Navigation Links
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
Date:8/5/2009

CAMBRIDGE, Mass., Aug. 5 /PRNewswire/ -- Radius Health ("Radius") today announced topline Phase 2 data demonstrating that in women with osteoporosis, BA058 -- the company's novel PTHrP (parathyroid hormone-related protein) analog -- significantly increased bone mineral density (BMD) at the lumbar spine and femoral neck (a common fracture site located in the hip joint) after six months of therapy. The gains in lumbar spine and femoral neck BMD were further increased in a subset of patients that elected to continue therapy for a total of 12 months of treatment, and at both time points, the changes were greater than those seen with Forteo(R) (teriparatide), the reference drug used in this dose-finding study.

The objective of the 221-patient Phase 2 clinical trial was to assess safety and evaluate the effect of three doses of BA058 on bone formation markers and on lumbar spine and femoral neck BMD over six months relative to placebo. The study also included a Forteo(R) reference arm. Forteo(R), a form of parathyroid hormone, is the only anabolic (bone-building) agent approved for marketing by the U.S. Food and Drug Administration for the treatment of osteoporosis in women and men at high risk of fracture.

BA058 significantly increased mean lumbar spine BMD by 6.7 percent compared with 1.6 percent for placebo and significantly boosted mean femoral neck BMD by 3.1 percent compared with 0.8 percent for placebo at six months for the highest dose tested. By comparison, the mean percent change in the Forteo(R) group for lumbar spine BMD was 5.5 percent, and for femoral neck BMD was 1.1 percent. In the 12-month treatment period, patients receiving the highest dose of BA058 increased lumbar spine BMD by 12.9 percent at 12 months compared with 8.6 percent in the Forteo(R) group and boosted femoral neck BMD by 4.1 percent compared with 2.2 percent for the Forteo(R) group.

BA05
'/>"/>

SOURCE Radius
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Radius Completes Enrollment of Phase II Clinical Trial of BA058 for Osteoporosis
2. Radius Selects First Preclinical Candidate From SARM Discovery Program for the Treatment of Muscle Loss and Other Musculoskeletal Conditions
3. Radius Raises Additional $15 Million, Increasing Second Private Equity Financing Round to $82.5 Million
4. Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes
5. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
6. A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol
7. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
8. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
9. Replidynes Investigational Antibacterial Agent REP3123 Prevents Sporulation in Clostridium difficile
10. Replidynes Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile
11. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... and RALEIGH, N.C. , Dec. ... Endo International plc (NASDAQ: ENDP ) (TSX: ... BDSI ) announced today that they have submitted a ... to the U.S. Food and Drug Administration (FDA).  Buprenorphine ... of pain severe enough to require daily, around-the-clock, long-term ...
(Date:12/22/2014)... , Dec. 22, 2014 Apnea Sciences ... corporate offices in Aliso Viejo , ... due to the tremendous growth and worldwide expansion, a ... of patented SnoreRx, the anti snore cure have exceeded ... said, "We are now in 23 countries and ...
(Date:12/22/2014)... -- ConvaTec, a privately-held medical products and technologies company, today ... Executive Officer of the company, effective December 22, 2014. ... "The Board of Directors of ConvaTec thanks Mr. Berger ... three years," said Magnus Lundberg , the Chairman ... the company is well positioned for the future."  The ...
Breaking Medicine Technology:Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 2Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 3Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 4Endo Pharmaceuticals and BioDelivery Sciences Announce NDA Submission for Buprenorphine HCl Buccal Film for the Management of Moderate to Severe Chronic Pain 5ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2
... 1, 2011 Haemonetics Corporation (NYSE: HAE ... and full year of its 2011 fiscal year and ... 2, 2011 in a pre-market press release.  The Company ... about the press release at 10:00 am (EDT) on ...
... working on the quality and range of services offered, giving ... time they come back. This time, the pharmacy has offered ... receive a 5% discount when buying Viagra or Cialis online. ... two months, starting from April 1. The pharmacy expressed its ...
Cached Medicine Technology:Web Pharmacy Rxbuys.com Gives Its Customers a 5% Discount Coupon 2
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... highlight top beauty and wellness ... making a difference, NEW YORK, April 7, 2008 ... an educational conference for,media and industry insiders in the beauty ... first public awareness campaign,"Go With Your Own Glow.", On ...
... 7, 2008 EntreMed, Inc.,(Nasdaq: ENMD ), ... of cancer and inflammatory diseases, today,announced the retirement ... 5, 2008., (Logo: http://www.newscom.com/cgi-bin/prnh/20010620/ENMDLOGO ), ... EntreMed since 2003, and has been,instrumental in helping ...
... Forest Laboratories,Inc. (NYSE: FRX ), an ... its Fiscal 2008 Fourth Quarter,financial results before the ... Later that day, at 10:00 AM EDT, Forest ... President and Chief Operating Officer and Frank,Perier, Senior ...
... Out of Business and,Disrupt Services to as Many as ... Beaumont, El Paso, Houston, McAllen, and San Antonio Are ... new Medicare,bidding program for durable medical equipment (DME) scheduled ... July 1, 2008, will,put many DME providers out of ...
... of whom have multiple chronic illnesses face severe ... to avert pending cuts to Medicare payments, according to ... released today by the 125,000-member American College of Physicians ... on access-to-care were evident from the responses of almost ...
... X-Ray Rooms from Film to IDC Digital ... ... (Imaging Dynamics Company,Ltd.) (TSX: IDL), the global leader in the rapidly ... New York has purchased IDC,s X2200, X1590, and X1600 Plus direct,digital ...
Cached Medicine News:Health News:5W Public Relations Presents the 2008 Body Beautiful Media Symposium Benefiting The Skin Cancer Foundation 2Health News:5W Public Relations Presents the 2008 Body Beautiful Media Symposium Benefiting The Skin Cancer Foundation 3Health News:Dr. Ronald E. Cape to Retire from EntreMed Board of Directors 2Health News:Dr. Ronald E. Cape to Retire from EntreMed Board of Directors 3Health News:Forest Laboratories, Inc. Sets Date and Conference Call for Fiscal 2008 Fourth Quarter Earnings 2Health News:Medicare Bidding Program for Dallas, Texas is Rife with Errors, Says American Association for Homecare 2Health News:Medicare Bidding Program for Dallas, Texas is Rife with Errors, Says American Association for Homecare 3Health News:ACP reports on how scheduled Medicare pay cuts will affect patients 2Health News:ACP reports on how scheduled Medicare pay cuts will affect patients 3Health News:Saratoga Hospital Purchases Three IDC DR Systems 2Health News:Saratoga Hospital Purchases Three IDC DR Systems 3
Electric Reciprocating Saw, with hand throttle. Can also be purchased without hand throttle (#1915) for use with foot pedal. (#6401-000)...
... Micro Sagittal Saw, without hand ... arc. Head rotates 360 deg. ... and our unique blade locking ... be used with foot throttle ...
... Electric Micro Sagittal Saw, with ... deg. arc. Head rotates 360 ... angle, and our unique blade ... Can also be purchased without ...
... Brasseler USA™ Battery Tester ... and efficiently determine if ... STR-3000 Extended Run, Stryker® ... Battery Packs contain adequate ...
Medicine Products: