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RADIESSE More Effective Than Restylane As Reported In a 60-Patient Clinical Trial
Date:1/14/2008

ved through a 12-month period (9 months following the second treatment).

The results of the study demonstrated that upon evaluation as measured by the Global Aesthetic Improvement Score (GAIS), a greater number of folds treated with RADIESSE dermal filler were rated as "improved" or better at six and nine months following treatment, as compared to the number of "improved" or better Restylane folds. At nine months following second treatment, 79% of folds treated with RADIESSE filler and 43% of folds treated with Restylane filler showed improvement as measured by the GAIS (p<0.0001). The blinded evaluators also determined that in nearly 47% of patients the RADIESSE-treated folds were more improved than the Restylane-treated folds, while only 5% of patients had Restylane folds more improved (p<0.0001).

The results of the Wrinkle Severity Rating System (WSRS) evaluation showed a greater average improvement in RADIESSE-treated folds as compared to Restylane-treated folds at three, six and nine months following the second treatment. On the patient preference evaluation, at each time point more than 60% of patients preferred the RADIESSE fold (p<0.05) to the Restylane fold. In addition, RADIESSE filler required significantly less material to achieve full correction, with an average total injection volume of 0.88cc in contrast to Restylane which needed an average of 1.26cc (p<0.001).

This study was conducted as a post-approval comparison of two leading fillers, and was not intended to support regulatory approval. This study has been accepted for peer-reviewed publication in the Journal of Dermatologic Surgery and will be published in the February 2008 issue.

About BioForm Medical, Inc.:

BioForm Medical, Inc. is a medical aesthetics company headquartered in San Mateo, California. BioForm Medical is dedicated to bringing doctors and their patients safe and effective products for use in the dermatology, plastic surgery and ENT markets. BioFor
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SOURCE BioForm Medical, Inc.
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