Navigation Links
Regado Biosciences, Inc. Introduces REG2, Its Second Product Candidate, at the American College of Cardiology Conference, 59th Annual Scientific Session, in Atlanta, Georgia on March 15, 2010
Date:3/15/2010

BASKING RIDGE, N.J., March 15 /PRNewswire/ -- Regado Biosciences, Inc.,  a privately held company leading the development of antithrombotic aptamers with active control agents, announced that Chris Rusconi, PhD, Senior Vice President, Chief Scientific Officer and Steven Zelenkofske, DO, FACC, Senior Vice President , Chief Medical Officer presented an abstract at the American College of Cardiology on Monday, March 15, 2010 in Atlanta, Georgia.   The poster, entitled "Subcutaneous FIXa Inhibitor Provides Prolonged Anticoagulation: The First Successful Subcutaneous Application of an Aptamer," is the first presentation of data from Regado's pre-clinical study of its REG2 anticoagulation system, currently in Phase 1 human clinical testing. The REG2 system is Regado's second product candidate in development, which consists of a subcutaneously administered formulation of the specific Factor IXa inhibitor, RB006, paired with an IV bolus formulation of its complementary active control agent, RB007. The abstract is coauthored by Doug Kornbrust, Chris Rusconi and Steven Zelenkofske from Regado Biosciences. "We were pleased to find that the subcutaneous administration of RB006 was well tolerated in primates and achieved prolonged anticoagulation that was reversible by RB007.  This represents the first successful subcutaneous application of an aptamer," stated Dr. Rusconi.  In addition, Dr. Zelenkofske added:  "The prolonged anticoagulant effect and reversibility may provide a new approach to sub-acute anticoagulation for future clinical applications."

ABOUT REGADO BIOSCIENCES

Regado Biosciences is pioneering a new therapeutic technology with the creation and development of two-component drug systems.  Each system comprises a nuclease-stabilized RNA aptamer that can be controlled directly by its specific and complementary oligonucleotide active control agent.  This technology is being applied to injectable antithrombotics, including anticoagulants and antiplatelet agents, a multi-billion dollar market in need of therapeutics with improved safety profiles and a greater degree of therapeutic control.  Regado's technology is designed to give physicians the ability to actively and directly control each system's therapeutic effect providing a safe and unique approach to personalized medicine.

ABOUT REG1 and REG2

Regado's lead program, the anticoagulant system REG1, consists of two parenteral agents both administered by IV bolus, the first being a potent highly selective Factor IXa inhibitor (RB006) and the second being its complementary active control agent (RB007).  RB007 can be used to selectively completely or partially reverse the anticoagulant effect of RB006.  REG1, presently in phase 2b clinical trial, is intended for application in arterial thrombosis applications, initially in Acute Coronary Syndrome patients undergoing Percutaneous Coronary Intervention.  REG2, Regado's second product candidate, consists of a subcutaneously administered depot formulation of RB006 paired with the IV bolus formulation of RB007.  REG2 recently completed single escalating dose phase 1 clinical testing and is planned to be studied in a multiple escalating dose clinical trial later in 2010.  It is intended for use in venous thrombosis indications such as venous thromboembolism (VTE) prophylaxis in patients undergoing abdominal surgery.  Information pertaining to Regado's clinical programs may be obtained at www.clinicaltrials.gov.

ABOUT APTAMERS

RB006 is a member of a class of compounds called aptamers.  Aptamers are single stranded oligonucleotides that adopt a specific conformation enabling direct, specific inhibition of the targeted protein.  A key unique feature of aptamers derives from the fact that they are formed from nucleic acids.  As such, their pharmacologic activity can be controlled by a matched, complementary oligonucleotide active control agent (the Watson-Crick base pair complement of a fraction of the agent to be controlled), which can bind to the aptamer, removing it from its target and reversing it biologic effects.

More information can be found at www.regadobio.com

SOURCE Regado Biosciences, Inc.

Back to top

RELATED LINKS
http://www.regadobio.com

'/>"/>

SOURCE Regado Biosciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Regado Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference on December 1, 2009
2. Regado Biosciences to Present at the Ninth Annual Joint Symposium of BioNJ and Pennsylvania Bio on November 17, 2009
3. Regado Biosciences Releases Positive Phase 2a Data for the Reversible Anticoagulant System REG1 at the European Society of Cardiology Congress In Barcelona, Spain
4. Regado Biosciences Completes Patient Enrollment for Phase IIa Study of REG1 Anticoagulation System
5. Regado Biosciences Reports Clinical Results for REG1 Anticoagulation System at European Society of Cardiology Congress 2008
6. Regado Biosciences Announces Publication in Circulation of Clinical Trial Results of REG1 Anticoagulation System
7. Regado Biosciences Presents Early Stage Clinical Data for REG1 Anticoagulation System at American Heart Association 2007 Scientific Sessions
8. Regado Biosciences Presents Positive Data From REG1 Anticoagulation System Phase Ic Study at American Heart Association 2007 Scientific Sessions
9. Regado Biosciences Initiates Phase IIa Clinical Study of REG1 Anticoagulation System
10. Neurocrine Biosciences, Inc. Prices Common Stock Offering
11. Hollis-Eden Announces Name Change to Harbor BioSciences, Inc. and Ticker Symbol Change to HRBR
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... FRANCISCO , February 9, 2016 ... biotechnology company focused on developing products for Regenerative Medicine, ... be a featured presenting company at Source Capital Group,s ... on February 10-11, 2016 in New York ... on Wednesday, February 10, 2016 at 12:30 pm by ...
(Date:2/9/2016)... 9, 2016 Hearing protection devices refer to ... transmitted to the inner ear. Hearing protection devices include ... devices are recommended for users exposed to noise levels ... to HPD that are inserted in the ear canal ... to provide more natural sound perception with the help ...
(Date:2/9/2016)... -- The leader in accelerated orthodontics, OrthoAccel ® ... recipient of the 2015 Townie Choice Award in the ... device that speeds up orthodontic tooth movement by as ... with treatment, AcceleDent was selected by orthodontists from across ... survey of the most reliable and reputable products ...
Breaking Medicine Technology:
(Date:2/9/2016)... ... ... The Journal of Pain Research has published the commentary “ Terminology of ... Dr John F. Peppin says “Terminology matters, yet little attention has been paid to ... cancer pain’ and ‘chronic non-cancer pain’ are replete in the literature; however, the distinction ...
(Date:2/9/2016)... ... February 09, 2016 , ... METTLER TOLEDO has published ... have a basic understanding of the techniques they use so they can more ... them reduce waste and rework to create a leaner overall lab experience. ...
(Date:2/9/2016)... Atlanta, G.A. (PRWEB) , ... February 09, 2016 ... ... tile and grout cleaning and sealing company , is proud to announce that ... for their superior levels of customer service. The hard surface restoration franchises received ...
(Date:2/8/2016)... PLAINSBORO, N.J. (PRWEB) , ... February 08, 2016 , ... ... on cancer patients, has officially launched the Multiple Myeloma Heroes Awards event , ... (MM) or in the lives of patients with MM. The MM Heroes Awards ...
(Date:2/8/2016)... , ... February 08, 2016 , ... ... in Houma, LA, celebrates the beginning of a new charity campaign. As part ... Court Appointed Special Advocates (CASA). In the belief that children deserve a voice, ...
Breaking Medicine News(10 mins):