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RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors
Date:9/13/2008

- 82% of patients with pancreatic neuroendocrine tumors (NET) experienced clinical benefit when treated with daily RAD001 and monthly Sandostatin LAR

Depot - 77% of patients with pancreatic NET experienced clinical benefit when

treated with daily RAD001 - Data show RAD001, an oral mTOR inhibitor, has potential to become new treatment for patients with pancreatic NET who currently have limited

options - Phase III trials underway to confirm impact of combination RAD001 and Sandostatin LAR Depot therapy on survival in pancreatic NET and carcinoid

patients

EAST HANOVER, N.J., Sept. 13 /PRNewswire-FirstCall/ -- New data show that combination treatment with RAD001 (everolimus) and Sandostatin LAR(R) Depot (octreotide acetate for injectable suspension) and RAD001 given alone control tumor growth in patients with pancreatic neuroendocrine tumors (NET), a rare and difficult-to-treat form of cancer.

These results, from the RADIANT-1 (RAD001 In Advanced Neuroendocrine Tumors) study, were presented today at the 33rd European Society for Medical Oncology (ESMO) Congress in Stockholm, Sweden.

In the trial, patients with pancreatic NET who became resistant to chemotherapy were given either daily RAD001 combined with monthly Sandostatin LAR Depot or daily RAD001 alone. The results showed that 82% of patients receiving combination therapy and 77% receiving monotherapy had tumors that either decreased in size or remained stable.

"Pancreatic neuroendocrine tumors cause debilitating symptoms related to hormone production and typically claim the lives of patients within five years despite treatment with chemotherapy, which is the current standard of care," said James Yao, MD, Associate Professor of Medicine at The University of Texas M. D. Anderson Cancer Center. "Results from this trial show the promise of RAD0
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SOURCE Novartis Pharmaceuticals Corporation
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