Navigation Links
RXi Pharmaceuticals Announces mRNA Data of an Additional Cohort in the Second Phase 1 Multi-Dose Study with RXI-109, Extending the Dose Response Following Treatment in the Initial 2-week Period
Date:12/4/2013

RNA reduction.  Both treatment regimens were safe and well tolerated.  However, delay of dosing resulted in fewer local skin effects for both placebo and active.    

Based on the excellent safety profile shown in Phase 1, a Phase 2 study was initiated in November 2013 in which subjects will receive multiple doses of RXI-109 in conjunction with revision surgery on existing hypertrophic scars. Additional studies in hypertrophic scars and keloids are planned.  

Dr. Geert Cauwenbergh, President and CEO of RXi Pharmaceuticals said that, "We are pleased with the outcome of our completed second Phase 1 study.  The results show that multiple intradermal injections of RXI‑109 are well tolerated with minimal and mild side effects". He added that, "The addition of a 4th cohort at a higher dose has confirmed the dose related suppression of CTGF mRNA when RXI-109 is administered shortly after the surgical incisions are made, with 50% reduction with the highest dose compared to 9%, 43% and 43% reduction of CTGF mRNA  for the 2.5, 5, and 7.5 mg doses, respectively. The fact that the already mild side effect profile observed with the drug seems to be even lower when the treatment is delayed for two weeks after the incisions, supports our decision to have immediate and delayed treatment groups included in our ongoing Phases 2 study for treatment of pre-existing hypertrophic scars in the lower abdominal area".

About RXi Pharmaceuticals Corporation

RXi Pharmaceuticals Corporation (OTCQX: RXII) is a biotechnology company focused on discovering, developing and commercializing innovative therapies based on its proprietary, self-delivering RNAi platform. Therapeutics that use RNA interference, or "RNAi," have great  promise because of their ability to down-regulate, the expression of a specific gene that may be over-expressed in a disease condition. Building o
'/>"/>

SOURCE RXi Pharmaceuticals Corporation
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Savient Pharmaceuticals to Hold First Quarter 2012 Financial Results Conference Call on Wednesday, May 9, 2012
2. Auxilium Pharmaceuticals to Present at the Deutsche Bank 37th Annual Healthcare Conference
3. Nouveau Life Pharmaceuticals (HRID) Contracts with U.S. Manufacturer to Produce New Female Supplement
4. BioElectronics Survey Indicates a Five-Fold Superior Pain Relief Compared to OTC Pharmaceuticals
5. Icahn Issues Statement Regarding Amylin Pharmaceuticals
6. Almost 50 Percent of the Glaucoma Patient Population Remains Untreated, Signifying a Vast Market for Glaucoma Pharmaceuticals, Finds Frost & Sullivan
7. Omthera Pharmaceuticals Announces Positive Top-Line Results from Phase 3 EVOLVE Study
8. Onyx Pharmaceuticals Announces FDA Advisory Committee to Review Carfilzomib for the Treatment of Patients with Relapsed and Refractory Multiple Myeloma
9. Jazz Pharmaceuticals Announces First Quarter 2012 Financial Results Conference Call On May 8, 2012
10. Inovio Pharmaceuticals Granted U.S. Patent Protection for Synthetic Vaccine for Cervical Dysplasia and Cancer
11. Avanir Pharmaceuticals To Present at Three Conferences In May
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... Mass. , Oct. 30, 2014 Boston ... to participate in the 2014 Credit Suisse Annual Healthcare ... Phoenix , AZ.  Dan Brennan , executive ... presentation about the company beginning at approximately 8:00 a.m. ... A live webcast of the presentation and question ...
(Date:10/30/2014)... , Oct. 30, 2014   ViaDerma, ... devoted to bringing new products to market, has ... called TetraStem. TetraStem is a topical liquid tetracycline-based ... system that can convert oral medication active ingredients ... as a first aid antibiotic to help prevent ...
(Date:10/30/2014)... , Oct. 30, 2014 CVS Health (NYSE: ... new clinical affiliations with three leading regional health systems to ... The collaborating health systems include Baptist Health System in ... which include Commonwealth Health in Pennsylvania , ... Arizona , and Tennova Healthcare in Tennessee ...
Breaking Medicine Technology:Boston Scientific To Participate In 2014 Credit Suisse Annual Healthcare Conference 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 2ViaDerma, Inc. Lead Product TetraStem Shown Effective in Fighting Staph Infections including MRSA 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 2CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 3CVS Health Announces New Clinical Affiliations with Leading Regional Health Systems 4
(Date:10/30/2014)... Five months after their expansion, the ... announces new branding and a website to accompany their ... David Mepham’s promotion to name partner earlier this year, ... include Mepham’s name and better reflect their combined litigation ... the decision to implement new branding reflects Hodgkinson Street ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. 29, ... prostate cancer who also have certain heart problems may increase ... study suggests. , , The therapy in question is called androgen ... levels of male hormones to prevent the growth of cancer ... this hormone therapy was linked to triple the risk of ...
(Date:10/30/2014)... IL (PRWEB) October 30, 2014 Dr. Joseph ... a new website for his practices; OB GYN in ... IL . This website contains important information about each ... as well as downloadable patient forms in English and Spanish. ... and the service pages on the website provide Dr. Furlin’s ...
(Date:10/30/2014)... REV'D Provision Co. announced today that REV’D® ... unique service called, The Feed . The Feed ... athlete. The Feed has taken the nutritional knowledge used ... to pass that information on to the everyday athlete. ... on The Feed!” says REV’D® marketing manager Matt O’Connor. ...
(Date:10/30/2014)... Sound Telecom, a leader in the call center industry, just ... they wonder, “Should I use an answering service?” The graphic ... a series of yes or no questions that ultimately ends ... many considerations and scenarios that come into play when deciding ... This decision infographic serves as a bit of a map ...
Breaking Medicine News(10 mins):Health News:Hodgkinson Street Mepham Rebrands 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Dr. Joseph Furlin Launches New Website with Information about Care Services 2Health News:Nutrition Experts at TheFeed.com Get REV'D 2Health News:Nutrition Experts at TheFeed.com Get REV'D 3Health News:Sound Telecom Produces Decision Infographic to Aid Businesses 2
... TAMPA, Fla., Sept. 1 Amazing medical advancements are made ... been before. As a result, people are living longer lives. While ... population and new medical discoveries has created a huge demand for ... -- from one-year Licensed Practical Nurse (LPN) certifications ...
... September 1, 2009Patients with advanced illnesses more than doubled ... health plan made hospice care more readily accessible, according ... Journal of Palliative Medicine , a peer-reviewed publication ... of Palliative Medicine is the official journal of ...
... a myriad of diseases, including cancer, heart disease and ... for delivering genes to cells both efficiently and safely ... University researchers has introduced the power of nanodiamonds as ... in one approach: enhanced delivery efficiency along with outstanding ...
... , , CHICAGO, Sept. ... "Project Runway," launched a new online video series, called " Living ... national HIV and AIDS education initiative. The Living Positive By ... videos aim to encourage thoughtful conversations about HIV and AIDS, to ...
... , BOSTON, Sept. 1 AMR ... supply chain and its supporting technologies, is proud to announce that ... research for the firm, was named to PharmaVOICE,s list of the ... , , According to PharmaVOICE,s July/August edition, "One ...
... CINCINNATI, Sept. 1 Healthy Advice ... patient-education programs has announced that SIGVARIS, the world,s leading ... the Skin Care Network to broaden their educational coverage. ... an ideal place to increase the awareness of Chronic ...
Cached Medicine News:Health News:Saving Lives Is a Growth Industry 2Health News:Saving Lives Is a Growth Industry 3Health News:Expanded insurance benefits break down barriers to hospice care, according to new study 2Health News:Promise of nanodiamonds for safer gene therapy 2Health News:Promise of nanodiamonds for safer gene therapy 3Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 2Health News:Video: 'Project Runway' Designer Launches New Online Video Series to Educate About Living with HIV and AIDS and Help Combat HIV Stigma 3Health News:AMR Research Analyst Named One of the Most Inspiring Individuals in Life Sciences by PharmaVOICE 2Health News:AMR Research Analyst Named One of the Most Inspiring Individuals in Life Sciences by PharmaVOICE 3Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 2Health News:SIGVARIS USA Extends Educational Efforts in Healthy Advice's Skin Care Network 3
Lightweight Pneumatic Conserver., ,NOTE: All models passed the ASTM PS 127-00 regulator ignition safety test....
... ,Offers an average 5:1 increase in usage ... use of a standard cannula. , ,The ... offers ambulatory oxygen patients a superior alternative to ... 2-year warranty. , ...
Redesigning the World's Oxygen Therapy One Device at a Time. , ,Everything you like about our OXYMATIC 400 Series conservers, only better!...
Includes conservation device, matched regulator, standard supply tubing, cannula, carrying case, batteries, and instruction booklet....
Medicine Products: