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RMANJ Research Demonstrates That Egg Freezing Prior To IVF Yields Positive Outcomes Without Increasing Risk Of Aneuploidy
Date:9/12/2012

care are enormous."

In an accompanying editorial, Ana Cobo, Ph.D., a leader in oocyte vitrification in Europe, concluded that with this study, a "Watershed in ART" has been reached, opening a new window of hope for the growing population of female cancer survivors and for women whose career choices challenge their biological clocks.  In the editorial Dr. Cobo emphasized the power and value of this landmark study: The evidence that aneuploidy is not increased in vitrified oocytes is a welcome endorsement of the safety of the vitrification technique and constitutes a giant step toward its definitive validation as a strategy for fertility treatment.

About the Study

The paired, randomized controlled trial was designed to assess the impact of oocyte vitrification on aneuploidy and reproductive potential by comparing vitrified and control oocytes from a single patient within a single cycle and a single fresh transfer.  The study included forty-four patients with a mean age of 29.9 +/- 2.3 years and normal ovarian reserve. 

The primary outcome measure was the rate of aneuploidy.  Additional outcome measures included: fertilization, cleavage, blastulation, and implantation in embryos derived from vitrified and control oocytes.

A total of 588 mature oocytes were randomized, with 240/294 (81.6%) surviving vitrification.  Among surviving vitrified oocytes, there was no difference in the rate of embryonic aneuploidy (vitrified, 29.1% vs. control, 26.4%).  In paired blastocyst transfers, the ongoing pregnancy rate per embryo was comparable (vitrified, 53.9% vs. control, 57.7%).  There were differences noted in embryonic development. There was a lower fertilization rate with intracytoplasmic sperm injection (77.9% vs. 90.5%), a lower cleavage rate (90.9% vs. 99.2%), and a lower usable blastocyst formation rate per two pronuclei (34.8% vs. 50.8%).1 The authors noted that while there were diff
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SOURCE Reproductive Medicine Associates of New Jersey
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