Navigation Links
RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial
Date:12/12/2008

ents had stable disease and two patients had progressive disease. The critical dose-limiting toxicities (i.e., dose-limiting toxicities in cycle 1) occurring in the 5 mg daily treatment group included grade 3/4 neutropenia, grade 3 stomatitis, grade 3 fatigue and grade 3 anorexia. In the 30 mg weekly treatment group, grade 3/4 neutropenia was the only critical dose-limiting toxicity. There were no critical dose-limiting toxicities in the 20 mg weekly RAD001 treatment arm. The most commonly reported grade 3/4 adverse events (greater than or equal to 10%) suspected of being related to study treatment were neutropenia, stomatitis and leukopenia.

About breast cancer

In the US, invasive breast cancer affects one in eight women. It is the second most common cancer among women in the US and the second leading cause of cancer-related death in women. Breast cancer is expected to claim the lives of approximately 40,500 women in 2008.

Inside a breast there are many lobes, ducts and vessels that support several important functions in the body, including reproductive needs and fighting infection. In breast cancer, some of the cells in the breast begin growing abnormally and divide more rapidly than healthy cells. The quick division of cells may cause spreading through the breast, to the lymph nodes or to other parts of the body.

About RAD001

RAD001, an oral once-daily inhibitor of mTOR, is an investigational drug being studied in multiple tumor types. In cancer cells, RAD001 provides continuous inhibition of mTOR, a protein that acts as a central regulator of tumor cell division, cell metabolism and blood vessel growth.

The safety and efficacy profile of RAD001 has not yet been established in oncology and there is no guarantee that RAD001 will become commercially available for oncology indications. The active ingredient in RAD001 is everolimus. The active ingredient everol
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Latest RAD001 Study Results Show Further Increase in Time Without Tumor Growth in Patients With Advanced Kidney Cancer
2. RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors
3. RAD001 Granted Priority Review in the US Based on Potential to Fill Unmet Medical Need in Patients With Advanced Kidney Cancer
4. Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments
5. RAD001 More Than Doubles Time Without Tumor Growth After Failure of Standard Treatment in Patients With Advanced Kidney Cancer
6. Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy
7. New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia
8. Study Shows ACCU-CHEK(R) Blood Glucose Monitoring Systems and Lancing Devices Are Least Painful
9. Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows
10. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
11. Soft Contact Lenses Do Not Lead to Myopic Creep in Children, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... Aug. 4, 2015   The Intellectual Property ... world,s leading provider of intelligent information for businesses ... 2015 CMR Pharmaceutical R&D Factbook , the biopharmaceutical ... concerns around declines in R&D, the analysis identifies ... trillion milestone and forecasts sales to reach $1.3 ...
(Date:8/3/2015)... Utah , Aug. 3, 2015  BC Technical, the ... acquired Ohio Valley Medical Systems, one of the largest ...  The addition of Ohio Valley Medical Systems allows BC ... include Hitachi MRI.   "We couldn,t be ... , President and CEO of BC Technical. "The Ohio ...
(Date:8/3/2015)... GLENWOOD, Ill. , Aug. 3, 2015  Landauer, ... personal and environmental radiation measurement and monitoring, outsourced medical ... announced it will release financial results for the fiscal ... August 10, 2015. The Company will ... August 11, 2015 at 9:00 a.m. Central Time (10:00 ...
Breaking Medicine Technology:Pharma Sales to Grow Beyond $1 Trillion 2BC Technical Acquires Ohio Valley Medical Systems 2Landauer, Inc. Announces Date And Time For Announcement Of Fiscal Third Quarter 2015 Results And Conference Call 2
... 2010 Unilife Corporation ( Unilife or ... that it has completed the A$23.1 million private placement ( Placement ... Unilife issued 27,228,143 CHESS Depositary Interests ( CDIs ) ( ... representing an interest in one sixth of a share of the ...
... InfraReDx, Inc. , a medical device company developing ... E. Muller, M.D., founder and chief executive officer, will ... Diabetes & Obesity Conference, to be held December 7-8, ... The InfraReDx presentation is scheduled to take ...
Cached Medicine Technology:Unilife Completes A$23.1 Million Private Placement 2Unilife Completes A$23.1 Million Private Placement 3Unilife Completes A$23.1 Million Private Placement 4Unilife Completes A$23.1 Million Private Placement 5
(Date:8/3/2015)... , ... August 03, 2015 , ... Sutter Health’s California ... operating officer (COO) at CPMC. Hamila will start in her role effective immediately and ... , Kownacki has worked at CPMC and Sutter Health for about 15 years, including ...
(Date:8/3/2015)... ... August 03, 2015 , ... The Workgroup for Electronic ... health IT to create efficiencies in healthcare information exchange, announced the release of its ... Health and Human Services (HHS) Secretary, WEDI shared survey results and ...
(Date:8/3/2015)... ... 03, 2015 , ... Kantor & Kantor, LLP announced today ... client Rebecca Hamsher, deciding that in accordance with ERISA ( Employee Retirement Income ... treatment for bulimia, depression and other mental health problems. , According to the ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... ... Health notes that while an overwhelming number of Hispanics believe people can ... The overwhelming 70 percent of participants queried said making diet changes was important. ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... its industry-defining contract lifecycle management solution, as well as announced the date of ... the speed and ease of contract management tasks as well as enhancements to ...
Breaking Medicine News(10 mins):Health News:Hamila Kownacki, RN Appointed as New Chief Operating Officer at CPMC 2Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 2Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 3Health News:WEDI ICD-10 Survey Results: Industry Nearing Readiness but Physician Practices Lagging Behind 4Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 2Health News:Kantor & Kantor Announces North Cypress Medical Center Must Reimburse Benefits for Mental Health Treatment 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 2Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 3Health News:Hispanics More Likely to Struggle with Misinformation About Diabetes 4Health News:Novatus Unveils Milestone Software Release 2
... Feb. 6 MaxCyte, Inc., a,clinical-stage therapeutics company ... Douglas Doerfler, President & CEO, will be,presenting at ... York,Waldorf=Astoria, on Monday, February 11, 2008 at 11:45AM., ... overview and discuss the,company,s preclinical and clinical product ...
... of nevirapine greatly reduced infant infections in Africa, ... News) -- The antiretroviral drug nevirapine greatly reduces ... virus to their babies during breast-feeding, according to ... Nevirapine is already in widespread use in developing ...
... Introduces World,s First Collaborative Platform to Integrate, ... WAYLAND, Mass., Feb. 6 Tourtellotte ... for the bio-pharmaceutical industry, is,pleased to announce ... document,management and collaboration platform for complex document ...
... Inc. (Amex:,UPI), a medical device company that develops, ... of voiding dysfunction,announced today that it will be ... on Wednesday, February 20, 2008 at the Ritz ... and Medi Jiwani,Uroplasty,s Vice President and CFO, will ...
... PHILADELPHIA, Feb. 6 The much,anticipated launch ... eToims(R),Soft Tissue Comfort Center, LLC, a University ... Intramuscular,Stimulation (eToims(R) Twitch Relief Method). The site ... including back pain (the second most,common neurological ...
... well as standard, invasive method , , TUESDAY, Feb. 5 (HealthDay ... cancer has spread may be better than traditional, invasive procedures. ... of the Journal of the American Medical Association , ... era for people with lung cancer or suspected lung cancer. ...
Cached Medicine News:Health News:Drug Helps Prevent Breast-Feeding Moms From Passing on HIV 2Health News:Tourtellotte Solutions' Fusion DMC(TM) Unifies the World of Bio-Pharma Documents 2Health News:StopMusclePain.com Launched as Only Website Dedicated to Reversing Back Pain 2Health News:Less Invasive Way to Stage Lung Cancer Shows Promise 2Health News:Less Invasive Way to Stage Lung Cancer Shows Promise 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: