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REVEAL(R) RegistryData May Advance Patient Care in Pulmonary Arterial Hypertension
Date:5/17/2010

pathways (the prostacyclin pathway; the endothelin pathway; and the nitric oxide pathway) [2]. The available therapies have shown positive treatment effects in patients with PAH, but they do not provide a cure, and in many patients the disease will progress. PAH remains a serious life-threatening condition [2,3]. Early recognition and an understanding of the selection and timing of therapeutic options remain critical elements in the optimal management of PAH patients.

References

1. Farber HW; Loscalzo J. Mechanisms of disease: pulmonary arterial hypertension. N. Eng. J. Med. 2004; 351:1655-65.

2. Humbert M; Sitbon O; Simonneau G. Treatment of pulmonary arterial hypertension. N. Eng. J. Med. 2004;351:1425-36.

3. Humbert M; Morrell NW; Archer SL; et al. Cellular and molecular pathobiology of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 2004; 43: Suppl. 12: 13S-24S. 

About the REVEAL® Registry

The REVEAL Registry is a multi-center, observational, U.S.-based study of the clinical course and disease management of patients with PAH. Approximately 3,500 previously and newly diagnosed patients from over 50 participating centers across the United States have been enrolled and tracked in the REVEAL Registry. Patients are followed for a minimum of five years from the time of enrollment. The registry has enrolled consenting newly diagnosed or previously diagnosed patients with World Health Organization (WHO) Group I PAH, who meet specific hemodynamic criteria based upon prior performance of right heart catheterization. The REVEAL Registry is sponsored by Actelion Pharmaceuticals. For more information, please visit

SOURCE Actelion Ltd
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