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R&D Trends: Depression - Clinical attrition driven by mature market conditions
Date:3/22/2012

ld standard for depression: key clinical trial results for Lexapro

Table: Target product profile in major depressive disorder, 2012

Table: Comparison between the HAM-D and MADRS rating scales for depression

Table: Typical Phase III clinical trial design in major depressive disorder

Table: Key facts: Lexapro (escitalopram; Forest/Lundbeck) versus Cymbalta (duloxetine; Eli Lilly) comparator trial in major depressive disorder

Table: Key facts: Symbyax (fluoxetine and olanzapine; Eli Lilly) pivotal Phase III clinical trial

Table: Key facts: Abilify (aripiprazole; Bristol-Myers Squibb/Otsuka) pivotal Phase III clinical trial

Table: Most promising innovative therapeutic approaches in depression, January 2012

 

FIGURES

Figure: Depression clinical pipeline, by developmental stage, January 2012

Figure: Depression clinical pipeline, by mode of action, January 2012

Figure: Products in clinical development for depression, 2007, 2011, and 2012

Figure: Modes of action in the depression pipeline, 2007, 2011, and 2012

Figure: Depression pipeline, by developmental stage and company type, January 2012

Figure: Big Pharma's involvement in the depression pipeline, January 2012

Figure: Discontinued drugs formerly in development for depression, by developmental stage, 2010–12

Figure: Modes of action of discontinued pipeline drugs and active pipeline drugs in depression, 2010–12

Figure: Head-to-head clinical trial of Lexapro (escitalopram; Forest/Lundbeck) versus Celexa (citalopram; Forest/Lundbeck)

Figure: Potential timeline for future depression therapies

Figure: Proportion of patients that display treatment-resistant depression (%) in the seven major markets, 2010

Figure: BRITE-MD study of the Antidepressant Treatment Response Index as a functional biomarker for depression

 

 

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