Navigation Links
Ranolazine Shortens QT Interval and Improves Cardiac Relaxation in Study of Patients With Genetic Sodium Channel Disorder
Date:3/31/2008

- Clinical evidence for unique Ranexa(R) mechanism of action -

CHICAGO, March 31 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. (Nasdaq: CVTX) announced today that ranolazine significantly (p<0.001) shortened the QT interval of patients with a hereditary form of long QT syndrome called LQT3, which is caused by a genetic mutation in the late sodium channel and can be associated with heart rhythm problems, including sudden death. Ranolazine also shortened cardiac relaxation time in the study.

The data were presented today at the American College of Cardiology 57th Annual Scientific Session in Chicago by Arthur Moss, MD, professor of medicine (cardiology) and director of the heart research follow-up program at the University of Rochester Medical School.

"Since individuals with LQT3 syndrome have a defect in the specific sodium channel where ranolazine has its activity, it makes sense that we are seeing ranolazine shorten the QT interval and improve cardiac relaxation in these patients," Moss said.

Five patients with LQT3 syndrome were prospectively investigated during an eight hour intravenous infusion of ranolazine, with ECG and ECHO evaluation before, during and after ranolazine administration.

In December 2007, the U.S. Food and Drug Administration approved new language for the product labeling for Ranexa(R) (ranolazine extended-release tablets) which describes the ability of ranolazine to inhibit the late sodium current at therapeutic levels.

Published data on ranolazine's mechanism of action suggests that during ischemic episodes excess sodium can flow into cardiac cells through sodium channels. This excess sodium can lead to calcium overload, which in turn can lead to impaired relaxation of
'/>"/>

SOURCE CV Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Study Confirms That New Protocol Shortens the Time It Takes to Open Blocked Arteries for Heart Attack Patients
2. Experimental Drug Ketasyn(TM) Improves Memory in Age-Associated Memory Impairment Study
3. First Osteoporosis Study in Hip Fracture Patients Finds Once-Yearly Reclast(R) Prevents Additional Fractures and Improves Survival
4. New England Journal of Medicine Study Shows ERBITUX(R) Improves Survival in Advanced Colorectal Cancer
5. TREANDA Significantly Improves Clinical Outcomes in Patients with Chronic Lymphocytic Leukemia Compared to Chlorambucil
6. New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies
7. Oral Talactoferrin Alfa Improves Overall Survival in Patients With Refractory Non-Small Cell Lung Cancer: Final Phase 2 Study Results Presented at the 8th Annual Targeted Therapies for the Treatment Of Lung Cancer Meeting
8. Tailored Clopidogrel Dosing Improves PCI Outcomes
9. Personalized Medicine - The Genomic Revolution in Cardiac Care
10. FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function
11. Signalife Completes Testing of Modules for Holter and Intra-Cardiac Monitor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... DUBLIN , Dec. 22, 2014 Research ... announced the addition of the "Investment Analysis ... report to their offering. ... investments in the US medical device sector identifies ... equity and venture capital investments, and mergers and ...
(Date:12/22/2014)... Cyberonics, Inc. (NASDAQ: CYBX ), a ... of epilepsy, today announced it will participate in the 33 ... 14, 2015, in San Francisco . ... Officer, will speak at 11:00 AM Pacific Time.  A live ... on the Investor Relations link on the Cyberonics home page ...
(Date:12/22/2014)... 2014 /PRNewswire/ -- RXi Pharmaceuticals Corporation (NASDAQ: ... developing and commercializing innovative therapies addressing major unmet ... following open letter to shareholders from President & ... Dear RXi Shareholders, In ... statements posted on certain social media sites seem ...
Breaking Medicine Technology:Investment Analysis of the US Medical Device Sector 2RXi Pharmaceuticals Issues Open Letter to Shareholders 2RXi Pharmaceuticals Issues Open Letter to Shareholders 3RXi Pharmaceuticals Issues Open Letter to Shareholders 4RXi Pharmaceuticals Issues Open Letter to Shareholders 5RXi Pharmaceuticals Issues Open Letter to Shareholders 6
... , June 21 Ethicon Endo-Surgery, Inc. ... line of surgical devices, the HARMONIC ACE® 45 cm ... the reach of surgeons for minimally invasive procedures involving ... the standard length HARMONIC ACE® device. The additional length ...
... 21 Pfizer Inc. (NYSE: PFE ) announced today ... it will be discontinuing commercial availability of Mylotarg® (gemtuzumab ozogamicin for Injection) ... the United States and that it will be voluntarily withdrawing the ... , , , ...
Cached Medicine Technology:Ethicon Endo-Surgery Introduces HARMONIC ACE® 45 cm Curved Shears at ASMBS 2Ethicon Endo-Surgery Introduces HARMONIC ACE® 45 cm Curved Shears at ASMBS 3Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 2Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 3Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 4Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 5Pfizer Prepares for Voluntary Withdrawal of U.S. New Drug Application and for Discontinuation of Commercial Availability of Mylotarg® 6
(Date:12/26/2014)... It is said that nothing makes a lady feel ... wedding dress supplier, shows its new selection of navy ... , UWDress.com’s navy cocktail gowns are the cornerstones of ... fashion styles. Simple dresses in bright neon colors can be ... specially designed for those who want to shine among the ...
(Date:12/26/2014)... December 26, 2014 The Biofeedback Federation ... March 24-28, 2015 in Rome, Italy and is hosted ... workshops on a wide variety of topics ... as peak performance training in athletes. The scientific program ... world. , Biofeedback monitoring allows clients to see what ...
(Date:12/26/2014)... India Network Foundation, a non-profit US based ... today a new version of “ EasySelect ”, a ... plan for their visiting parents. The technology tool is ... process when choosing an insurance plan by showing the ... few clicks. Many elderly Asian Indian parents often find ...
(Date:12/26/2014)... Parker & Sons, Inc. a reliable ... cooling and plumbing contractor services throughout Arizona announces ... 2014 with regard to air-conditioning systems. Residential and ... for its incredibly hot summers. Working with an ... details of a wide variety of systems made ...
(Date:12/25/2014)... The click strand woven bamboo ... durability. Today, the business announces a click strand ... Jan. 30, 2015. , Click strand woven bamboo ... is a well-known brand in the bamboo industry. ... a reliable bamboo flooring supplier. , “We are ...
Breaking Medicine News(10 mins):Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2Health News:Final Workshop Line-up Announced for 18th Annual Biofeedback Conference in Rome, Italy 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 2Health News:India Network Health Insurance Announces new Comprehensive Pre-existing Condition Coverage policy for Visitors to the United States 3Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2
... Haglund’s syndrome, a common running ailment, can be treated in ... Adler, chief, Division of Ultrasound// and Body CT, the ultrasound ... relieve the pain of the patient. ,One condition ... painful bump on the back of the heel, caused by ...
... (AU) and the UN system in Africa on Tuesday launched ... Region//. Aids prevention matters were the top priority at the ... The programme aims to curb the spread on the pandemic, ... Oumar Konare said at a launching ceremony, held at the ...
... than 1lb 6oz. He was so weak that he needed life ... he lived and grew stronger. //Even his mother Donna Morgan who ... be given blood transfusions to recover. ,Now the mother ... helped them, they are launching a campaign to fill the worryingly ...
... lithotripsy, which is given for treating kidney stones have increased ... of life. //Risk for diabetes was related to the intensity ... hypertension was related to treatment of stones in both kidneys. ... up an impassable kidney stone into smaller, sandlike pieces which ...
... said that suicide rates in Sri Lanka has increased in multifold ... oleander plants even for the most trivial reasons. ,This ... over the island. It has yellow trumpet-like flowers and a fruit ... and one of these seeds is enough to kill you, the ...
... Health Minister Ashok Bhatt has confirmed the absence of bird-flu ... bird-flu// also yielded negative results. ,Kadar Murghiwala, a ... his care died. Suspecting a possible bird-flu infection following complaints ... kept in an isolation ward. The symptoms of bird-flu as ...
Cached Medicine News:Health News:Proper Diagnosis Could Augment Speedy Recovery Of Haglund’s Syndrom 2Health News:African Union Launches A Programme On Acceleration of HIV Prevention 2Health News:Shock Wave Therapy Increase The Risk Of Diabetes 2Health News:Shock Wave Therapy Increase The Risk Of Diabetes 3
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,407-0) or contact custom...
Pipetman P is a fully adjustable, air-displacement pipette with the selected volume shown on a digital indicator (volumeter). Eight models cover the full range of volumes from 0.2 L to 10 mL....
... is the #1 Pipettor for sub-microliter ... and reliability. Continuously adjustable. Features lPLUS, ... Easy interchangeable ejector buttons to fit ... rapid pipet tip ejector with three ...
... digital models cover the range from 2ul to ... Volume lock design prevents inadvertent volume change. ... grip. Whole pipette is autoclavable at 121C(250F). ... all polypropylene. Suitable for one-handed operation. ...
Medicine Products: