Navigation Links
R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent
Date:7/23/2009

p=0.058 ---------- ----- ----- ------- Erosion Score +0.94 +0.78 p=0.62 ------------- ----- ----- ------ * RAMRIS is a rheumatoid arthritis scoring system utilizing magnetic resonance imaging to evaluate abnormalities (synovitis, bone edema and bone erosion) in the hands and wrists. The system was developed by OMERACT, (Outcome Measurements in Rheumatology) in 2002, and has become a global standard measurement of inflammation and destruction in those joints. For these scores a lower value indicates a better clinical condition. ** Synovitis: inflammation of the synovial membrane lining joints Osteitis: inflammation of the bone

Safety Results

Similar to TASKi2, the most common clinically meaningful drug-related adverse events noted in TASKi3 were diarrhea and hypertension. Dose reduction options were pre-specified in the trial protocol and, in cases where doses were reduced, patients generally completed the clinical trial with minimal safety issues. The most common adverse events in the trial overall were related to infections, though these were generally evenly distributed among the placebo and active dose group.

The mean increase in blood pressure from baseline at 3 months, using a last observation carry forward methodology, was 3.2-3.6 mmHg for the 100 mg bid dose group. In TASKi3, approximately 17% of patients in the 100 mg bid dose group had blood pressure medication adjusted or in some cases initiated during the course of the clinical trial, compared to 8% of the placebo patients. For those patients who had their dose of blood pressure medications adjusted or initiated, their blood pressure was successfully reduced and their blood pressure was generally well controlled throughout the trial. The blood pressure medications were standard doses of commo
'/>"/>

SOURCE Rigel Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7 8

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
4. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
5. Romark Initiates Clinical Trial of Alinia(R) for Chronic Hepatitis C in the United States
6. The Multiple Myeloma Research Consortium (MMRC) and Proteolix Initiate Phase 2 Clinical Trial Investigating Carfilzomib for the Treatment of Multiple Myeloma
7. Millennium Initiates Clinical Trial to EVOLVE the Treatment of Patients with Newly Diagnosed Multiple Myeloma
8. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
9. Clinical Trial Effectiveness: How Pharmas & Biotechs Save Cost with Savvy Investigator Management
10. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
11. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 31, 2015 Magnaquest, a ... data and cloud computing operators has signed a ... giant for Internet of Things (IoT) related initiative. ... on subscription model.      (Logo: ... striving for business innovations to make healthcare services ...
(Date:7/30/2015)... Calif. , July 30, 2015 IRIDEX ... will release its second quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
(Date:7/30/2015)... bring you a special edition of #MedicareMonday on Medicare,s 50 th anniversary. As ... resources and continue highlighting the success of the prescription drug benefit, commonly referred to ... our latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3
(Date:7/31/2015)... ... July 31, 2015 , ... ZH Healthcare announces a new cloud based ... HITaaS? Health IT as a Service (HITaaS) is a Healthcare dedicated cloud based service ... , HITaaS manages all aspects of infrastructure, security, runtime, middleware, OS, ...
(Date:7/31/2015)... ... July 31, 2015 , ... Physical therapy for knee osteoarthritis ... quality of life. It keeps the patient from doing what they want or need to ... a hard time using the stairs. The patient's exercise regime may be limited by the ...
(Date:7/31/2015)... , ... July 31, 2015 , ... New Energy Works ... Stage Amphitheater in McMinnville, Oregon August 15th, 2015 from 9am – 12pm. Timber ... and important day for the entire community as the culmination of months of effort, ...
(Date:7/31/2015)... ... , ... The Radiology Business Management Association’s 2015 Fall Educational ... Health Care: A View From Capitol Hill” on Sunday, Sept. 27, 2015, in Austin, ... Burgess has a special understanding of the real world impact of health care policy ...
(Date:7/31/2015)... ... July 31, 2015 , ... “ Crack’em ” was featured on NewsWatch as ... available to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted ... while cooking. , Cooking can be a very messy experience, especially when cracking eggs. ...
Breaking Medicine News(10 mins):Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 2Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 3Health News:ZH Healthcare Unveils Health IT as a Service (HITaaS) at OSEHRA 2015 4Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 2Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 3Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 2Health News:Timber Frame Raising: Granary District Stage Amphitheater Timber Frame Hand-Raising by New Energy Works Timberframers 3Health News:Congressional Health Caucus Founder Rep. Michael Burgess, MD, to Speak at RBMA Fall Educational Conference 2Health News:Congressional Health Caucus Founder Rep. Michael Burgess, MD, to Speak at RBMA Fall Educational Conference 3Health News:Make Less Mess while Cooking with Crack’em 2
... as special events, even though result is technically a ... near-win in gambling stimulates a large portion of the ... motivation to gamble, according to British researchers. , They ... attracts so many people and why some develop a ...
... The Consortium for Enterprise Systems Management, a recently ... organizations intended to build information technology (IT) opportunities, ... as the interim executive director.Previously director of staff ... of South Carolina, Emard was instrumental in building ...
... Relationship , Between Edwards and Primary Sponsor with HumorCOLUMBUS, ... first year as primary sponsor of Carl Edwards and ... with the launch of its latest television spots, "Monster ... during the national broadcast of the Feb. 15 Daytona ...
... - Conference Call to Discuss Results to Be Held at ... Incorporated,s (Nasdaq: VPHM ) fourth quarter and year ... on Tuesday, February 24, 2009 before the open of the ... live audio webcast at 9:00 a.m. Eastern Time on the ...
... of newly transplanted organs and cells, patients must ... Such potentially life-saving treatments can, paradoxically, leave those ... Now researchers at the University of North Carolina ... UNC Lineberger Comprehensive Cancer Center have discovered what ...
... , Montreal, February 11th, 2009 - The development ... tumours receive through the blood. The team of Dr. Janusz ... Centre (MUHC) at the Montreal Children,s Hospital, including Dr. Khalid ... that tumours use to stimulate the growth of the blood ...
Cached Medicine News:Health News:'Near-Wins' Boost Desire to Keep Gambling 2Health News:S.C.-Based Technology Consortium Names Interim Executive Director and Board 2Health News:S.C.-Based Technology Consortium Names Interim Executive Director and Board 3Health News:New Ads Provide Glimpse Into Unique Friendship Between Aflac Duck and Carl Edwards 2Health News:New Ads Provide Glimpse Into Unique Friendship Between Aflac Duck and Carl Edwards 3Health News:New Ads Provide Glimpse Into Unique Friendship Between Aflac Duck and Carl Edwards 4Health News:ViroPharma to Release 2008 Fourth Quarter and Full Year Financial Results on February 24, 2009 2Health News:UNC study hints at new approaches to prevent transplant rejection 2Health News:UNC study hints at new approaches to prevent transplant rejection 3Health News:Innovative method to starve tumors 2
Accurate implant size. Polyoxymethylene (POM)....
Straight iris forceps. Insulated....
Semkin forceps with stops. Insulated....
Cushing bayonet forceps. Insulated....
Medicine Products: