Navigation Links
RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial
Date:12/12/2008

a partial response, six patients had stable disease and one patient had progressive disease. Among the nine patients evaluated in the 30 mg weekly treatment arm, three patients had partial responses, five patients had stable disease and one patient had progressive disease. The critical dose- limiting toxicities occurring in the first cycle of treatment included febrile neutropenia, oral mucositis and confusion occurring in the 5 mg daily, 10 mg daily and 30 mg weekly treatment groups, respectively. The most commonly reported grade 3/4 adverse events (greater than or equal to 10%) suspected of being related to study treatment were neutropenia, lymphopenia, stomatitis, leukopenia, alopecia and anemia.

Study details: abstract #406

An open-label, multicenter Phase I trial evaluated daily RAD001 (2.5 mg, 5 mg and 10 mg) and weekly RAD001 (20 mg, 30 mg, 50 mg and 70 mg) in combination with Navelbine (25 mg/m2 IV over 10-15 min on days 1 and 8 every 21 days) and Herceptin (2 mg/kg IV over 30 min). All patients entering the study had progression on, or shortly after, treatment with Herceptin and all had received prior taxane. The median number of prior chemotherapy regimens was 3 (range: 1-5).

Across treatment arms, there was an overall disease control rate of 62%. Thirty-four heavily pretreated patients were evaluated to date (fifteen patients assigned to 5 mg daily, six to 20 mg weekly, and thirteen to 30 mg weekly). Among the fifteen patients in the 5 mg daily treatment arm, one patient had a complete response, two patients had partial responses, nine patients had stable disease and three patients had progressive disease. Among the six patients in the 20 mg weekly treatment arm, one patient had a partial response, three patients had stable disease and two patients had progressive disease. Among the thirteen patients evaluated in the 30 mg weekly treatment arm, two patients had partial responses, nine pati
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Latest RAD001 Study Results Show Further Increase in Time Without Tumor Growth in Patients With Advanced Kidney Cancer
2. RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors
3. RAD001 Granted Priority Review in the US Based on Potential to Fill Unmet Medical Need in Patients With Advanced Kidney Cancer
4. Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments
5. RAD001 More Than Doubles Time Without Tumor Growth After Failure of Standard Treatment in Patients With Advanced Kidney Cancer
6. Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy
7. New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia
8. Study Shows ACCU-CHEK(R) Blood Glucose Monitoring Systems and Lancing Devices Are Least Painful
9. Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows
10. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
11. Soft Contact Lenses Do Not Lead to Myopic Creep in Children, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ST. PAUL, Minn. , Aug. 3, 2015 /PRNewswire/ ... devices using neuroblocking therapy to treat obesity, metabolic diseases ... C. McDougal has been appointed to the Board ... serve as a Class II Director until the 2018 ... qualified. Ms. McDougal has served in an ...
(Date:8/2/2015)... LONDON , August 3, 2015 ... Dechra Pharmaceuticals PLC ("Dechra" or the "Company") ... share purchase agreement ("SPA") with Mr. Marijan Han ... voting rights) in Genera d.d. ("Genera"), a Croatian listed ... (HRK179.60) per share, which is equivalent to €51.4 million ...
(Date:7/31/2015)... YORK , July 31, 2015  Seeger Weiss LLP ... Administration (FDA) issued a warning letter to C.R. Bard, the ... not taking adequate strides to correct violations the agency found ... of these violations after the FDA cited them during Inspectional ... 2015, in Bard,s Tempe, AZ , location ...
Breaking Medicine Technology:EnteroMedics Announces Appointment of Lori C. McDougal to the Board of Directors 2EnteroMedics Announces Appointment of Lori C. McDougal to the Board of Directors 3Dechra to Acquire 63.3% Shareholding (£19.4m) in Genera d.d. Croatia 2Dechra to Acquire 63.3% Shareholding (£19.4m) in Genera d.d. Croatia 3Dechra to Acquire 63.3% Shareholding (£19.4m) in Genera d.d. Croatia 4Dechra to Acquire 63.3% Shareholding (£19.4m) in Genera d.d. Croatia 5Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 2Seeger Weiss LLP Reports That The FDA Has Issued A Warning Letter To IVC Filter Manufacturer, C.R. Bard 3
... 2011 Thoratec Corporation (NASDAQ: THOR ), ... to save, support and restore failing hearts, said today ... 3rd Annual Circulatory Assist Device Day on Thursday, September ... Relations and Business Development, will provide an update on ...
... 2011 In response to new government data that shows ... Promises Treatment Centers of Los Angeles and Malibu have stepped ... the problem:  prescription narcotic overdoses, particularly among young people. ... death in 2009, killing at least 37,485 people nationwide, according ...
Cached Medicine Technology:Promises Treatment Centers Offers Program Addressing Dramatic Rise in Prescription Pill Addiction by Teens 2
(Date:8/3/2015)... ... August 03, 2015 , ... ... the largest online retailer of nutritional supplements, has officially opened the polls ... 11 awards in the following categories:, ,     Brand of ...
(Date:8/3/2015)... ... August 03, 2015 , ... Social impact organization’s ... 3, 2015 – Since winning a South by Southwest® (SXSW®) Interactive Innovation Award ... organization whose mission is to develop technology for the sake of humanity – ...
(Date:8/3/2015)... ... August 03, 2015 , ... The art of preparing and cooking food comes ... at a young age, Nasreen Zereshki was extremely eager to cook Persian cuisine. Now ... Recipes from My Persian Kitchen with the world. , Since Americans tend to be ...
(Date:8/3/2015)... ... August 03, 2015 , ... AxoGen, Inc. (NASDAQ: AXGN), a leader ... present at the Wedbush Healthcare Conference on Wednesday, August 12, 2015 at 9:45am (ET) ... archived replay of the Company’s presentation may be accessed via the investor relations section ...
(Date:8/3/2015)... , ... August 03, 2015 , ... ... National Forest, to Ahjumawi Lava Springs, California’s northernmost and among its least visited ... untapped ground water aquifers, whose main outflow is at Ahjumawi Lava Springs, part ...
Breaking Medicine News(10 mins):Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 2Health News:BPI Sports is Nominated for 11 Different 2015 Bodybuilding.com Supplement Awards 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 2Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 3Health News:Not Impossible Earns Top Awards for Technologies Benefiting Humanity 4Health News:Persian Cuisine: Colorful and Extremely Healthy 2Health News:AxoGen, Inc. to Present at the Wedbush Healthcare Conference 2Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 2Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 3Health News:Medicine Lake Aquifer could ease California drought says fresh water advocate Sharon Kleyne – but is this necessary? 4
... a greater risk , than they might think SCHAUMBURG, ... 1 million cases of skin cancer ... historically those most at risk for developing skin cancer are ... generally older populations, dermatologists advise that those who do not ...
... A new survey from Noblis Health Innovation, a leading ... of the current economic crisis, nearly a third of hospitals are ... in April 2009, the affiliation study is the first in a ... Insights Panel , a collection of more than 150 leading health ...
... 2009A new review finds hospital volume to be a ... studies, when combined, show a quantifiable and statistically significant ... finds that individual studies often fail to show such ... at best an imperfect proxy for healthcare quality. , ...
... implicated in cardiovascular disease risk for 5000 years. ... investigators from Germany at the University of Erlangen, ... Berlin-Buch and Regensburg, collaborating with researchers from Finland ... relationship between salt intake, bodily processes, and blood ...
... Millennium Research Group releases latest editions of its ... the cardiovascular, endoscopy, orthopedics, aesthetics, and imaging and ... Research Group (MRG), the global authority on medical ... 2009 issues of its Industry Quarterly (IQ) ...
... and not drinking enough water are to blame.ANN ARBOR, ... call from her daughter,s daycare saying that 3-year-old Emma ... cause would be a condition often associated with middle ... over in pain and saying that her back hurt ...
Cached Medicine News:Health News:Consumer Alert: Dermatologists Warn Skin Cancer is an Equal-Opportunity Health Threat 2Health News:Consumer Alert: Dermatologists Warn Skin Cancer is an Equal-Opportunity Health Threat 3Health News:Consumer Alert: Dermatologists Warn Skin Cancer is an Equal-Opportunity Health Threat 4Health News:Consumer Alert: Dermatologists Warn Skin Cancer is an Equal-Opportunity Health Threat 5Health News:Noblis Insights Panel Finds Growing Interest in Hospital Affiliation as a Strategic Response to Challenging Market Conditions 2Health News:Noblis Insights Panel Finds Growing Interest in Hospital Affiliation as a Strategic Response to Challenging Market Conditions 3Health News:Hospital volume inconsistent predictor of quality care 2Health News:New light shed on the enigma of salt intake and hypertension 2Health News:Despite the Economic Downturn, Long-Term Growth Potential in the US Dental Biomaterial Market Remains Robust 2Health News:Kidney Stones in Children on The Rise, U-M Expert Says 2Health News:Kidney Stones in Children on The Rise, U-M Expert Says 3
... Powered (6 size AA required). Fast, Lightweight ... oz, ozt, GN, dwt, mom, dwt, tael), ... Measure functions, Auto Print. Optional hook (321-34532-03) ... may be ordered for AC Operation of ...
... TOPLOAD 620/0.01G, BX620S. Digital stability control, ... measure, piece counting and percent measure ... including date and time data from ... external weights (selectable from 200g to ...
60 month warranty, constructed entirely of aluminum alloy, allows the selection of 11 units of measure....
Thermometer for Round Water Bath...
Medicine Products: