Navigation Links
RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial
Date:12/12/2008

ents had stable disease and two patients had progressive disease. The critical dose-limiting toxicities (i.e., dose-limiting toxicities in cycle 1) occurring in the 5 mg daily treatment group included grade 3/4 neutropenia, grade 3 stomatitis, grade 3 fatigue and grade 3 anorexia. In the 30 mg weekly treatment group, grade 3/4 neutropenia was the only critical dose-limiting toxicity. There were no critical dose-limiting toxicities in the 20 mg weekly RAD001 treatment arm. The most commonly reported grade 3/4 adverse events (greater than or equal to 10%) suspected of being related to study treatment were neutropenia, stomatitis and leukopenia.

About breast cancer

In the US, invasive breast cancer affects one in eight women. It is the second most common cancer among women in the US and the second leading cause of cancer-related death in women. Breast cancer is expected to claim the lives of approximately 40,500 women in 2008.

Inside a breast there are many lobes, ducts and vessels that support several important functions in the body, including reproductive needs and fighting infection. In breast cancer, some of the cells in the breast begin growing abnormally and divide more rapidly than healthy cells. The quick division of cells may cause spreading through the breast, to the lymph nodes or to other parts of the body.

About RAD001

RAD001, an oral once-daily inhibitor of mTOR, is an investigational drug being studied in multiple tumor types. In cancer cells, RAD001 provides continuous inhibition of mTOR, a protein that acts as a central regulator of tumor cell division, cell metabolism and blood vessel growth.

The safety and efficacy profile of RAD001 has not yet been established in oncology and there is no guarantee that RAD001 will become commercially available for oncology indications. The active ingredient in RAD001 is everolimus. The active ingredient everol
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Latest RAD001 Study Results Show Further Increase in Time Without Tumor Growth in Patients With Advanced Kidney Cancer
2. RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors
3. RAD001 Granted Priority Review in the US Based on Potential to Fill Unmet Medical Need in Patients With Advanced Kidney Cancer
4. Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments
5. RAD001 More Than Doubles Time Without Tumor Growth After Failure of Standard Treatment in Patients With Advanced Kidney Cancer
6. Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy
7. New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia
8. Study Shows ACCU-CHEK(R) Blood Glucose Monitoring Systems and Lancing Devices Are Least Painful
9. Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows
10. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
11. Soft Contact Lenses Do Not Lead to Myopic Creep in Children, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... , July 31, 2014 Astellas ... head of corporate and employee communications in the ... Jeff Winton , senior vice president, chief communications ... for developing and leading corporate brand initiatives and ... across North and South America ...
(Date:7/31/2014)... -- Cryoport, Inc. (OTCBB: CYRX) today announced financial results ... Recent Operating Highlights , Achieved ... month period ended June 30, 2014 compared to the ... further expand Cryoport,s global reach using the ,powered by ... Immudex, an immunotherapy and vaccine development services company, to ...
(Date:7/31/2014)... 2014 Nutrastar International Inc. (OTCQB: NUIN; "Nutrastar" ... premium branded consumer products, including commercially cultivated Cordyceps Militaris ... announced the signing of its first distributor for its ... Hubei Province located ... . The contract with the ...
Breaking Medicine Technology:Astellas Hires Industry Veteran Moyra Knight as Head of Corporate and Employee Communications 2Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 2Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 3Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 4Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 5Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 6Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 7Cryoport Reports 92% Revenue Growth for First Quarter of Fiscal 2015 8Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 2Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 3Nutrastar Signs First Distributor for New Cordyceps Powder Solution Product, Expands Reach to Central China 4
... Confirm Robust Efficacy of CIMZIA, BOSTON, Nov. ... new,Phase III data from the RAPID 1 and ... Annual Scientific Meeting (ACR), which show,CIMZIA(R) (certolizumab pegol), ... Factor), given with methotrexate, is significantly,more effective than ...
... Fla., Nov. 7 A new analysis,presented today ... Evaluation Of Rosuvastatin) showed CRESTOR(R) (rosuvastatin calcium) 40,mg ... in four,patient populations at varying levels of risk ... subjects defined by the Framingham risk,assessment tool as ...
Cached Medicine Technology:CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 2CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 3CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 4CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 5CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 6CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 7CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year 8New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease 2New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease 3New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease 4New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease 5New Analysis of METEOR Study Demonstrate Effects of AstraZeneca's CRESTOR(R) (Rosuvastatin Calcium) on Atherosclerosis in Patients With Two or More Risk Factors for Cardiovascular Disease 6
(Date:7/31/2014)... Ethane Web Technologies, an ISO ... new service named ‘Java Development’. The service cost ... designed the service after doing a serious study ... service being provided by other web development companies. ... promise outstanding Java Development service. ...
(Date:7/31/2014)... for anyone, but for those with periodontal disease related to ... smiling. In a report appearing in the August 2014 issue ... one of the most important blood cells involved in the ... and bone loss in type 2 diabetes-associated periodontal disease. ... responses of B cells may treat or prevent this complication. ...
(Date:7/31/2014)... 2014 Healthpointe Medical Group, one ... maintaining the highest standards in health and safety ... is offering Occupational Medicine Services at ... patients. They also accept workers’ compensation cases and ... Medicine services include, but are not limited to, ...
(Date:7/31/2014)... 31, 2014 FORT LAUDERDALE, FLORIDA ... a leading US Joint Commission Accredited teleradiology and ... and technologically advanced consumer storage and sharing platform ... is providing valued members the use of its ... services already offered by SecondOpinions.com®. , Wide-spread ...
(Date:7/31/2014)... New York, NY (PRWEB) July 31, 2014 ... will host its first-ever event in New York on ... Eventi Hotel in Manhattan. , Featuring keynotes by ... Assemblyman Steve Katz (R-Yorktown), the event will include lunch ... Compassionate Care Act and the work NCIA is doing ...
Breaking Medicine News(10 mins):Health News:Ethane Web Technologies Announces Java Development Service at Pocket Friendly Cost 2Health News:Researchers uncover cause of gum disease related to type 2 diabetes 2Health News:Occupational Medicine Services Available at Healthpointe’s Perris Facility 2Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 2Health News:SECONDOPINIONS.COM® Introduces Innovative Cloud-Based Medical Imaging Exchange Service for Easy Upload, Access and Sharing Anytime/Anywhere 3Health News:THURSDAY, AUG 7: First-Ever National Cannabis Industry Association Event in New York Will Feature Senator Savino, Assemblyman Katz, & Industry Leaders 2
... ... v 2.0 which is made up of three products: Semantics.Datacenter, Semantics.Server, and Semantics.Framework. ... industry standard benchmark tests (Berlin 100M 5/25/10). , ... Brattleboro, VT (PRWEB) June 17, 2010 -- ...
... ... Service; Simplicity, Security Benefits IP Telephony Implementation , ... Mississauga, Ontario (PRWEB) June 17, 2010 -- Phybridge ... compliant with key IP Telephony solutions from Avaya, a leading global provider of business ...
... ... a house boating trip at Sunset Marina and Resort. Beautiful Dale Hollow Lake offers ... of Tennessee. , ... Byrdstown, TN (PRWEB) June 17, 2010 -- Families are flocking to the hills of ...
... ... a weekly blog column about Internet Marketing. Paul Hannam will write about hot topics such ... practical strategies and case studies. , ... (PRWEB) June 17, 2010 -- San Diego-based Bright Green Leadership LLC, ...
... ... Website And Updated Web Hosting Plans That Provide The Resources And Services Needed To ... ... our customer in mind, Hosting Metro is proud to announce the launch of their ...
... ... Community Baby Shower for Philadelphia Mothers-to-be , ... Philadelphia, Pa. (Vocus) June 16, 2010 -- Keystone Mercy Health ... Family Services, Inc., a non-profit organization that provides health services to families, will host ...
Cached Medicine News:Health News:Intellidimension Releases New Version of Semantic Web Technologies 2Health News:Phybridge Network Solution Achieves Avaya “Compliant” Status 2Health News:Phybridge Network Solution Achieves Avaya “Compliant” Status 3Health News:Sunset Marina and Resort on Tennessee's Dale Hollow Lake Provides Affordable Houseboat Vacations for Price-Conscious Families 2Health News:Bright Green Leadership Partners with TriplePundit to Help Businesses Improve Their Green Marketing Online 2Health News:Hosting Metro Releases New Website and Upgraded Pricing Plans For All Web Hosting Packages 2Health News:Hosting Metro Releases New Website and Upgraded Pricing Plans For All Web Hosting Packages 3Health News:More Than 100 Philadelphia Expectant-Mothers and Their Families to Attend Keystone Mercy Health Plan's Community Baby Shower 2
... ventricular drainage set (EVD set) ... for external ventricular drainage. It ... with a ventricular catheter or ... probe from the Aesculap Spiegelberg ...
... The Trippi-Wells and Universal tongs were ... are needed than can be safely provided ... ring. Titanium construction. Kit complete with four ... or four pin application. Skull pins at ...
... neuro and skull base surgery. Complete ... surgery, pediatric neurosurgery, bony defects of ... base regions, neuro trauma. Dedicated neuro/skull ... in one compact kit. MRI and ...
Hand Drill, with two-position Handle, with Jacob three-jaw chuck, wrench-locked for changing twist drills up to 6 mm...
Medicine Products: