Navigation Links
RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial
Date:12/12/2008

a partial response, six patients had stable disease and one patient had progressive disease. Among the nine patients evaluated in the 30 mg weekly treatment arm, three patients had partial responses, five patients had stable disease and one patient had progressive disease. The critical dose- limiting toxicities occurring in the first cycle of treatment included febrile neutropenia, oral mucositis and confusion occurring in the 5 mg daily, 10 mg daily and 30 mg weekly treatment groups, respectively. The most commonly reported grade 3/4 adverse events (greater than or equal to 10%) suspected of being related to study treatment were neutropenia, lymphopenia, stomatitis, leukopenia, alopecia and anemia.

Study details: abstract #406

An open-label, multicenter Phase I trial evaluated daily RAD001 (2.5 mg, 5 mg and 10 mg) and weekly RAD001 (20 mg, 30 mg, 50 mg and 70 mg) in combination with Navelbine (25 mg/m2 IV over 10-15 min on days 1 and 8 every 21 days) and Herceptin (2 mg/kg IV over 30 min). All patients entering the study had progression on, or shortly after, treatment with Herceptin and all had received prior taxane. The median number of prior chemotherapy regimens was 3 (range: 1-5).

Across treatment arms, there was an overall disease control rate of 62%. Thirty-four heavily pretreated patients were evaluated to date (fifteen patients assigned to 5 mg daily, six to 20 mg weekly, and thirteen to 30 mg weekly). Among the fifteen patients in the 5 mg daily treatment arm, one patient had a complete response, two patients had partial responses, nine patients had stable disease and three patients had progressive disease. Among the six patients in the 20 mg weekly treatment arm, one patient had a partial response, three patients had stable disease and two patients had progressive disease. Among the thirteen patients evaluated in the 30 mg weekly treatment arm, two patients had partial responses, nine pati
'/>"/>

SOURCE Novartis Pharmaceuticals Corporation
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Latest RAD001 Study Results Show Further Increase in Time Without Tumor Growth in Patients With Advanced Kidney Cancer
2. RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors
3. RAD001 Granted Priority Review in the US Based on Potential to Fill Unmet Medical Need in Patients With Advanced Kidney Cancer
4. Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments
5. RAD001 More Than Doubles Time Without Tumor Growth After Failure of Standard Treatment in Patients With Advanced Kidney Cancer
6. Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy
7. New Study Shows PCR and FCR Have Significant Activity in B-cell Chronic Lymphocytic Leukemia
8. Study Shows ACCU-CHEK(R) Blood Glucose Monitoring Systems and Lancing Devices Are Least Painful
9. Dramatic JUPITER Findings Fail to Sway Prescribing Behavior, Poll Shows
10. Third Pivotal Phase 3 Study for NicOx Naproxcinod Shows Positive Efficacy, Safety and Blood Pressure Results
11. Soft Contact Lenses Do Not Lead to Myopic Creep in Children, Study Shows
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... --  Evana Automation Specialists , a leading Systems Integrator ... recently received a contract to provide a robotic assembly ... solution will help error-proof the process of assembling catheter ... labor. A catheter adapter, connector and ... The robot will pick the adapter, connector and O-ring ...
(Date:9/16/2014)... , Sept. 16, 2014 On September 25 ... exhibition focusing on medical design and manufacturing - MEDTEC ... Shanghai World Expo Exhibition & Convention Center, bringing together ... and regions to showcase their latest medical-grade raw materials, ... only one week remaining for free visitor pre-registration to ...
(Date:9/16/2014)... The Lupus Foundation of America and Eli ... released results from UNVEIL: understanding the impact of lupus, ... journey and the challenges not only for those living ... study, which involved over 1,000 people with lupus and ... all aspects of life including family, work, finances, treatment ...
Breaking Medicine Technology:Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 2Evana Automation to Supply Robotic Assembly Cell to Leading Medical Device Manufacturer 3MEDTEC China 2014: Seven Highlights Not to Miss! 2MEDTEC China 2014: Seven Highlights Not to Miss! 3MEDTEC China 2014: Seven Highlights Not to Miss! 4"UNVEIL" Survey Reveals a Life Interrupted by Lupus 2"UNVEIL" Survey Reveals a Life Interrupted by Lupus 3"UNVEIL" Survey Reveals a Life Interrupted by Lupus 4"UNVEIL" Survey Reveals a Life Interrupted by Lupus 5
... 2, 2011 Floridians turned in nearly 5,500 pounds ... pharmacies and law enforcement offices throughout the state during ... more than doubling the amount dropped off at 38 ... Back Day, the National Association of Drug Diversion ...
... 2, 2011 What do Robert DeNiro, Hugo Chavez, Rudy ... Mandela, Colin Powell, Frank Zappa, Telly Savalas, Bill Bixby and ... answer is prostate cancer, then you would be correct. ... all diagnosed and successfully treated.  Chavez, the President of Venezuela, ...
Cached Medicine Technology:NADDI and the C.A.R.E.S. Alliance Co-Sponsor Successful Drug Take Back Day 2
(Date:9/16/2014)... magnesium sulfate is routinely given to pregnant women at ... won,t provide any long-term benefits for infants. ... pregnant women, researchers in Australia found it had no ... those children when they were assessed at between 6 ... negate the fact that the drug is helpful in ...
(Date:9/16/2014)... therapy as part of breast conservation is the ... positive (HR+) invasive breast cancer. A new study ... shows that combination may not be necessary for ... The results, which Fox Chase researchers presented at ... Meeting on Sunday, September 14, suggest that low-risk ...
(Date:9/16/2014)... Programs and policies that promote health and disease ... in savings for the US health system, according to ... spur these types of improvements, the National Quality Forum ... across the country to field test the NQF Action ... designed to assist groups working together to improve health ...
(Date:9/16/2014)... Silver Spring, Md. (PRWEB) September 16, 2014 ... University of Colorado Anschutz Medical Campus and Children’s ... 2014. PHA is the country’s leading pulmonary hypertension association ... hypertension (PH) – a disease of the lungs that affects ... heart failure. Without treatment, mean survivability is only 2.8 years. ...
(Date:9/16/2014)... By Tara Haelle ... -- A new blood test is the first objective scientific ... claims. The test measures the levels of nine genetic ... test could also determine who will respond to cognitive behavioral ... depression, and could show whether the therapy worked, Northwestern University ...
Breaking Medicine News(10 mins):Health News:Researchers Don't See Long-Term Benefits From Drug for Preemies 2Health News:Benefit of endocrine therapy in elderly women with low risk hormone receptor positive breast cancer? 2Health News:Benefit of endocrine therapy in elderly women with low risk hormone receptor positive breast cancer? 3Health News:NQF Seeks Field Testing Groups for Population Health Guide 2Health News:NQF Seeks Field Testing Groups for Population Health Guide 3Health News:Help Fight Pulmonary Hypertension at the Colorado PH in the Park 2014 2Health News:Blood Test Spots Adult Depression: Study 2Health News:Blood Test Spots Adult Depression: Study 3
... major medical advances improved survival , TUESDAY, ... has reduced the death rate for patients hospitalized for ... deal with these daily emergencies, a nationwide study finds. ... for Medicare patients treated for heart attacks decreased, from ...
... ACMIC reduces costs ... ... -- Corticon Technologies , the leading provider of Business Rules Management Systems (BRMS) ... gone live with an upgraded claims processing system built on Corticon BRMS. , ,For ...
... , Price of Diabetes ... , , BETHESDA, Md., Aug. ... people with diabetes has been misconstrued during recent health care ... the nation,s leading professional organization of doctors of podiatric medicine ...
... OKLAHOMA CITY, Aug. 18 Almost everyone who lives a long life ... at some point. As more Americans live into their 70s and ... tips that may delay onset, and how to decide when it is time ... August is Cataract Awareness Month, and the Oklahoma Academy of Ophthalmology (OAO) encourages ...
... maybe depressed, new U.S. survey of Internet players finds ... video gamer is not the stereotypical adolescent locked to ... a new U.S. survey, are 35-year-old adults, many of ... , The surprising findings also show that the health ...
... ... application called Med Records to Go(tm) , that stores electronic medical ... hospital or medical clinic admissions. Introduced by the Vital Record Corporation ... record and store personal health information and external documents for emergency viewing ...
Cached Medicine News:Health News:Hospitals Reduce Heart Attack Deaths 2Health News:Hospitals Reduce Heart Attack Deaths 3Health News:American Community Mutual Insurance Company (ACMIC) Selects Corticon 2Health News:American Community Mutual Insurance Company (ACMIC) Selects Corticon 3Health News:American Community Mutual Insurance Company (ACMIC) Selects Corticon 4Health News:American Podiatric Medical Association Corrects President's Misstatement on Foot Amputation Costs 2Health News:What Oklahomans Should Know About Cataract Surgery 2Health News:What Oklahomans Should Know About Cataract Surgery 3Health News:Video Gamers Older Than You Think 2Health News:Video Gamers Older Than You Think 3Health News:Video Gamers Older Than You Think 4Health News:"Med Records to Go" Stores Document and Image Files of Medical Facilities for Emergency Viewing 2Health News:"Med Records to Go" Stores Document and Image Files of Medical Facilities for Emergency Viewing 3
... cervical spine manipulation. Prevent dental and soft ... effective alternative to X-ray. Light-guided intubation is ... tissues in the neck. This technique takes ... trachea relative to the esophagus. A well-defined, ...
Bivona® stylets are manufactured of malleable stainless steel wire. The length can be adjusted by sliding the attached silicone stopper. The Blue Line® tracheal tube introducer (bougie) is de...
Bivona® stylets are manufactured of malleable stainless steel wire. The length can be adjusted by sliding the attached silicone stopper. The Blue Line® tracheal tube introducer (bougie) is de...
All endotracheal accessories are designed to ensure your technique. The Blue Line® intubation stylets feature a satin-smooth coating and are available in three sizes....
Medicine Products: