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Raptor Pharmaceutical Corp. Announces Positive Data on NGX426 in the Potential Treatment of Neuropathic Pain
Date:11/23/2009

e time point on reduction of spontaneous pain, hyperalgesia (increased sensitivity to pain) and allodynia (pain due to a stimulus which does not normally provoke pain). After the 120 minute time point, the 90 mg dose was statistically significant for hyperalgesia and allodynia. NGX426 was well tolerated, all subjects completed the three treatment periods, and the most common adverse events attributed to NGX426 were mild somnolence and dizziness.

Dr. Wallace commented, "Human experimental models of pain, such as this used in this study, are emerging as tools to predict efficacy of novel analgesics early in the clinical trial process. These results for NGX426 are exciting because they suggest that this drug could be effective in real-world, clinical pain states. Having worked in both patient care and in the research of state of the art therapies for the management of chronic pain, I'm always excited to see a new potential product deliver encouraging data. These proof-of-concept results support further clinical development for NGX426 as well as its companion drug, tezampanel, as potential non-opioid treatments for pain."

Christopher M. Starr, Ph.D., Chief Executive Officer of Raptor, commented, "We are encouraged by these results suggesting that NGX426 could be effective in the treatment of acute pain such as migraine and chronic pain, such as neuropathy. NGX426 has been administered to 182 male and female healthy subjects in single and multiple doses and all doses of NGX426 were well-tolerated with no serious or medically important adverse events reported. We believe the pain indication could benefit from such a safety profile and potential efficacy profile. We plan to continue to explore our options with NGX426 in the treatment of pain, and we are actively looking for partners or collaborators regarding the development of this product candidate."

About Raptor Pharmaceutical Corp.


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