its REG2 anticoagulation system, currently in Phase 1 human clinical testing. The REG2 system is Regado's second product candidate in development, which consists of a subcutaneously administered formulation of the specific Factor IXa inhibitor, RB006, paired with an IV bolus formulation of its complementary active control agent, RB007. The abstract is coauthored by Doug Kornbrust, Chris Rusconi and Steven Zelenkofske from Regado Biosciences. "We were pleased to find that the subcutaneous administration of RB006 was well tolerated in primates and achieved prolonged anticoagulation that was reversible by RB007.  This represents the first successful subcutaneous application of an aptamer," stated Dr. Rusconi.  In addition, Dr. Zelenkofske added:  "The prolonged anticoagulant effect and reversibility may provide a new approach to sub-acute anticoagulation for future clinical applications."


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