Navigation Links
Reata and Abbott Initiate Global Phase 3 Study of Bardoxolone Methyl in Patients With Chronic Kidney Disease and Type 2 Diabetes
Date:6/16/2011

IRVING, Texas and ABBOTT PARK, Ill., June 16, 2011 /PRNewswire/ -- Reata Pharmaceuticals, Inc. and Abbott announced today the initiation of a pivotal Phase 3 clinical trial to evaluate the safety and efficacy of bardoxolone methyl in patients with chronic kidney disease (eGFR of 15-29 mL/min/1.73 m2) and type 2 diabetes.

The trial, known as BEACON (Bardoxolone methyl EvAluation in patients with Chronic kidney disease and type 2 diabetes: the Occurrence of renal eveNts), is the first multinational, double-blind, placebo-controlled study designed to assess the impact of bardoxolone methyl on time to important clinical outcomes. Approximately 1,600 patients at 300 sites worldwide – including in Austria, Australia, Belgium, Canada, Czech Republic, France, Germany, Israel, Italy, Mexico, Spain, Sweden, United Kingdom and United States – will be enrolled in the trial and  randomized 1:1 to receive 20 mg of a reformulated version of bardoxolone methyl or placebo once daily.  Results are expected in 2013.

The primary efficacy endpoint will be a time-to-first-event composite consisting of progression to end-stage renal disease (ESRD), defined as the need for chronic dialysis or renal transplant, and cardiovascular death. Secondary endpoints will include change in estimated glomerular filtration rate (eGFR) and a time-to-first-event composite consisting of hospitalization for congestive heart failure (CHF), non-fatal myocardial infarction (MI), non-fatal stroke and cardiovascular death.

More information on the trial is available at www.clinicaltrials.gov (clinical trial identifier: NCT01351675).

"We are pleased to announce that the Phase 3 BEACON trial is underway," said Pablo E. Pergola, M.D., Ph.D., Director of Renal Associates' Research Di
'/>"/>

SOURCE Abbott
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Public Forum to Discuss Addiction as a Treatable Disease and Highlight National Alcohol and Drug Addiction Recovery Month
2. Oxford Finance Corporation Facilitates Entry for Reata Pharmaceuticals into Asian Markets
3. Abbott and Reata Pharmaceuticals Announce Agreement to Develop and Commercialize Bardoxolone Methyl for Chronic Kidney Disease Outside the U.S.
4. Reata Pharmaceuticals to Present Data from Pivotal Phase 2b Trial in Type 2 Diabetics With Chronic Kidney Disease
5. Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test
6. Abbott and AstraZeneca Announce Selection of Next-Generation Fenofibrate ABT-335 and CRESTOR(R) Fixed-Dose Combination
7. Abbott Initiates Clinical Study to Evaluate Use of RX Herculink(R) Elite(TM) Renal Stent System for the Treatment of Renal Artery Stenosis
8. Abbotts ABT-874 Shows Positive Results for Maintenance of Response in Phase II Psoriasis Study
9. Abbotts XIENCE(TM) V Everolimus Eluting Coronary Stent Shows Continued Superiority to TAXUS Stent in Reducing Major Adverse Cardiac Events in SPIRIT III Clinical Trial
10. Abbott Announces Positive One-Year Results from the Worlds First Clinical Trial of a Fully Bioabsorbable Drug Eluting Coronary Stent
11. Abbotts m2000(TM) Molecular Diagnostic Instrument and RealTime HIV-1 Test Win Chicago Innovation Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 28, 2014 China Nepstar Chain Drugstore ... "Company"), a leading retail drugstore chain in China ... today announced its unaudited financial results for the ... HighlightsFor the quarter ended June 30, 2014: , ... compared to RMB638.8 million in the second quarter ...
(Date:8/27/2014)... LONDON , Aug. 27, 2014 /PRNewswire/ ... research report: Co-development Terms & ... https://www.reportbuyer.com/product/2276221/Co-development-Terms--Agreements-in-Pharma-Biotech-and-Diagnostics.html The ... and Diagnostics report provides comprehensive understanding and ... agreements entered into by the worlds leading ...
(Date:8/27/2014)... About 8 million Americans have peripheral arterial ... fatty plaque in the arteries, according to recent statistics. ... in incidences of diabetes and obesity, the Society ... Arterial RevascularizatioN (LEARN) meeting, Oct. 9–11 in ... residents and fellows will be able to gain state-of-the-art ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 2China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 3China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 4China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 5China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 6China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 7China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 8China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 9China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 10China Nepstar Chain Drugstore Ltd. Reports Second Quarter 2014 Financial Results 11Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 2Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 3Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 4Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 5Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 6Co-development Terms & Agreements in Pharma, Biotech and Diagnostics 7LEARN to Treat Peripheral Arterial Disease Patients 2LEARN to Treat Peripheral Arterial Disease Patients 3
... ANGELES and OAKLAND, Calif., March 15, 2012  With the ... community clinics face unprecedented challenges. To flourish, clinics now ... To facilitate this change in strategy, ... Finance Fund (NFF), announces the California Catalyst Fund ...
... Inc., a clinical-stage biopharmaceutical company developing novel oncology therapeutics ... bulk, today announced that Kevin Buchi has joined its ... Executive Officer of Cephalon, Inc. through its $6.8 billion ... ) in October 2011, Mr. Buchi has served as ...
Cached Medicine Technology:New Restructuring Fund Launches for California Community Clinics 2Stemline Therapeutics Appoints Kevin Buchi, Former CEO of Cephalon, to Its Board of Directors 2
(Date:8/28/2014)... 28, 2014 InventHelp, a ... clients, an inventor from California, has designed an alternative ... invention is patented. , The “Abdominal Swimming Support” is ... risk of injuries from physical activity if one is ... or muscular atrophy. Ideal for use as a ...
(Date:8/28/2014)... August 28, 2014 Altec Products, ... workflow solutions, announced today that they have been ... SoCal Chapter of the International Association of Microsoft ... IAMCP was founded in 1994, providing Microsoft Partners ... the IT community at large while facilitating mutual ...
(Date:8/28/2014)... 28, 2014 Dr. Stewart Shofner ... patients throughout the summer that recently headed off to ... Statistics, over 22 million students will attend college ... spend their time attending classes, studying for exams, participate ... risk of eye problems. , Dr. Stewart Shofner ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 A leading Florida ... possibility of suicide contagion as a result of media coverage ... is an increased risk of ‘copycat suicides’ among the general ... focus should not be on what happened—the suicide itself—but on ... to suicide. , “Suicide is a tragedy on so ...
(Date:8/28/2014)... Registration is now open for the ... Holmdel, New Jersey on Sunday, October 19, 2014. This ... Jersey Vietnam Veterans’ Memorial adjacent to the Vietnam Era ... Center. All proceeds of the event will benefit Hope ... a sense of self, restoring the family unit, and ...
Breaking Medicine News(10 mins):Health News:InventHelp® Client Patents “Abdominal Swimming Support” – Invention Could Serve as an Alternative Flotation Device 2Health News:Altec and Bond Consulting Services Receive Award from the International Association of Microsoft Channel Partners SoCal Chapter 2Health News:Altec and Bond Consulting Services Receive Award from the International Association of Microsoft Channel Partners SoCal Chapter 3Health News:Renowned Eye Surgeon Dr. Shofner Shares Five Important Vision Tips For College Students 2Health News:Renowned Eye Surgeon Dr. Shofner Shares Five Important Vision Tips For College Students 3Health News:Sylvia Brafman Mental Health Center Warns of Suicide Contagion Following Robin Williams’ Death 2Health News:Hope For The Warriors Announces Second Annual NJ Run 2
... LONDON, May 11 , - Health of the Nation ... - Britain is Overwhelmed, Overworked and Overweight, - ... The nation appears to be stuck in a ... save time and,money by cutting back on exercise and healthy foods in ...
... in Patient SatisfactionSOUTH BEND, Ind., May 11 In ... is proud to recognize all of its hospital partners ... care they provide."The doctors, nurses, and staff at our ... they deserve to be commended," said Rick Siegrist, Press ...
... man had underlying health problems, officials say , , SUNDAY, ... his 30s from Snohomish County, Wash., is the third person ... health officials said late Saturday. , In a Department of ... underlying heart condition, died last week with what appear to ...
... says outbreak continues, but infections still mild and recovery is ... The swine flu count in the United States now stands ... states, with 104 hospitalizations, federal health officials said Saturday. , ... find them," Dr. Anne Schuchat, interim deputy director for science ...
... when it comes to breast reconstruction surgery. Park Meadows Cosmetic ... guide to a variety of breast reconstruction options. , ... ... than a quarter million American women are diagnosed with breast cancer. ...
... Proponent Offers Special Membership Rate through June 30, 2009PLYMOUTH ... most important family holidays almost upon us, adult children ... Mom and/or Dad. Health Proponent, the consumer division ... company, has the solution: Why not give parents ...
Cached Medicine News:Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 2Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 3Health News:Stressed and Sedentary Lifestyles Increase as Recession Appears to Take its Toll on Britain's Health 4Health News:Press Ganey Supports National Hospital Week 2Health News:Press Ganey Supports National Hospital Week 3Health News:Third U.S. Swine Flu Death Reported 2Health News:Third U.S. Swine Flu Death Reported 3Health News:Third U.S. Swine Flu Death Reported 4Health News:Third U.S. Swine Flu Death Reported 5Health News:Third U.S. Swine Flu Death Reported 6Health News:Third U.S. Swine Flu Death Reported 7Health News:Third U.S. Swine Flu Death Reported 8Health News:Third U.S. Swine Flu Death Reported 9Health News:Third U.S. Swine Flu Death Reported 10Health News:Third U.S. Swine Flu Death Reported 11Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 2Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 3Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 4Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 5Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 6Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 7Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 8Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 9Health News:Confirmed Swine Flu Cases in U.S. Near 2,300 Mark 10Health News:Park Meadows Cosmetic Surgery, a Pioneer in DIEP Flap Breast Reconstruction Surgery in Colorado, Introduces New, Informative Website 2Health News:Park Meadows Cosmetic Surgery, a Pioneer in DIEP Flap Breast Reconstruction Surgery in Colorado, Introduces New, Informative Website 3Health News:Show Mom and Dad You Care Every Day of the Year; Give the Gift of Health Advocacy this Mother's and Father's Days 2Health News:Show Mom and Dad You Care Every Day of the Year; Give the Gift of Health Advocacy this Mother's and Father's Days 3
... the semi-quantitative determination of specific IgA autoantibodies ... of the anti-Gliadin IgA assay can be ... of diseases associated with elevated levels of ... these autoantibodies are one indicator in a ...
... ADVIA Urinalysis WorkCell System - A ... tests per hour, with true load-and-go ... of Clinitek Atlas and UF-100 for ... regarded systems working together deliver utmost ...
... (EIA) test kit is to be used ... in human serum during the second half ... (unconjugated) procedure is an enzyme immunoassay which ... binding. In the procedure, estriol is ...
Assay uses highly specific rabbit anti-estriol antibody reparation - negligible cross-reactivity with other estrogen metabolites. Excellent assay precision and reproducibility. Superior sensitivity ...
Medicine Products: