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REVEAL(R) RegistryData May Advance Patient Care in Pulmonary Arterial Hypertension
Date:5/17/2010

and functional class, that together predict 1-year survival. The final model was simplified into a risk score of 1-15 and tested in 398 newly diagnosed PAH patients.  The 1-year survival of this cohort of patients with risk scores of 1 to 5 was 99.1%; 6 to 7 was 95.5%; 8 to 9 was 91.1%; 10 to 11 was 79.1%; and 12 to 15 was 50.4%.

About "Refining Definitions of Time to Clinical Worsening in Connective Tissue Disease Associated with PAH (CTD-PAH)

A second presentation today demonstrated that data from the REVEAL Registry may improve physicians' ability to determine the prognosis of patients with connective tissue disease associated pulmonary arterial hypertension (CTD-APAH). The study led by Roham T. Zamanian, M.D., Division of Pulmonary & Critical Care Medicine, Stanford University Medical Center, Stanford, Calif., found that current parameters that include all-cause hospitalization and addition of IV/SC prostacyclin therapies may not be appropriate for defining time to clinical worsening (TTCW) for patients with CTD-APAH.

The analysis included 586 newly diagnosed idiopathic PAH and CTD-APAH patients with a median follow up of 15 months, and compared two definitions of TTCW: major event, worsening functional class, or 15% reduction in 6-minute walk test versus major event, worsening functional class, 15% reduction in 6-minute walk test, all-cause hospitalization, or addition of IV/SC prostacyclin for any reason. Results showed TTCW defined by the first criteria predicted the worst outcomes in CTD-APAH patients, but when all-cause hospitalization and addition of prostacyclin therapies were added the predictive value of the model was no longer statistically significant.

Additional Data at ATS

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SOURCE Actelion Ltd
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