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R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent
Date:7/23/2009

n blood pressure medications such as ACE inhibitors or diuretics.

"For this patient population, patients who failed biologic therapies, their bones and joints appear to respond to R788, but the objective and subjective components of the ACR and DAS28 scores are incongruent, mainly because the reported subjective placebo response rates were higher than expected," said Elliott Grossbard, M.D., chief medical officer for Rigel. "Nonetheless, R788 is well tolerated and its side effects appear generally manageable, and we look forward to planning our Phase 3 program for R788 with a corporate partner," he added.

    Safety Results Tables
                                              Placebo         100 mg bid
                                              -------         ----------
    N                                            73              146
    ---                                         ---              ---
    Dose Reductions                          N         %        N         %
    ---------------                        ---       ---      ---       ---
    # Had a Dose Reduction                   2        3%       21       14%
    ----------------------                 ---       ---      ---       ---
    Neutropenia (ANC less than 1500)         0        0%        3        2%
    --------------------------------       ---       ---      ---       ---
    Diarrhea, nausea, vomiting,
     dizziness                               1        1%        7        5%
    ---------------------------            ---       ---      ---       ---
    Increase in Blood Pressure (BP)          1        1%        7        5%
    -------------------------------        ---       ---      ---       ---
    ALT or Alkphos Elevation                 0        0%        4        3%
    ------------------------               ---       ---      ---       ---



    TASKi3 Treatment Emergent Adverse Events

      
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SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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