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Reduced Lung Capacity Accelerates With Diabetes
Date:3/26/2008

l capacity as they age, people with diabetes appear to undergo a more rapid loss that appears before the diabetes diagnosis and accelerates after the disease sets in.

This could be because high blood sugar levels stiffen the lung tissue, or because the fat tissue in the chest and abdomen may confine the lungs more in people with diabetes, explained the researchers. They concluded the study with advice to clinicians to "pay heightened attention to pulmonary function in their patients with type 2 diabetes."

"Think of the lung as a crime victim who unwittingly abets the perpetrator to hasten the demise of the host," wrote Dr. Connie Hsia, of the University of Texas Southwestern Medical Center's Department of Internal Medicine, in an editorial accompanying the study. She suggested that the loss of pulmonary function could add to diabetic morbidity and mortality, and raised concerns about the potential use of inhaled insulin, since it may "trigger or exacerbate pulmonary dysfunction."

Recently, makers of inhaled insulin have pulled their products from the market because of poor sales or halted product investigations, though several companies continue to explore this type of insulin delivery.

"Manufacturers of inhaled insulin should find these data useful as they study potential long-term effects of their product on lung function," said Dr. Fred Brancati, one of the lead researchers on the study. "The results suggest that doctors and patients should keep an eye on the literature about diabetes and the lung down the road, since there's a stronger connection than we previously thought."

Consensus Statement Urges Greater Lipid Control

The ADA-American College of Cardiology (ACC) paper highlights a new consensus suggesting that, in people who exhibit cardiometabolic risk factors (such as insulin resistance, hypertension, overweight/obesity, or a family history of premature heart disease), a certain protein called apolipo
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SOURCE American Diabetes Association
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