Navigation Links
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
Date:8/5/2009

8 was generally safe and well tolerated in this study, with adverse events similar between the BA058 and placebo/Forteo(R) groups. In addition, the occurrence of hypercalcemia was half that of Forteo(R) in the highest dose of BA058 tested. Radius will submit additional detailed results from the Phase 2 study for presentation at an upcoming medical meeting.

"The results of this study affirm BA058's safety and bone-building activity and support its promise as a next-generation anabolic treatment for osteoporosis," said C. Richard Lyttle, PhD, President and CEO of Radius. "We are especially encouraged by BA058's superior efficacy in building new bone rapidly, particularly at the femoral neck, since hip fractures are one of the most serious complications of osteoporosis and an area in which currently available osteoporosis treatments are weak."

"These data are consistent with the clinical hypothesis for BA058--greater gains in BMD at the critical anatomic sites with less resorptive effect and less hypercalcemia compared to PTH and its analogs," said Louis O'Dea, MD, Chief Medical Officer of Radius. "The greater and faster accrual of BMD with BA058 may allow for shorter durations of treatment and a more rapid reduction in fracture risk in the severe osteoporotic postmenopausal population, which would be a significant advance in the treatment of this debilitating disease."

About the Phase 2 Clinical Trial

The Phase 2 randomized, placebo- and comparator-controlled, parallel-group, dose-finding study was conducted in the U.S., Argentina, United Kingdom, and India and was designed to evaluate the safety and efficacy of BA058 in the treatment of otherwise healthy postmenopausal women with osteoporosis. A total of 221 patients were enrolled and treated in the initial six-month period, and 55 patients continued into a subsequent additional six-month treatment period. Patients were on average 65 years old (
'/>"/>

SOURCE Radius
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Radius Completes Enrollment of Phase II Clinical Trial of BA058 for Osteoporosis
2. Radius Selects First Preclinical Candidate From SARM Discovery Program for the Treatment of Muscle Loss and Other Musculoskeletal Conditions
3. Radius Raises Additional $15 Million, Increasing Second Private Equity Financing Round to $82.5 Million
4. Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes
5. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
6. A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol
7. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
8. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
9. Replidynes Investigational Antibacterial Agent REP3123 Prevents Sporulation in Clostridium difficile
10. Replidynes Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile
11. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Inc. (NASDAQ: CYBX ) today announced results for ... highlights 1   Operating results for the first ... fiscal 2014, and other achievements, include: , Worldwide net ... , Strong international net sales of $13.2 million, an increase ... net product sales reached a new high of $58.8 million, ...
(Date:8/21/2014)... 2014 Asterias Biotherapeutics, Inc. (OTCBB: ASTY), a ... medicine, announced today the appointments of Andrew ("Andy") Arno ... Board of Directors. With these additions, the Asterias Board ... are independent. Andy Arno , 55, ... companies. He is currently Managing Director of Emerging Growth ...
(Date:8/20/2014)... HOLBROOK, N.Y. , Aug. 20, 2014 /PRNewswire/ ... MDIN) today announced that after months of hard ... finally finished the new Snorenz formulation and package ... vitamins E and B-6 back into the product ... well as longer lasting effects.  Snorenz Nighttime will ...
Breaking Medicine Technology:Cyberonics Reports Fiscal 2015 First Quarter Results 2Cyberonics Reports Fiscal 2015 First Quarter Results 3Cyberonics Reports Fiscal 2015 First Quarter Results 4Cyberonics Reports Fiscal 2015 First Quarter Results 5Cyberonics Reports Fiscal 2015 First Quarter Results 6Cyberonics Reports Fiscal 2015 First Quarter Results 7Cyberonics Reports Fiscal 2015 First Quarter Results 8Cyberonics Reports Fiscal 2015 First Quarter Results 9Cyberonics Reports Fiscal 2015 First Quarter Results 10Cyberonics Reports Fiscal 2015 First Quarter Results 11Cyberonics Reports Fiscal 2015 First Quarter Results 12Cyberonics Reports Fiscal 2015 First Quarter Results 13Cyberonics Reports Fiscal 2015 First Quarter Results 14Cyberonics Reports Fiscal 2015 First Quarter Results 15Cyberonics Reports Fiscal 2015 First Quarter Results 16Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 3Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 4Northstar completes the first phase of its new retail strategy and prepares to ship reformulated Snorenz with all new packaging 2
... W.Va., June 19 Keeping your teeth brushed and flossed can ... and stroke, dentists have warned for years. Now researchers at ... help preserve memory. , , The National Institutes of Health ... further build on studies linking gum disease and mild to moderate ...
... Florida,s First Three-Year Neuroscience Research Doctorate Program , ... Roskamp Institute (Roskamp) today announced the first enrollment ... through which students will conduct full-time laboratory research ... is an Affiliated Research Centre (ARC) of the ...
Cached Medicine Technology:School of Dentistry Studies Link Between Oral Health and Memory 2Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program 2Roskamp Institute Announces Enrollment of First Students to Participate in its Innovative Research Doctorate Program 3
(Date:8/21/2014)... CO (PRWEB) August 21, 2014 Aspen Advisors, ... been selected as one of Modern Healthcare’s Best Places ... program recognizes employers in the healthcare industry for creating workplaces ... Results are solely based on employee responses to an employee ... year that Aspen has been named a “Best ...
(Date:8/21/2014)... by T-type calcium channels in the thalamic reticular ... calcium. These channels enable thalamic reticular nucleus neurons ... enter a hyper-excited state. , In order to ... seizures, the researchers conducted an experiment to induce ... to delete the T-type calcium channel CaV3.3. The ...
(Date:8/21/2014)... to researchers at the University of Montreal, the regions ... role as we train our bodies, movements and, critically, ... While researchers knew that sleep helped us the learn ... why. "The subcortical regions are important in information consolidation, ... consolidation level is measured after a period of sleep, ...
(Date:8/21/2014)... Bedros Keuilian’s Annual Fitness Business Summit is considered the ... people already earning seven-figure incomes. But his annual Fit ... to the owners of Keuilian’s own international fitness boot camp ... Boot Camp World Conference will also be attended by 50 ... or are struggling with their own boot camp businesses. ...
(Date:8/21/2014)... Hunhu Healthcare, Inc. , a Minneapolis-based ... it has entered into a licensing agreement with Mayo ... predictive analytics for recruiting, leveraging and managing its solution ... Michael Emerson , co-founder and CEO of Hunhu Healthcare, ... technology used in what he calls a social wellness ...
Breaking Medicine News(10 mins):Health News:Modern Healthcare Names Aspen Advisors Among the Top 100 Employers in the Healthcare Industry for a Fourth Consecutive Year 2Health News:Learning to play the piano? Sleep on it! 2Health News:Fitness Boot Camp Founder Offers Fifty Scholarships to Fit Body Boot Camp World Conference 2Health News:Fitness Boot Camp Founder Offers Fifty Scholarships to Fit Body Boot Camp World Conference 3Health News:Hunhu Healthcare Enters into Licensing Agreement with Mayo Clinic 2
... have discovered a second gene that causes Alagille syndrome, ... many organs.// , This finding may have broader ... Hospital team had earlier discovered the first gene associated ... mutations in the NOTCH 2 gene were linked to ...
... 9,000 Danish residents revealed that a specific mutation in the ... breast cancer in her lifetime. The study, which was the ... the cancer risk associated with it, in the general population, ... Journal of Clinical Oncology. ,"Our study shows ...
... University of Georgia have suggested that cross-immunity created in ... protect against infection //,by related serotypes thus leading to ... This finding would help understand the pattern of this ... about the mid 1980s, there's been a sequential replacement ...
... nicotine dependence can develop in some smokers right after ... Smoking cessation programs for teenagers have had little ... the cessation programs aimed at youngsters for the programs ... use has traditionally been thought to progress through 5 ...
... listed on food labels to help cut heart disease, according ... experts putting forward their arguments in this week's British Medical ... combat the UK's number one killer, estimated to be responsible ... ,In addition cardiovascular disease is reported to cost the ...
... medically shocking incident, a 35-year-old woman in Madhya Pradesh survived ... was however operated upon Friday at the government hospital at ... a kilo-and-half was finally removed from her womb. ... menstrual cycle started in the seventh month of her pregnancy, ...
Cached Medicine News:Health News:Second Alagille Syndrome Gene discovered: More information on kidney disease 2Health News:CHEK 2 Gene Mutation Triples Breast Cancer Risk 2Health News:Waxing And Waning Of Dengue Epidemics Attributed To Cross-Immunity 2Health News:Waxing And Waning Of Dengue Epidemics Attributed To Cross-Immunity 3Health News:Scientists Push for Labeling of all Fats to Avoid Heart Disease 2
... Speed Pre and Post High Vacuum Autoclaves. ... designed to cover a large of applications ... well as private clinics and dental offices. ... of medical and surgical materials such as ...
... manual autoclaves set the standard for steam ... to compliment any healthcare and laboratory facility. ... of your sterilization needs. Time tested reliability ... product. The Tuttnauer M Series is also ...
... is a confocal laser scanning microscope ... images of the posterior segment. It ... retinal topography and precise follow-up of ... routine application of Heidelberg Retina Tomograph ...
Subjective refraction unit, computer controlled and programmable. Two versions: with and without prisms....
Medicine Products: